Muc1
MUC1，即黏蛋白1，别名MAM6、EMA等。它是一种高度糖基化的I型跨膜蛋白，由MUC1基因编码，该基因位于染色体1q22上，通过选择性剪接可产生多种亚型。MUC1蛋白主要包括细胞外区域、跨膜区和细胞质区，其中细胞外区域包含大量可发生O-糖基化的丝氨酸和苏氨酸残基，这些糖基化对于MUC1的生物学功能至关重要 。MUC1在生物学上的意义非常广泛，它在正常上皮细胞中作为保护性屏障，防止外界环境及微生物的侵害。然而，在肿瘤细胞中，MUC1的表达量通常会增高，并且其结构和糖基化水平也会发生改变。这些改变可能导致新的抗原表位的暴露，为肿瘤的诊断和治疗提供了潜在的靶点。MUC1还参与了多种信号通路的调控，包括MAPK、PI3K/Akt和Wnt路径，这些信号通路在肿瘤细胞代谢、细胞凋亡、上皮间质转化和远处转移中发挥重要作用 。MUC1的异常表达与肿瘤的侵袭性和转移能力密切相关，使其成为肿瘤治疗和诊断中的一个重要靶点。
热销产品
Recombinant Human Mucin-1 (MUC1) (CSB-EP015215HU)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
MUC1 Antibody (CSB-PA11319A0Rb)
验证数据
Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA11319A0Rb at dilution of 1:100
Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA11319A0Rb at dilution of 1:100
Immunofluorescent analysis of MCF-7 cells using CSB-PA11319A0Rb at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
Muc1 Antibodies
Muc1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA11319A0Rb | MUC1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA11319C0Rb | MUC1 Antibody, FITC conjugated | Human | |
| CSB-PA015215GA01HU | MUC1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA11319B0Rb | MUC1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA11319D0Rb | MUC1 Antibody, Biotin conjugated | Human | ELISA |
| CSB-PA150023 | Phospho-MUC1 (Tyr1229) Antibody | Human | ELISA,WB,IHC,IF |
| CSB-PA003334 | MUC1 Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA006277 | MUC1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA010263 | Phospho-MUC1 (Y1229) Antibody | Human | WB, IHC, IF, ELISA |
| CSB-PA010272 | Phospho-MUC1 (Y1243) Antibody | Human,Mouse | IHC, ELISA |
| CSB-PA010274 | Phospho-MUC1 (S1227) Antibody | Human | IHC, ELISA |
| CSB-PA010276 | MUC1 Antibody | Human | IHC, ELISA |
| CSB-PA010277 | MUC1 Antibody | Human | IHC, IF, ELISA |
| CSB-PA010279 | MUC1 Antibody | Human,Mouse | IHC, IF, ELISA |
| CSB-PA141385 | MUC1 Antibody | Human | ELISA,IHC |
| CSB-PA114224 | MUC1 Antibody | Human | ELISA,WB,IHC |
| CSB-PA692815 | MUC1 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA583379 | MUC1 Antibody | Human,Mouse | ELISA,IHC |
Muc1 Proteins
Muc1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP312543MO CSB-EP312543MO CSB-BP312543MO CSB-MP312543MO CSB-EP312543MO-B |
Recombinant Mouse Mucin-1 (Muc1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Muc1 Proteins for Hylobates lar (Common gibbon)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP645848HXW CSB-EP645848HXW CSB-BP645848HXW CSB-MP645848HXW CSB-EP645848HXW-B |
Recombinant Hylobates lar Mucin-1 (MUC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Muc1 Proteins for Mesocricetus auratus (Golden hamster)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP726652MRG CSB-EP726652MRG CSB-BP726652MRG CSB-MP726652MRG CSB-EP726652MRG-B |
Recombinant Mesocricetus auratus Mucin-1 (MUC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Muc1 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP848794BO CSB-EP848794BO CSB-BP848794BO CSB-MP848794BO CSB-EP848794BO-B |
Recombinant Bovine Mucin-1 (MUC1), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Muc1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-MP015215HU3-B | Recombinant Human Mucin-1(MUC1),partial,Biotinylated | Mammalian cell |
Muc1 ELISA Kit
Muc1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-E04772h | Human mammary carcinoma marker CA15-3 (CA15-3) ELISA kit | serum | 3.8 U/mL |
