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  4. Recombinant Rat Calcitonin gene-related peptide type 1 receptor (Calcrl)

Recombinant Rat Calcitonin gene-related peptide type 1 receptor (Calcrl)

  • 中文名称：
    Recombinant Rat Calcitonin gene-related peptide type 1 receptor(Calcrl)
  • 货号：
    CSB-CF730880RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Calcrl; Cgrpr; Calcitonin gene-related peptide type 1 receptor; CGRP type 1 receptor; Calcitonin receptor-like receptor
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-464
  • 氨基酸序列
    ESEEGANQTDLGVTRNKIMTAQYECYQKIMQDPIQQGEGLYCNRTWDGWLCWNDVAAGTE SMQYCPDYFQDFDPSEKVTKICDQDGNWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFY LTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFVCNSIVTIIHLTAVANNQA LVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFP LLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVT HQAESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHYQGLLVSTI FCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDVQGYSHDCPTEHLNG KSIQDIENVALKPEKMYDLVM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for calcitonin-gene-related peptide (CGRP) together with RAMP1 and receptor for adrenomedullin together with RAMP2 or RAMP3. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能参考文献：
    1. Endosomal signaling of the CLR mediates pain transmission. PMID: 29087309
    2. TRPV1 in the lungs and CRLR and NK1R in the brainstem of rats can be upregulated by lung ischemia-reperfusion injury in a rapid manner. PMID: 27338549
    3. Increased expression of IMD and all its receptor components (CRLR, RAMP1, RAMP2, and RAMP3) were displayed within the aorta of rats with Hypercholesterolemia. PMID: 26927337
    4. It is concluded that the expression of gross and surface CRLR and RAMP1 were differentially regulated in primary neuronal cultures following morphine treatments, indicating the involvement of CGRP receptor in morphine associated functions. PMID: 23570731
    5. This study showed that CLR immunoreactivity was observed in satellite glial cells (SGCs) as well as in nerve fibers, but not in neurons. PMID: 22208649
    6. Data suggest that CGRP/CGRP receptor signaling plays role in a rat model of synovitis; blocking CGRP/CGRP receptor signal transduction could provide molecular targeted therapy for synovitis in rheumatoid arthritis or osteoarthritis. PMID: 22233274
    7. Data demonstrate that there is a rich expression of calcitonin gene-related peptide (CGRP) and its receptor elements CLR and RAMP1 in the cerebellum which points towards a functional role of CGRP in cerebellar Purkinje cells. PMID: 21040789
    8. CALCRL protein was found in neuromuscular junctions. Calcrl mRNA level was elevated 6 fold in the muscle endplate. 2 distinct Calcrl messages were alternatively spliced in a non-coding region so that only one translation product is generated. PMID: 21111722
    9. ADM peptide concentration exhibited a spatio-temporal pattern in the rat female reproductive system during gestation and this suggests that ADM may play important roles in gestation. PMID: 21034462
    10. coexpression of CRLR and RAMP2 or RAMP3 mediates the inhibitory effect of adrenomedullin on cell migration, independent of cAMP-dependent signaling pathways. PMID: 12538603
    11. Results showed that mRNA expression of the receptor components was significantly higher in pregnant compared to nonpregnant rats PMID: 12801991
    12. Results demonstrate the presence and cellular localization of calcitonin gene-related peptide receptor components, calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat placenta. PMID: 12837925
    13. Results of study using immunohistochemical and western blot analyses demonstrate high levels of calcitonin receptor-like (CRL) receptor expressed in rat microvascular endothelium. PMID: 14642779
    14. CRLR exists in the nucleus accumbens of intact rats and is significantly upregulated in rats with inflammation. PMID: 15193773
    15. Adrenomedullin and its receptor component (CRLR/RAMP2) mRNAs were concomitantly expressed in various adipose tissues, whose tissue-specific upregulation was induced during the development of obesity. PMID: 15315911
    16. calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1), which constitute a CGRP receptor, were significantly upregulated in mesenteric arteries in the Ang II group PMID: 15643132
    17. Data suggest that intracardiac adrenomedullin and calcitonin receptor-like receptor/receptor activity-modifying proteins (RAMP2 and RAMP3) complexes, are upregulated in volume overload-induced cardiac hypertrophy. PMID: 15680493
    18. CLR and RAMP1 traffic from endosomes to lysosomes by ubiquitin-independent mechanisms, where they are degraded at different rates PMID: 17310067
    19. in trinitrobenzene sulfonic acid-induced colitis, rats with knockdown of CLR displayed a significantly greater degree of edema and necrosis than saline- or control dsRNA-injected rats; this study demonstrates that CLR is a functional receptor for CGRP PMID: 17363466
    20. These findings suggest that CGRP or adrenomedullin receptors modulate opioid release in the dorsal horn. PMID: 17614212
    21. CGRP provoked tachycardia of higher amplitude/longer duration in calcitonin receptor-like receptor transgenic mice, by stimulation of myocardial sympathetic activity. PMID: 17660394
    22. A mechanism by which endosomal ECE-1 degrades neuropeptides in endosomes to disrupt the peptide/receptor/beta-arrestin complex, freeing internalized receptors from beta-arrestins and promoting recycling and resensitization, is proposed. PMID: 18039931
    23. Effects of immobilization on tendon healing were related to changes in the peripheral expression of substance P (NK(1))- and calcitonin gene-related peptide (CRLR and RAMP-1)- receptors PMID: 18655130
    24. mRNA and protein levels of CRLR and were upregulated in spontaneously hypertensive rats PMID: 19041918

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 数据库链接：

    KEGG: rno:25029

    STRING: 10116.ENSRNOP00000006462

    UniGene: Rn.11202