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MIF

巨噬细胞迁移抑制因子(Macrophage migration inhibitory factor,MIF)是一种具有广泛功能的细胞因子,该因子在炎症及免疫方面有不可替代的作用。人体中,细菌抗原刺激白细胞释放MIF到血流中。循环的MIF结合其它免疫细胞上的CD74进而引发急性免疫反应,因此MIF是一种炎性细胞因子。此外,糖皮质激素(Glucocorticoid,GC)也可刺激白细胞释放MIF。MIF通过抑制糖皮质激素的消炎效果来调节巨噬细胞在宿主防御中的功能。而MIF是截至目前被认为唯一能负向调节GC抗炎作用的细胞因子。除了在炎症的调控中起作用,MIF编码的主要组织相容性复合体(MHC)Ⅰ及Ⅱ类分子,在抗肿瘤细胞毒作用中起着限制性识别和介导杀伤的重要作用,亦参与了肿瘤发生发展过程。

Recombinant Human MIF 活性蛋白实验验证数据

High Purity Validated by SDS-PAGE

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Excellent Bioactivity Validated by Functional ELISA

Measured by its binding ability in a functional ELISA. Immobilized MIF at 2 μg/ml can bind Anti- MIF Rabbit Monoclonal Antibody(CSB-RA146975A0HU), the EC50 is 49.61-69.45 ng/ml.


MIF Antibodies

MIF for Homo sapiens (Human)

MIF for Mus musculus (Mouse)

MIF Proteins

MIF Proteins for Sus scrofa (Pig)

MIF Proteins for Bos taurus (Bovine)

MIF Proteins for Homo sapiens (Human)

MIF Proteins for Mus musculus (Mouse)

MIF Proteins for Rattus norvegicus (Rat)

MIF Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

MIF Proteins for Meriones unguiculatus (Mongolian jird) (Mongolian gerbil)

MIF Proteins for Wuchereria bancrofti

MIF Proteins for Ovis aries (Sheep)

MIF Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

MIF Proteins for Macaca mulatta (Rhesus macaque)

MIF Proteins for Xenopus laevis (African clawed frog)

MIF ELISA Kit

MIF ELISA Kit for Homo sapiens (Human)

MIF ELISA Kit for Mus musculus (Mouse)

MIF ELISA Kit for Rattus norvegicus (Rat)