Mouse paired box 6 (PAX6) ELISA kit

Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression.

1. Tgfbeta2, Bmp4 and Foxc1 are direct downstream targets of Pax6 in the developing iris. PMID: 27771509
2. a novel regulatory relationship between the retinal pigmented epithelium (RPE) transcription factors Pax6 and Sox9 that controls the timing of RPE differentiation and the adjacent choroid maturation, is reported. PMID: 29986868
3. overexpression of CHD1L in embryonic cells upregulated the expression of ectoderm genes, especially PAX6 PMID: 28946814
4. Comparative functional analyses revealed that the neurogenic function of Pax6 is highly conserved in the developing mouse and chick pallium, whereas stage-specific binary functions of Pax6 in neurogenesis are unique to mouse neuronal progenitors, consistent with Pax6-dependent temporal regulation of Notch signaling. Pax6-dependent enhancer activity of Dbx1 is extensively conserved between mammals and chick. PMID: 29661783
5. These results demonstrate a novel role for Tlx3 and indicate that Pax6-Tlx3 expression and interaction is part of a region specific regulatory network in cerebellum and its deregulation during development could possibly lead to Autistic spectral disorders (ASD). PMID: 27452274
6. Pax6 (and IBA1) co-localize in the brain and also interact physically. PMID: 28476689
7. Pax6 normally represses Cdca7 expression in the lateral cortex and that repression of Cdca7 in cells of this region is required for their production of a normal complement of Tbr2-expressing intermediate progenitors PMID: 28583079
8. this Pax6 (fl) allele provides a useful addition to the existing Pax6 allelic series and this study demonstrates the utility of using compound heterozygotes with null alleles to unmask cryptic effects of floxed alleles. PMID: 27240603
9. Data show that Pax6 acts in RPCs to control differentiation of multiple late-born neuronal cell types. PMID: 28993200
10. reduced expression of PAX6 in metabolically stressed beta cells may contribute to beta cell failure and alpha cell dysfunction in diabetes. PMID: 27941241
11. The expression of Barhl2 in the thalamus and pretectum is related to, and regulated by, the expression of Pax6. Pax6 is known to be required for normal diencephalic development. The findings suggest that some of its actions might be mediated by its maintenance of a repressive influence over Barhl2 expression in the thalamus and pretectum. PMID: 27887593
12. The present study shows how Pax6 is key to the development of glutamatergic cells in the cerebellum PMID: 27581449
13. These data suggest that Pax6 and Sox2 have counteracting roles in regulating neurogenesis. PMID: 27171428
14. paternal aging has profound effects on the onset of behavioral abnormalities in mice carrying a mutation of Pax6, a gene with neurodevelopmental regulatory functions. PMID: 27855195
15. HDAC1 binds PAX6 and protein-protein interaction leads to transcriptional repression of PAX6 target genes during mouse retinal development PMID: 27871855
16. These results indicate that Pax6 is required for the functional identity of adult beta cells. PMID: 28377501
17. Results showed that multiple sevoflurane exposure in pregnant mice caused the decrease of Pax6 and Ccnd1 expression, the inhibition of NSCs proliferation and fetal hippocampus neurogenesis PMID: 28279665
18. RIP140 protects LSD1's catalytic domain and antagonizes its Jade-2-mediated ubiquitination and degradation. PMID: 26372689
19. Glucose-stimulated expression of ALX3 in alpha cells provides a regulatory mechanism for the downregulation of glucagon gene expression by interfering with PAX6-mediated transactivation on the glucagon G1 promoter element. PMID: 26739814
20. c.718C>T transitional mutation of PAX6 has been found to underlie the aniridia, which showed an autosomal dominant inheritance pattern in this northeastern Chinese family PMID: 27455012
21. novel mutation in the PAX6 gene has been identified in a Chinese family affected with aniridia PMID: 27455013
22. the Pax6 paired domain has roles in neural tube patterning and peripheral nervous system development PMID: 26187199
23. This study demonstrated that Pax6 is expressed in astrocytes and binds to the GLT-1 promoter in vitro and in vivo. PMID: 26485579
24. Pax6 inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker. PMID: 26658466
25. results indicate that Pax6 is required by thalamic progenitors for the normal molecular patterning of the thalamic neurons that they generate PMID: 26520399
26. Pax6 expression is essential for horizontal basal cells to differentiate into neuronal cells during regeneration. PMID: 25808240
27. Upper-layer neuron production was increased in double-transgenic mouse embryos with sustained Pax6 expression in the neurogenic lineage. Increased basal progenitors existed in the subventricular zone and the intermediate zone of the neocortex. PMID: 26252244
