Mc4r
MC4R，即黑皮质素4受体”，别名Melanocortin 4 Receptor、Melanocortin Receptor 4、MC4-R、Mutant Melanocortin-4 Receptor等。它是一种膜结合受体，属于黑皮质素受体家族成员，由人体细胞自身的基因编码。MC4R主要在下丘脑中表达，参与控制食物摄取、能量消耗和体重维持等 。MC4R的作用机制主要是通过与黑皮质素激素如α-黑素细胞刺激激素（α-MSH）等内源性配体结合，通过G蛋白偶联的方式激活腺苷酸环化酶（cAMP）信号通路，从而发出饱腹感信号，减少食物摄入。MC4R的激活还涉及多种代谢信号的处理，如瘦素、饥饿素和神经肽Y (NPY)等，调节人体能量代谢和进食行为 。MC4R在生物学上的意义非常重大，它不仅参与了能量平衡和体重调节，还与多种代谢性疾病的发生发展密切相关。例如，MC4R的功能异常或突变与肥胖症有关，MC4R激动剂如setmelanotide已被批准用于治疗某些类型的肥胖症。此外，MC4R的激活还可能影响情绪、奖赏和认知功能，对心理健康和行为也有潜在影响 。
热销产品
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA254627(MC4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CSB-PA254627(MC4R Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
Mc4r Antibodies
Mc4r for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA010101 | MC4R Antibody | Human,Mouse,Rat | WB, IHC, ELISA |
| CSB-PA934831 | MC4R Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA254627 | MC4R Antibody | Human,Mouse | ELISA,IHC |
| CSB-PA013561LA01HU | MC4R Antibody | Human | ELISA, IHC |
| CSB-PA013561LB01HU | MC4R Antibody, HRP conjugated | Human | ELISA |
| CSB-PA013561LC01HU | MC4R Antibody, FITC conjugated | Human | |
| CSB-PA013561LD01HU | MC4R Antibody, Biotin conjugated | Human | ELISA |
Mc4r Proteins
Mc4r Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013561RA1 CSB-EP013561RA1 CSB-BP013561RA1 CSB-MP013561RA1 CSB-EP013561RA1-B |
Recombinant Rat Melanocortin receptor 4 (Mc4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561RA | Recombinant Rat Melanocortin receptor 4 (Mc4r) | in vitro E.coli expression system |
Mc4r Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013561HU1 CSB-EP013561HU1 CSB-BP013561HU1 CSB-MP013561HU1 CSB-EP013561HU1-B |
Recombinant Human Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561HU | Recombinant Human Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
Mc4r Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013561MO1 CSB-EP013561MO1 CSB-BP013561MO1 CSB-MP013561MO1 CSB-EP013561MO1-B |
Recombinant Mouse Melanocortin receptor 4 (Mc4r), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561MO | Recombinant Mouse Melanocortin receptor 4 (Mc4r) | in vitro E.coli expression system |
Mc4r Proteins for Sus scrofa (Pig)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP013561PI1 CSB-EP013561PI1 CSB-BP013561PI1 CSB-MP013561PI1 CSB-EP013561PI1-B |
Recombinant Pig Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF013561PI | Recombinant Pig Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
Mc4r Proteins for Vulpes vulpes (Red fox)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP604515VFW1 CSB-EP604515VFW1 CSB-BP604515VFW1 CSB-MP604515VFW1 CSB-EP604515VFW1-B |
Recombinant Vulpes vulpes Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF604515VFW | Recombinant Vulpes vulpes Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
Mc4r Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP808487MOV1 CSB-EP808487MOV1 CSB-BP808487MOV1 CSB-MP808487MOV1 CSB-EP808487MOV1-B |
Recombinant Macaca fascicularis Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF808487MOV | Recombinant Macaca fascicularis Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
Mc4r Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP872388BO1 CSB-EP872388BO1 CSB-BP872388BO1 CSB-MP872388BO1 CSB-EP872388BO1-B |
Recombinant Bovine Melanocortin receptor 4 (MC4R), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF872388BO | Recombinant Bovine Melanocortin receptor 4 (MC4R) | in vitro E.coli expression system |
