Folr1
FOLR1（叶酸受体1）是一种成人叶酸受体，也称为叶酸结合蛋白（FBP），由FOLR1基因编码。这种膜结合糖蛋白对叶酸和几种还原叶酸衍生物具有高亲和力，主要功能是介导5-甲基四氢叶酸的细胞内运输，对细胞生长和增殖至关重要。FOLR1的结构包括跨膜结构域，并存在膜结合和可溶性两种形式。 除了在叶酸转运中的基本作用外，FOLR1还参与了多种信号通路，包括JAK-STAT3、ERK1/2信号通路，并可能作为转录因子参与基因表达调控。FOLR1在Wnt和ERK信号通路中发挥作用，通过增加活性β-catenin、磷酸化ERK以及Wnt和ERK调控基因的表达。此外，FOLR1还可能参与Wnt和TGFβ信号通路。 FOLR1的异常表达与多种癌症的发生、发展密切相关，其在肿瘤细胞中的高表达通常与癌症进展加快和患者预后不良有关。因此，FOLR1不仅是癌症治疗研究中的潜在靶点，而且在叶酸受体靶向治疗领域具有重要的应用前景。
热销产品
Recombinant Human Folate receptor alpha(FOLR1),partial (Active) (CSB-MP008784HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized human FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC50 is 6.893-7.883 ng/mL.
The purity of FOLR1 was greater than 95% as determined by SEC-HPLC
Recombinant Macaca fascicularis Folate receptor alpha(FOLR1),partial (Active) (CSB-MP5002MOV)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity
Measured by its binding ability in a functional ELISA. Immobilized Cynomolgus FOLR1 at 2 μg/ml can bind Anti-FOLR1 recombinant antibody(CSB-RA008784MA1HU). The EC50 is 2.900-3.544 ng/mL.
Folr1 Antibodies
Folr1 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA008378 | FOLR1 Antibody | Human,Mouse,Rat | WB, ELISA |
| CSB-PA008784LA01HU | FOLR1 Antibody | Human | ELISA, IHC, IF |
| CSB-PA008784LB01HU | FOLR1 Antibody, HRP conjugated | Human | ELISA |
| CSB-PA008784LC01HU | FOLR1 Antibody, FITC conjugated | Human | |
| CSB-PA008784LD01HU | FOLR1 Antibody, Biotin conjugated | Human | ELISA |
Folr1 Proteins
Folr1 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008784HU CSB-EP008784HU CSB-BP008784HU CSB-MP008784HU CSB-EP008784HU-B |
Recombinant Human Folate receptor alpha (FOLR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Folr1 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008784MO CSB-EP008784MO CSB-BP008784MO CSB-MP008784MO CSB-EP008784MO-B |
Recombinant Mouse Folate receptor alpha (Folr1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Folr1 Proteins for Bos taurus (Bovine)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP008784BO CSB-EP008784BO CSB-BP008784BO CSB-MP008784BO CSB-EP008784BO-B |
Recombinant Bovine Folate receptor alpha (FOLR1) | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
Folr1 ELISA Kit
Folr1 ELISA Kit for Homo sapiens (Human)
| 产品货号 | 产品名称 | 样本类型 | 灵敏度 |
|---|---|---|---|
| CSB-EL008784HU | Human Folate receptor alpha(FOLR1) ELISA kit | serum, plasma, tissue homogenates | 0.09 ng/ml |
