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Fen1

Flap endonuclease 1 is a protein in humans that is encoded by FEN1 gene. Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions.

Fen1 Antibodies

Fen1 for Homo sapiens (Human)

Fen1 for Arabidopsis thaliana (Mouse-ear cress)

Fen1 Proteins

Fen1 Proteins for Homo sapiens (Human)

Fen1 Proteins for Mus musculus (Mouse)

Fen1 Proteins for Ovis aries (Sheep)

Fen1 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565) (Filobasidiella neoformans)

Fen1 Proteins for Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) (Filobasidiella neoformans)

Fen1 Proteins for Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1)

Fen1 Proteins for Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / FGSC A1164 / NRRL 181) (Aspergillus fischerianus)

Fen1 Proteins for Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545) (Yeast) (Pichia stipitis)

Fen1 Proteins for Cryptosporidium parvum (strain Iowa II)

Fen1 Proteins for Leishmania infantum

Fen1 Proteins for Leishmania braziliensis

Fen1 Proteins for Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast fungus) (Pyricularia oryzae)

Fen1 Proteins for Ostreococcus lucimarinus (strain CCE9901)

Fen1 Proteins for Tetrahymena thermophila (strain SB210)

Fen1 Proteins for Aspergillus niger (strain CBS 513.88 / FGSC A1513)

Fen1 Proteins for Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii)

Fen1 Proteins for Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus)

Fen1 Proteins for Plasmodium vivax (strain Salvador I)

Fen1 Proteins for Babesia bovis

Fen1 Proteins for Ajellomyces capsulata (strain NAm1 / WU24) (Darling's disease fungus) (Histoplasma capsulatum)

Fen1 Proteins for Nematostella vectensis (Starlet sea anemone)

Fen1 Proteins for Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294) (Kluyveromyces polysporus)

Fen1 Proteins for Giardia intestinalis (strain ATCC 50803 / WB clone C6) (Giardia lamblia)

Fen1 Proteins for Chlamydomonas reinhardtii (Chlamydomonas smithii)

Fen1 Proteins for Brugia malayi (Filarial nematode worm)

Fen1 Proteins for Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003) (Inky cap fungus) (Hormographiella aspergillata)

Fen1 Proteins for Monosiga brevicollis (Choanoflagellate)

Fen1 Proteins for Drosophila erecta (Fruit fly)

Fen1 Proteins for Drosophila persimilis (Fruit fly)

Fen1 Proteins for Drosophila yakuba (Fruit fly)

Fen1 Proteins for Drosophila ananassae (Fruit fly)

Fen1 Proteins for Drosophila grimshawi (Fruit fly) (Idiomyia grimshawi)

Fen1 Proteins for Drosophila mojavensis (Fruit fly)

Fen1 Proteins for Drosophila virilis (Fruit fly)

Fen1 Proteins for Plasmodium knowlesi (strain H)

Fen1 Proteins for Trichoplax adhaerens (Trichoplax reptans)

Fen1 Proteins for Zea mays (Maize)

Fen1 Proteins for Pyrenophora tritici-repentis (strain Pt-1C-BFP) (Wheat tan spot fungus) (Drechslera tritici-repentis)

Fen1 Proteins for Drosophila sechellia (Fruit fly)

Fen1 Proteins for Drosophila simulans (Fruit fly)

Fen1 Proteins for Drosophila willistoni (Fruit fly)

Fen1 Proteins for Penicillium marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)

Fen1 Proteins for Phaeodactylum tricornutum (strain CCAP 1055/1)

Fen1 Proteins for Cryptosporidium muris (strain RN66)

Fen1 Proteins for Penicillium chrysogenum (strain ATCC 28089 / DSM 1075 / Wisconsin 54-1255) (Penicillium notatum)

Fen1 Proteins for Drosophila pseudoobscura pseudoobscura (Fruit fly)

Fen1 Proteins for Enterocytozoon bieneusi (strain H348) (Microsporidian parasite)

Fen1 Proteins for Thalassiosira pseudonana (Marine diatom) (Cyclotella nana)

Fen1 Proteins for Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006) (Penicillium stipitatum)

Fen1 Proteins for Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / NRRL 3357 / JCM 12722 / SRRC 167)

