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FEN1 Antibody

  • 货号：
    CSB-PA008585LA01DOA
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • Western Blot
      Positive WB detected in Recombinant protein
      All lanes: FEN1 antibody at 1:2000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 37 kDa
      Observed band size: 45 kDa
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Arabidopsis thaliana (Mouse-ear cress) FEN1 Polyclonal antibody
  • Uniprot No.：
    O65251
  • 基因名：
  • 别名：
    FEN1 antibody; At5g26680 antibody; F21E10.3Flap endonuclease 1 antibody; FEN-1 antibody; EC 3.1.-.- antibody; Flap structure-specific endonuclease 1 antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Arabidopsis thaliana
  • 免疫原：
    Recombinant Arabidopsis thaliana Flap endonuclease 1 protein (85-383AA)
  • 免疫原种属：
    Arabidopsis thaliana (Mouse-ear cress)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FEN1 Antibody (CSB-PA008585LA01DOA)，的标记方式是Non-conjugated。对于FEN1 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA008585LB01DOA FEN1 Antibody, HRP conjugated ELISA
    FITC CSB-PA008585LC01DOA FEN1 Antibody, FITC conjugated
    Biotin CSB-PA008585LD01DOA FEN1 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, WB
  • 推荐稀释比：
    Application Recommended Dilution
    WB 1:1000-1:5000
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.
  • 基因功能参考文献：
    1. At5g26680 role in mediating transcriptional gene silencing as well as maintaining genome stability PMID: 27231839
    2. Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity. PMID: 26721386
  • 亚细胞定位：
    Nucleus, nucleolus. Nucleus, nucleoplasm. Mitochondrion.
  • 蛋白家族：
    XPG/RAD2 endonuclease family, FEN1 subfamily
  • 数据库链接：

    KEGG: ath:AT5G26680

    STRING: 3702.AT5G26680.1

    UniGene: At.47103