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FKBP10 Antibody

  • 中文名称：
    FKBP10兔多克隆抗体
  • 货号：
    CSB-PA822180LA01HU
  • 规格：
    ￥440
  • 促销：
    小规格抗体限时一口价
  • 图片：
    • IHC image of CSB-PA822180LA01HU diluted at 1:400 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
  • 其他：

产品详情

  • 产品名称：
    Rabbit anti-Homo sapiens (Human) FKBP10 Polyclonal antibody
  • Uniprot No.：
    Q96AY3
  • 基因名：
  • 别名：
    FKBP10 antibody; FKBP65 antibody; PSEC0056Peptidyl-prolyl cis-trans isomerase FKBP10 antibody; PPIase FKBP10 antibody; EC 5.2.1.8 antibody; 65 kDa FK506-binding protein antibody; 65 kDa FKBP antibody; FKBP-65 antibody; FK506-binding protein 10 antibody; FKBP-10 antibody; Immunophilin FKBP65 antibody; Rotamase antibody
  • 宿主：
    Rabbit
  • 反应种属：
    Human
  • 免疫原：
    Recombinant Human Peptidyl-prolyl cis-trans isomerase FKBP10 protein (459-579AA)
  • 免疫原种属：
    Homo sapiens (Human)
  • 标记方式：
    Non-conjugated

    本页面中的产品，FKBP10 Antibody (CSB-PA822180LA01HU)，的标记方式是Non-conjugated。对于FKBP10 Antibody，我们还提供其他标记。见下表：

    可提供标记
    标记方式 货号 产品名称 应用
    HRP CSB-PA822180LB01HU FKBP10 Antibody, HRP conjugated ELISA
    FITC CSB-PA822180LC01HU FKBP10 Antibody, FITC conjugated
    Biotin CSB-PA822180LD01HU FKBP10 Antibody, Biotin conjugated ELISA
  • 克隆类型：
    Polyclonal
  • 抗体亚型：
    IgG
  • 纯化方式：
    >95%, Protein G purified
  • 浓度：
    It differs from different batches. Please contact us to confirm it.
  • 保存缓冲液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 产品提供形式：
    Liquid
  • 应用范围：
    ELISA, IHC
  • 推荐稀释比：
    Application Recommended Dilution
    IHC 1:200-1:500
  • Protocols：
  • 储存条件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

产品评价

靶点详情

  • 功能：
    PPIases accelerate the folding of proteins during protein synthesis.
  • 基因功能参考文献：
    1. FKBP10 interacts with collagen VI and deficiency of FKBP10 reduces lung fibroblast migration by down-regulation of collage VI synthesis. PMID: 29673351
    2. Data found novel mutations of the SERPINF1 and FKBP10 genes in Chinese families with autosomal recessive osteogenesis imperfecta PMID: 29512769
    3. an endoplasmic reticulum complex of resident chaperones that includes HSP47, FKBP65, and BiP regulating the activity of LH2. PMID: 28177155
    4. FKBP10 protein is overexpressed in renal cell carcinoma PMID: 27602571
    5. FKBP65 is linked to pyridinoline cross-linking by specifically mediating the dimerization of LH2. PMID: 27298363
    6. novel pathogenic mutations of FKBP10 can lead to the extremely rare type XI Osteogenesis imperfecta without contractures, which expands the genotypic spectrum of Osteogenesis imperfecta. PMID: 27762305
    7. Mutations in FKBP10, localised to chromosome 17q21, have been identified in a patient of Bruck syndrome. Additional cases are also discussed. PMID: 25931047
    8. A pathogenic change was found in the FKBP10 gene in patients with osteogenesis imperfecta. PMID: 27706701
    9. findings further extend the body of evidence that supports the importance of FKBP10 gene in the development of skeletal system PMID: 26538303
    10. Mutations in the HSP47 and FKBP65 produce a moderately severe form of Osteogenesis imperfect. PMID: 25510505
    11. CTSD, FKBP10, and SLC2A1 are novel genes that participate in the acquisition and maintenance of the adriamycin-resistant phenotype in leukemia cells. PMID: 24467213
    12. Results imply that FKBP10 mutations affect collagen indirectly, by ablating FKBP65 support for collagen telopeptide hydroxylation by lysyl hydroxylase 2, thus decreasing collagen cross-links in tendon and bone matrix. PMID: 23712425
    13. Elastin binding protein and FKBP65 modulate the kinetics of self-assembly of tropoelastin in an in vitro system. PMID: 24106871
    14. FKBP10 depletion enhances glucocerebrosidase proteostasis in Gaucher disease fibroblasts PMID: 23434032
    15. underexpression of FKBP65 protein is characteristic of high-grade serous carcinomas and this expression profile may be linked to molecular pathways associated with an unfavourable outcome in cancer patients. PMID: 23354471
    16. FKBP10 acts during procollagen maturation to contribute to molecular stability and post-translational modification of type I procollagen, without which bone mass and quality are abnormal and fractures and contractures result PMID: 22949511
    17. identified a Palestinian pedigree with moderate and lethal forms of recessive OI caused by mutations in FKBP10 or PPIB, which encode endoplasmic reticulum resident chaperone/isomerases FKBP65 and CyPB, respectively PMID: 22718341
    18. Homozygosity mapping identified FKBP10 as a candidate gene, and sequencing revealed a base pair exchange that causes a C-terminal premature stop codon in this gene. PMID: 22107750
    19. Mutations in FKBP10 cause both Bruck syndrome and isolated osteogenesis imperfecta in humans. PMID: 21567934
    20. The differential expression of FKBP65 indicates a role in ovarian physiology as well as in ovarian tumor development PMID: 21399973
    21. FKBP10 mutations are a cause of recessive osteogenesis imperfecta and Bruck syndrome. PMID: 20839288
    22. Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. PMID: 20362275

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  • 相关疾病：
    Osteogenesis imperfecta 11 (OI11); Bruck syndrome 1 (BRKS1)
  • 亚细胞定位：
    Endoplasmic reticulum lumen.
  • 数据库链接：

    HGNC: 18169

    OMIM: 259450

    KEGG: hsa:60681

    STRING: 9606.ENSP00000317232

    UniGene: Hs.463035