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  4. Recombinant Rat Leukotriene B4 receptor 1 (Ltb4r)

Recombinant Rat Leukotriene B4 receptor 1 (Ltb4r)

  • 货号：
    CSB-CF886424RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Ltb4r; Blt; Leukotriene B4 receptor 1; LTB4-R 1; LTB4-R1
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-351
  • 氨基酸序列
    MAANTTSTAATSSPGGMSLSLLPIVLLSVALVVGLPGNSFVVWSILKRMQKRSVTALLVL NLALADLAVLLTAPFFLHFLARGTWSFEVTGCRLCHYVCGVSMYASVLLITIMSLDRSLA VARPFVSQKVRTKAFARWVLAGIWVVSFLLAIPVLVYRTVTPKNKTLICDSRYPSDGHKV FHLLFEAITGFLLPFLAVVASYSDIGRRLQARRFRRSRRTGRLVVLIILAFAAFWLPYHL VNLVEAGRTLAGWDKNSPAGQRLKLARYVLIALAFLSSSVNPVLYACAGGGLLRSAGVGF VVKLLEGTGSEVSSTRRGGTLVQTPKATPTCPEPGPTDSFMTSSTPPESSK
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response.
  • 基因功能参考文献：
    1. Study verified that both BLT1 mRNA and BLT1 protein expressions were markedly increased after subarachnoid hemorrhage and elevated BLT1 expressions were mainly found in neurons, microglia and endothelial cells rather than astrocytes. We also demonstrated that there a significant positive correlation between BLT1 and nuclear p65 protein expressions in the same specific time course. PMID: 27725151
    2. BLT1 and BLT2 were involved in synovial cell proliferation. PMID: 21189570
    3. LTB4 down-regulates airway contraction and inflammation through activation of the hypothalamic-pituitary-adrenal axis via its BLT1 receptor. PMID: 20403205
    4. The time-dependent expression of Ltb4r in experimental arthritis was studied. PMID: 17481560
    5. FcgammaRI ligation leads to a complex with BLT1 in lipid rafts that enhances rat lung macrophage antimicrobial functions. PMID: 19657115

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Exclusively expressed in polymorphonuclear leukocytes.
  • 数据库链接：

    KEGG: rno:59264

    STRING: 10116.ENSRNOP00000027647

    UniGene: Rn.41003