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  4. Recombinant Mouse Folate receptor alpha (Folr1)

Recombinant Mouse Folate receptor alpha (Folr1)

  • 货号：
    CSB-YP008784MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008784MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008784MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008784MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008784MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Folr1; Fbp1; Folbp1Folate receptor alpha; FR-alpha; Folate receptor 1; Folate-binding protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    25-232
  • 氨基酸序列
    TRARTE LLNVCMDAKH HKEKPGPEDN LHDQCSPWKT NSCCSTNTSQ EAHKDISYLY RFNWNHCGTM TSECKRHFIQ DTCLYECSPN LGPWIQQVDQ SWRKERILDV PLCKEDCQQW WEDCQSSFTC KSNWHKGWNW SSGHNECPVG ASCHPFTFYF PTSAALCEEI WSHSYKLSNY SRGSGRCIQM WFDPAQGNPN EEVARFYAEA MS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. Required for renal folate reabsorption.
  • 基因功能参考文献：
    1. Several experimental studies in mice and human epidemiological and genetics studies have suggested that FOLR1 abnormalities are involved in a portion of human neural tube defects (NTD), although the solo defect of FOLR1 did not cause NTD. (Review) PMID: 28244241
    2. Midbrain dopamine neural progenitors and nascent dopamine neurons specifically express Folr1. PMID: 27580818
    3. The above showed that human FRalpha based DNA vaccination with CpG oligodeoxynucleotides as an adjuvant was effective in growth inhibition of a FRalpha expressing tumor in mice and deserves further evaluation as a possible immunotherapy PMID: 28498413
    4. Folate receptor alpha upregulates Oct4, Sox2 and Klf4 and downregulates miR-138 and miR-let-7 in cranial neural crest cells. PMID: 27300003
    5. not detected in oocytes PMID: 27122634
    6. Folate receptor expression on murine and human adipose tissue macrophages PMID: 26149693
    7. Quantitative RT-PCR showed that Slc19a1 mRNA was expressed in mouse cumulus-oocyte complexes (COCs) and oocytes, whereas Folr1 showed expression only in preimplantation embryos, increasing from the 2-cell stage onward. PMID: 23904512
    8. under conditions of reduced folate (Folr-/-) signalling, pathways crucial for proper development of the neural tube are significantly altered. PMID: 21649587
    9. Nesting of T helper cell epitopes results in recruitment of latent pools of naive high-affinity/avidity folate receptor (FR)alpha-specific T cells, which have the ability to home to tumors expressing FRalpha and to reduce tumor burden. PMID: 21613617
    10. Fbp1 has a role in anterior neural tube closure PMID: 12508232
    11. Neural and orofacial defects are associated with Folbp1 knockout mice PMID: 12854656
    12. Expression of genes in the anterior neural tube of gestational day 9 Folbp1-/- embryos PMID: 15176467
    13. Has a prominent role in mediating susceptibility to heart defects. PMID: 15259034
    14. folbp1 is essential for normal renal tubular folate reabsorption, preventing excessive urinary folate loss PMID: 15703271
    15. Folbp1 regulates apoptosis and cell proliferation that underlies the aberrant neural tube and craniofacial defects PMID: 15800851
    16. Abnormal heart looping was observed during early development of Folr1(-/-) embryos partially rescued by maternal folinic acid supplementation. PMID: 17286298
    17. folate receptor type beta is induced in a bone marrow engraftment model of acute myelogenous leukemia PMID: 17554378
    18. Folr1 gene ablation and abnormal folate homeostasis altered gene expression in developing heart and conotruncal tissues PMID: 18028541
    19. These findings findings suggest that FRalpha plays a role in pituitary tumor formation, and this effect may in part be due to its regulation of the NOTCH3 pathway. PMID: 18804697
    20. FOLR1 is a target for regulation by HNF4-alpha in visceral endoderm. PMID: 19180647
    21. Folbp1 may be an important candidate mediator of folic acid deficiency-induced congenital cardiac anomalies which are induced by the dysfunction of proliferation and apoptosis of the myocardial cell PMID: 19212649

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Cytoplasmic vesicle. Cytoplasmic vesicle, clathrin-coated vesicle. Endosome. Apical cell membrane.
  • 蛋白家族：
    Folate receptor family
  • 组织特异性：
    Detected in kidney proximal tubules (at protein level).
  • 数据库链接：

    KEGG: mmu:14275

    STRING: 10090.ENSMUSP00000001882

    UniGene: Mm.2135