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  4. Recombinant Rat Histamine H1 receptor (Hrh1)

Recombinant Rat Histamine H1 receptor (Hrh1)

  • 货号：
    CSB-CF010737RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Hrh1; Histamine H1 receptor; H1R; HH1R
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-486
  • 氨基酸序列
    MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHT VGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFI LCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKC ETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLR SDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCF RLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTT DSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIM AAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKK ILHIRS
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    In peripheral tissues, the H1 subclass of histamine receptors mediates the contraction of smooth muscles, increase in capillary permeability due to contraction of terminal venules, and catecholamine release from adrenal medulla, as well as mediating neurotransmission in the central nervous system.
  • 基因功能参考文献：
    1. Data (including data from studies in knockout mice) suggest that sleep-promoting effect of dietary supplement rice bran is dependent on Hrh1 antagonism; rice bran fully inhibits Hrh1 agonist-induced increase in action potential frequency in tuberomammillary nucleus neurons. PMID: 28722302
    2. findings indicate that histamine H1, H2, and H3 receptors are present in rat olfactory epithelium and may play a physiological role in olfactory transmission. PMID: 28964277
    3. This study demonstrates that AITC-induced nociception in vivo depends on TRPA1 and is decreased by the blockade of the NK1 receptor for SP, the H1 receptor for histamine and the 5-HT1A and 3 receptors for 5-HT PMID: 27904941
    4. An H1 receptor blocker did not affect exercise-induced improvement in learning and memory in rats, so these receptors may not play a role in this process. PMID: 25192644
    5. Isolated rat mesenteric collecting lymphatics were treated with 1- to 100-muM histamine. Pharmacologic blockade of either H1 or H2 histamine receptors significantly inhibited the response to histamine. PMID: 24702851
    6. Activation of H1R was required dopaminergic lineage during ventral midbrain development. PMID: 25112718
    7. Na+-Ca2+ exchangers coupled to H1 receptors and hyperpolarization-activated cyclic nucleotide-gated channels linked to H2 receptors co-mediate the strong postsynaptic excitatory action of histamine on al vestibular nucleus neurons PMID: 23713466
    8. These results show that histamine, by activating H(1)R, has a neurogenic effect in clonal conditions PMID: 23497494
    9. Histamine within the nucleus tractus solitarii may play a role in regulating cardiovascular homeostasis via activation of H1 receptors. PMID: 21622829
    10. at the level of the hippocampus, histamine through its H1 and H2 receptors, mediates orofacial region pain PMID: 21602597
    11. H1 receptors play an excitatory role in the modulation of the discharge activities of the inspiratory neurons in neonatal rat brainstem slices. PMID: 20117984
    12. Based on its ability to reverse amphetamine-induced PPI deficits, blockade of histamine H(1) receptors seems to contribute to the therapeutic effect of the antipsychotic clozapine. PMID: 20811878
    13. Studies using various antagonists indicate hippocampal Hrh1 plays an important role in encoding, retention, and retrieval processes of spatial working memory. PMID: 20096284
    14. Activation of H1-receptors in vasopressinergic neurons results in downstream activation of NO synthase, which then mediates the H1-receptor effects. PMID: 12419527
    15. ThEA stimulation evoked amylase release via H1 receptor but was not followed by L-arginine/nitric oxide pathway activation. PMID: 12581497
    16. H1, H2, and H3 histamine receptor mRNA detected in modiolus but not in lateral and medial portions of the cochlea. First evidence of H1, H2, and H3 histamine receptor mRNA in rat cochlea. PMID: 12634496
    17. histamine H(1)-receptor and PKC are involved in the signal transduction pathway, responsible for histamine-stimulated NGF secretion from cultured astrocytes PMID: 15167971
    18. In rat thalamus, histamine H(1) receptor and isoforms of H(3) receptor were expressed predominantly in the midline and intralaminar areas PMID: 15899242
    19. Postischemic increase in H(1) receptor mRNA expression in the caudate-putamen. PMID: 16181737
    20. data represent the first demonstration of H1 receptor expression in sympathetic preganglionic neurons and suggest that histamine acts to regulate excitability of these neurons via a direct postsynaptic effect on H1 receptors PMID: 16354729
    21. Processing of proprioceptive information at the level of the mesencephalic trigeminal neurons is controlled via histamine H1 and H3 receptors through different postsynaptic mechanisms. PMID: 16797837
    22. Results suggest that hippocampal H1 receptors play an important role in working memory processes on radial maze performance and the decrease in hippocampal theta power is associated with the working memory deficit induced by the blocking of H1 receptors. PMID: 17562388
    23. Data show that the synergistic effect of histamine and IL-6 on NGF secretion from cultured astrocytes is evoked by histamine stimulation of IL-6 secretion via a H1-receptor-PKC-MAPK signalling pathway. PMID: 18345501
    24. Data show that cetirizine, a histamine H1 receptor antagonist, decreases the first stage of orthodontic tooth movement in rats. PMID: 18345503
    25. The expression of H1 receptor mRNA was up-regulated in the hypothalamus and brainstem, but not in the cerebral cortex after 2 G hypergravity load in rats. PMID: 18607976
    26. These results suggest that chewing-induced histamine release in the hippocampus and the subsequent H1 receptor activation may be essential to rescue stress-suppressed synaptic plasticity. PMID: 19393269

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: rno:24448

    STRING: 10116.ENSRNOP00000009775

    UniGene: Rn.81032