28. The expression dynamics shows that Pax6 localizes at XY body during meiotic prophase I, especially in the mid-phase of pachytene spermatocytes which suggests that Pax6 may have some function in inactivation of sex chromosomes during meiosis. PMID: 26032914
29. Study demonstrates that FGFR2 plays an essential role in controlling cell proliferation and differentiation, and maintaining Pax6 levels in corneal epithelium via ERK-independent pathways during embryonic development. PMID: 25615698
30. PAX6 expression in the inner retina of calcitonin receptor-like receptor transgenic (CLR(SMalphaA)) mice suggest a role in regulatory mechanisms involved in glaucoma-related retinal cell death. PMID: 25827297
31. Novel Pax6-dependent gene regulatory network that contribute to the function of Pax6 were identified in both forebrain and lens. PMID: 26138486
32. PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation PMID: 24773074
33. Onecut1 and Onecut2 have roles in operating downstream of Pax6 to regulate horizontal cell development PMID: 25794677
34. deregulation of the cell cycle machinery and TF expression in aOBSCs which are deficient in Pax6 may be at the origin of the phenotypes observed in this adult NSC population. PMID: 25117830
35. Targets of RBPJ/N1ICD in cortical neural stem cell at a genome-wide level, were identified. PMID: 22232070
36. Pax6 blocks diencephalic Shh expression cell autonomously. Absence of Pax6 causes non-cell-autonomous diencephalic patterning defects. PMID: 25176648
37. Retinal pigment epithelium (RPE) of a beta-catenin/Pax6 double mutant was differentiated into the neural retina; however, the tissue was thinner than that of the conditional beta-catenin mutant due to reduced proliferation; data show that Pax6 is required for the RPE differentiation by regulating pigmentation and accountable for hyperproliferation in the transdifferentiated RPE. PMID: 25689933
38. Data (including data from heterozygous Pax6 mutant mouse strain) suggest that Pax6 plays role in development of diabetes type 2 (DM2T); early-onset DM2T can result from interaction of genetic/environmental factors involving Pax6 and high-fat diet. PMID: 24925705
39. The existence of spatial compartmentation in the rhombic lip and the interplay between Wls, Math1, and Pax6 in the rhombic lip provides novel views of early cerebellar development. PMID: 25209290
40. Deletion of either Pax6 in the subependymal zone (SEZ) causes the progeny of adult neural stem cells to convert to the ependymal lineage within the SEZ while migrating neuroblasts convert to different glial lineages en route to or in the olfactory bulb PMID: 23933087
41. Pax6 is a novel downstream target of the Wnt/ss-catenin pathway, and ss-catenin/Pax6 signaling plays critical roles in self-renewal and neurogenesis of radial glia/neural stem cells during neocortical development. PMID: 24115331
42. Pax6 has an evolutionarily conserved function in establishing the temporospatial expression of Shh in the mid-diencephalic organizer in vertebrates. PMID: 24528677
43. The zinc-finger protein Sp8 plays a supplementary role to Pax6 in establishing the pMN/p3 domain boundary. PMID: 24948600
44. functional role of Pax6 loss in SQM pathogenesis PMID: 24143217
45. PAX6, in addition to each patterning function, is expressed in a group of late born interneurons that derive from the p2 and p0 domains. PMID: 23816521
46. Results of the present study suggest that Pax6 is expressed in bone and may play an important role in osteocyte differentiation by controlling canonical Wnt signaling. PMID: 23529217
47. Increased corneal epithelial turnover contributes to abnormal homeostasis in the Pax6(+/-) mouse model of aniridia. PMID: 23967157
48. when Pax6 was inactivated at the onset of contact between the optic vesicle and surface ectoderm in Pax6(Sey/flox) embryos, expression of lens-specific genes was not initiated and neither the lens nor the retina formed PMID: 24523460
49. Manipulation of Pax6 dosage through a mutation-independent nonsense mutation suppression strategy limits progressive, postnatal damage in the eye. PMID: 24355924
50. Mutant PAX6 binds the Pc2 promoter and regulates promoter activity. PMID: 24047795

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Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia.

Nucleus.; [Isoform 1]: Nucleus.; [Isoform 3]: Nucleus. Cytoplasm.; [Isoform 5a]: Nucleus.

Paired homeobox family

Expressed in osteoclasts.; [Isoform 1]: Dominant isoform expressed in the eye, including in the retina and cornea. Abundantly expressed in the lens epithelium.; [Isoform 3]: Dominant isoform expressed in the eye, including in the retina and cornea. Weakly

KEGG: mmu:18508

STRING: 10090.ENSMUSP00000087870

UniGene: Mm.3608