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  4. Recombinant Human Somatoliberin (GHRH)

Recombinant Human Somatoliberin (GHRH)

  • 货号：
    CSB-YP009412HU
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009412HU
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009412HU-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009412HU
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009412HU
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    GHRH
  • Uniprot No.：
  • 别名：
    GHRF; GHRH; GRF; Growth hormone releasing factor; Growth Hormone Releasing Hormone; Growth hormone-releasing factor; Growth hormone-releasing hormone; INN; MGC119781; OTTHUMP00000030915; Sermorelin; SLIB_HUMAN; Somatocrinin; Somatoliberin; Somatorelin
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Cytoplasmic domain
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
  • 基因功能参考文献：
    1. c.57+1G>A mutation in the GHRH receptor gene is associated with severe and congenital isolated GH deficiency. PMID: 29571594
    2. GHRH stimulates a ligand-independent activation of EGFR involving at least cAMP/PKA and Src family signaling pathways PMID: 27816751
    3. GHRH analogs of the Miami series powerfully suppress tumor growth, but have only a weak endocrine GH inhibitory activity. The suppression of tumor growth could be induced in part by the downregulation of PMID: 28130121
    4. Report a high rate of GHRH-R and GHRH expression in apocrine breast carcinomas. PMID: 28438614
    5. GHRH and GHRH-R loops are involved in placental choriocarcinoma cell line viability and apoptosis through Akt and eIF2a pathways. PMID: 26917260
    6. GHRH excess and blockade in X-LAG syndrome PMID: 26671997
    7. case Report: multiple endocrine neoplasia type 1 family characterized by primary hyperparathyroidism, in association with acromegaly because of ectopic GHRH secretion by a pancreatic neuroendocrine tumor in a young man. PMID: 23542451
    8. After 20 weeks of GHRH administration, gamma-aminobutyric acid levels are increased in all brain regions, N-acetylaspartylglutamate levels are increased in the dorsolateral frontal cortex, and myoinositol levels are decreased in the posterior cingulate. PMID: 23689947
    9. The pathomechanisms involved in the genetic defects at both ends of the GHRH-IGF-1 axis. PMID: 22423511
    10. Pretreatment with GHRH for 12 days could restore pituitary responsiveness to GHRH either in healthy aged men and growth hormone-deficient adult patients. PMID: 20843274
    11. GHRH stimulated the NF-kappa b transcription factor, which is not only known to activate angiogenic factors but also the expression of genes involved in encoding enzymes in the prostaglandin-synthesis pathway such as COX-2 and the iNOS PMID: 20518847
    12. GHRH mutations were not identified in a selected cohort of patients with isolated GH deficiency, suggesting that, if they exist, they may be an extremely rare cause of isolated GH deficiency. PMID: 21715545
    13. The common regenerative and neuroprotective effects of epidermal growth factor (EGF) and growth hormone releasing hormone peptide(GHRP)-6 are associated with their versatile pro-survival and pro-regenerative mechanisms. PMID: 20169434
    14. A single nucleotide polymorphism (SNP) in GnRH shows relationship to central precocious puberty in Chinese Han girls. PMID: 20869425
    15. The present paper will give an overview of the main cardiovascular actions of the ghrelin gene-derived peptides and of GHRH. PMID: 21478211
    16. Data show that GHRH can stimulate the secretion of IL-17 from human peripheral blood mononuclear cells. PMID: 21196925
    17. Results demonstrate that a positive correlation exists between the endocrine potency and the antiproliferative efficacy of GHRH antagonists in tumors strongly expressing pGHRH-R. PMID: 20633588
    18. the juxtapositions between GHRH axonal varicosities may be functional synapses and may represent the morphological substrate of the synchronized release of GHRH in the human hypothalamus. PMID: 20673733
    19. growth hormone-releasing hormone has a role as a growth factor in diverse tissues and various tumors PMID: 20372804
    20. GHRH mRNA was found in transformed human endometriotic stromal cells. PMID: 19524226
    21. human GHRH is expressed in experimental prostate neoplasms in mice; this could explain the effects of GHRH antagonists on growth of prostate cancer PMID: 12126741
    22. expression in gastroenteropancreatic carcinomas PMID: 12186980
    23. expressed in a subset of endometrial tumors, of the endometrioid type in particular; A paracrine/autocrine role for GHRH in the development of the disease should be considered PMID: 12213676
    24. presence of GHRH and its tumoral receptor splice variants in prostate cancers suggests the possible existence of an autocrine mitogenic loop PMID: 12364462
    25. GHRH is essential for the somatotrope cellular proliferation that normally occurs during development-REVIEW PMID: 12424433
    26. Review. Growth hormone-releasing hormone (GHRH) is a hypothalamic hormone that is essential for normal expansion of the somatotrope lineage during pituitary development. PMID: 12511850
    27. autocrine stimulatory loop between GHRH and SV1 variant of GHRH receptor in primary breast cancers PMID: 15362970
    28. Endogenous GHRH is indispensable for the nocturnal augmentation of GH secretion, but that it is unlikely to participate in the genesis of slow-wave sleep. PMID: 15538933
    29. GHRH operates as a growth factor in breast cancer and probably other cancers as well PMID: 17372203
    30. GHRH enhanced the ghrelin-induced GH secretion but had no effect on cortisol secretion PMID: 18329818
    31. Variations in GHRH splice variants may play a role in promoting the development of endometriosis. PMID: 18684444
    32. GHRH interacts with ghrelin receptor GHS-R1a, and, in consequence, modifies the ghrelin-associated intracellular signaling pathway PMID: 19088192
    33. There is a relationship between allelic variation in the gene encoding GHRH and bone density. PMID: 19487270
    34. Our study was conducted on putatively sporadic IGHD patients. Thus, the finding of a dominant mutation with incomplete penetrance is not in contrast with previous reports of a recessive inheritance of GHRHR mutations. PMID: 19622623

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Glucagon family
  • 数据库链接：

    HGNC: 4265

    OMIM: 139190

    KEGG: hsa:2691

    STRING: 9606.ENSP00000237527

    UniGene: Hs.37023