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Recombinant Pig Melanocyte-stimulating hormone receptor (MC1R)

  • 中文名称：
    斯克罗法MC1R重组蛋白
  • 货号：
    CSB-CF886941PI
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    MC1R; Melanocyte-stimulating hormone receptor; MSH-R; Melanocortin receptor 1; MC1-R
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-320
  • 氨基酸序列
    MPVLGPERRLLASLSSAPPAAPRLGLAANQTNQTGPQCLEVSIPDGLFLSLGLVSLVENV LVVAAIAKNRNLHSPMYYFVCCLAVSDLLVSVSNVLETAVLLLLEAGALAAQAAVVQQLD NVMDVLICGSMVSSLCFLGAIAVDRYVSIFYALRYHSIVTLPRAGRAIAAIWAGSVLSST LFIAYYHHTAVLLGLVSFFVAMLALMAVLYVHMLARACQHGRHIARLHKTQHPTRQGCGL KGAATLTILLGVFLLCWAPFFLHLSLVVLCPQHPTCGCVFKNVNLFLALVICNSIVDPLI YAFRSQELRKTLQEVLQCSW
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes.
  • 基因功能参考文献：
    1. A 2-bp insertion (c.67_68insCC) in MC1R causes recessive white coat color in Bama miniature pigs PMID: 28411032
    2. The MC1R gene, located on porcine chromosome 6, is responsible for the Extension coat color locus in Sus scrofa. PMID: 25134014
    3. Melanocortin receptor 1 gene was not the principal factor affecting the coat color differences of Chinese native pig breeds, but could be used to trace the molecular evolution of pig breeds PMID: 15524286
    4. Mutational analysis of the MC1R loci in relation to coat color. PMID: 16734703
    5. Variations in the MC1R gene are associated with coat color. PMID: 16978185
    6. The Chinese Rongchang pig has the dominant black E(D1) allele at the melanocortin 1 receptor (MC1R) locus. PMID: 17150979
    7. Breed specific mutations of the MC1 receptor in an Italian breed of swine. PMID: 17682921
    8. 668G-->C, 1318C-->T, and 1554G-->A may be associated with the recessive red color in the Duroc breed, and nt894insCC making 1197G-->A nonsense may be associated with the white color in Landrace and Yorkshire breeds. PMID: 17884687

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: ssc:494018

    STRING: 9823.ENSSSCP00000027395

    UniGene: Ssc.42761