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  4. Recombinant Rat Adenosine receptor A2b (Adora2b)

Recombinant Rat Adenosine receptor A2b (Adora2b)

  • 货号：
    CSB-CF001377RA
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Adora2b; Adenosine receptor A2b
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-332
  • 氨基酸序列
    MQLETQDALYVALELVIAALAVAGNVLVCAAVGASSALQTPTNYFLVSLATADVAVGLFA IPFAITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAIRVPLRYKGLVTGT RARGIIAVLWVLAFGIGLTPFLGWNSKDRATSNCTEPGDGITNKSCCPVKCLFENVVPMS YMVYFNFFGCVLPPLLIMMVIYIKIFMVACKQLQHMELMEHSRTTLQREIHAAKSLAMIV GIFALCWLPVHAINCITLFHPALAKDKPKWVMNVAILLSHANSVVNPIVYAYRNRDFRYS FHRIISRYVLCQTDTKGGSGQAGGQSTFSLSL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
  • 基因功能参考文献：
    1. these results suggested that activation of A2b receptor could be a novel therapeutic approach to high glucose-induced cardiomyocyte injury. PMID: 29626279
    2. Increased A2BAR and adenosine following unilateral lung ischemia as well as more ronchiolitis obliterans organizing pneumonia in A2BAR mutant rats implicate a protective role for A2BAR signaling in countering ischemic lung injury PMID: 28266889
    3. renal fibroblasts express a functional AR1 receptor that inhibits cyclic AMP (cAMP) upon stimulation, leading to a functional AR2B receptor that increases cAMP upon stimulation. PMID: 27466291
    4. Our data indicate varying roles for A(2B)AR signaling in regulating blood pressure in SS rats PMID: 26385692
    5. A2B receptors are downregulated during aging, leading to a reduced adenosine-mediated detrusor relaxation. PMID: 25728851
    6. The findings suggest that adenosine plays a role in signaling transmission via A2bR between taste cells in rats. PMID: 24327108
    7. that stimulation of A2B receptors protects against trauma and hemorrhagic shock -induced lung and muscle injury. PMID: 23584760
    8. Nitric oxide synthase/K+ channel cascade triggers the adenosine A(2B) receptor-sensitive renal vasodilation in female rats PMID: 23396225
    9. The role of the A2B adenosine receptor (AR) in prostate cell death and growth was studied PMID: 23315335
    10. Paracrine Ado A2b receptor signaling contributes to stimulus-evoked catecholamine secretion in hypoxic carotid body chemoreceptors. PMID: 23885058
    11. Hypoxia induced serotonin synthesis and secretion is amplified by ADORA2B signaling via MAPK/CREB and TPH-1 activation. PMID: 23638125
    12. We determined that the adenosine A(2B) receptor (A(2B)AR) mediates VEGF overproduction in ex vivo glomeruli exposed to high glucose concentration, requiring PKCalpha and Erk1/2 activation. PMID: 23069939
    13. 2',3'-cAMP inhibits proliferation of vascular smooth muscle cells from the aorta and coronary arteries. This effect is due in part to metabolism of 2',3'-cAMP to adenosine, with engagement of the A2B receptor. PMID: 21622827
    14. the present study demonstrates that activation of A(2B)AR is strongly cardioprotective in rat heart and suppresses transition pores in isolated cardiomyocytes PMID: 21246204
    15. Endogenously produced luminal surface adenosine increases HCO3- secretion in an intact intestinal epithelium in vivo through the activation of A2B receptors. PMID: 20805305
    16. The A(2B)AR may contribute to the later stages of ischemic preconditioning dependent on the induction of stress-responsive genes. PMID: 20797398
    17. A(2A) and A(2B) receptors are functionally expressed in juxtamedullary afferent arterioles. The powerful vasodilating action of adenosine predominantly involves A(2B) receptor activation, which counteracts A(1) receptor-mediated vasoconstriction. PMID: 20462966
    18. A(2B) receptors may play a critical role in regulating vascular remodeling PMID: 11882603
    19. 1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists PMID: 11906291
    20. Changes in expression of adenosine type-2B (A2B)receptors and a related intracellular second messenger were noted during chronic brain inflammation and following treatment with the NSAID drug flurbiprofen and its nitric oxide-donating derivative, HCT1026 PMID: 12807441
    21. The results show that adenylyl cyclase activation by adenosine and phosphorylation of CREB, but not ERK1/2 or p38, is mainly mediated via the adenosine A(2B) receptor. PMID: 12849998
    22. A2bR are critically involved in adenosine-mediated inhibition of cardiac fibroblast functions. PMID: 15284071
    23. The results suggest that adenosine A 2B- but not beta2-adrenoceptor-mediated facilitation of noradrenaline release is enhanced by an ongoing activation of alpha2-adrenoceptors PMID: 16040158
    24. A(2B) receptors may play role in regulating glomerular remodeling associated with glomerular mesangial cell proliferation. PMID: 16103269
    25. adenosine A(2B) receptor in the posterior hypothalamus plays an inhibitory role in central cardiovascular regulation, and guanylate cyclase mediates the depressor and bradycardiac actions of adenosine A(2B) receptors. PMID: 17363336
    26. These results suggest that purinergic inhibition of taurine efflux from pituicytes operates through A2b receptors coupled to intracellular cAMP increase. PMID: 17391106
    27. proliferation-inhibiting A(2B)AR is itself an inducible receptor regulated by B-Myb. PMID: 17979185
    28. Activation of adenosine A2b receptor results in protein kinase C-alpha-dependent removal of UNC5A from the cell surface. PMID: 17995930
    29. Furthermore, we showed that A(2B)AR activation was necessary to promote a higher expression of VEGF in kidney glomeruli upon exposure to high d-glucose concentration. PMID: 18060864
    30. A(2B) and D(2) receptors interact to modulate the release of catecholamine from rat carotid body. PMID: 19536477

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: rno:29316

    STRING: 10116.ENSRNOP00000003966

    UniGene: Rn.89544