Fen1 Proteins for Salmo salar (Atlantic salmon)

Fen1 Proteins for Osmerus mordax (Rainbow smelt) (Atherina mordax)

Fen1 Proteins for Anoplopoma fimbria (Sablefish)

Fen1 Proteins for Branchiostoma floridae (Florida lancelet) (Amphioxus)

Fen1 Proteins for Uncinocarpus reesii (strain UAMH 1704)

Fen1 Proteins for Entamoeba histolytica

Fen1 Proteins for Pichia pastoris (strain GS115 / ATCC 20864) (Yeast)

Fen1 Proteins for Clavispora lusitaniae (strain ATCC 42720) (Yeast) (Candida lusitaniae)

Fen1 Proteins for Micromonas sp. (strain RCC299 / NOUM17) (Picoplanktonic green alga)

Fen1 Proteins for Glycine max (Soybean) (Glycine hispida)

Fen1 Proteins for Naegleria gruberi (Amoeba)

Fen1 Proteins for Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) (Yeast) (Kluyveromyces thermotolerans)

Fen1 Proteins for Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568 / NRRL Y-229) (Candida mogii)

Fen1 Proteins for Ajellomyces dermatitidis (strain ER-3 / ATCC MYA-2586) (Blastomyces dermatitidis)

Fen1 Proteins for Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell)

Fen1 Proteins for Ajellomyces dermatitidis (strain SLH14081) (Blastomyces dermatitidis)

Fen1 Proteins for Ajellomyces capsulata (strain H143) (Darling's disease fungus) (Histoplasma capsulatum)

Fen1 Proteins for Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)

Fen1 Proteins for Glossina morsitans morsitans (Savannah tsetse fly)

Fen1 Proteins for Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis)

Fen1 Proteins for Nectria haematococca (strain 77-13-4 / ATCC MYA-4622 / FGSC 9596 / MPVI) (Fusarium solani subsp. pisi)

Fen1 Proteins for Phytophthora infestans (strain T30-4) (Potato late blight fungus)

Fen1 Proteins for Arabidopsis thaliana (Mouse-ear cress)

Fen1 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

Fen1 Proteins for Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163) (Aspergillus fumigatus)

Fen1 Proteins for Entamoeba dispar (strain ATCC PRA-260 / SAW760)

Fen1 Proteins for Aspergillus terreus (strain NIH 2624 / FGSC A1156)

Fen1 Proteins for Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Septoria nodorum)

Fen1 Proteins for Aedes aegypti (Yellowfever mosquito) (Culex aegypti)

Fen1 Proteins for Leishmania major

Fen1 Proteins for Trypanosoma cruzi (strain CL Brener)

Fen1 Proteins for Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans)

Fen1 Proteins for Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)

Fen1 Proteins for Plasmodium berghei (strain Anka)

Fen1 Proteins for Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)

Fen1 Proteins for Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)

Fen1 Proteins for Theileria annulata

Fen1 Proteins for Plasmodium chabaudi

Fen1 Proteins for Bos taurus (Bovine)

Fen1 Proteins for Theileria parva

Fen1 Proteins for Ustilago maydis (strain 521 / FGSC 9021) (Smut fungus)

Fen1 Proteins for Trypanosoma brucei brucei (strain 927/4 GUTat10.1)

Fen1 Proteins for Rattus norvegicus (Rat)

Fen1 Proteins for Gallus gallus (Chicken)

Fen1 Proteins for Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / JCM 1990 / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii)

Fen1 Proteins for Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica)

Fen1 Proteins for Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)

Fen1 Proteins for Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) (Yeast) (Torulopsis glabrata)

Fen1 Proteins for Drosophila melanogaster (Fruit fly)

Fen1 Proteins for Plasmodium yoelii yoelii

Fen1 Proteins for Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)

Fen1 Proteins for Plasmodium falciparum (isolate 3D7)

Fen1 Proteins for Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) (Yeast) (Eremothecium gossypii)

Fen1 Proteins for Anopheles gambiae (African malaria mosquito)

Fen1 Proteins for Danio rerio (Zebrafish) (Brachydanio rerio)

Fen1 Proteins for Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite)

Fen1 Proteins for Plasmodium falciparum