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  4. Recombinant Pig Follicle-stimulating hormone receptor (FSHR)

Recombinant Pig Follicle-stimulating hormone receptor (FSHR)

  • 货号：
    CSB-CF009021PI
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    FSHR; Follicle-stimulating hormone receptor; FSH-R; Follitropin receptor
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-695
  • 氨基酸序列
    CHHRICHCSNGVFLCQESKVTEIPPDLPRNAVELRFVLTKLRVIPKGAFSGFGDLEKIEI SQNDVLEVIEANVFSNLPKLHEIRIEKANNLLYIDPDAFQNLPNLRYLLISNTGVKHLPA VHKIQSLQKVLLDIQDNINIHTVERNSFVGLSFESMILWLSKNGIREIHNCAFNGTQLDE LNLSDNDNLEELPNDVFQGASGPVILDISRTRIHSLPSYGLENLKKLRAKSTYNLKKLPS LEKFVTLMEASLTYPSHCCAFANWRRQISDLHPICNKSILRQEVDVMTQARGQRVSLAED GESSLAKEFDTMYSEFDYDLCNEVVDVICSPEPDTFNPCEDIMGHDILRVLIWFISILAI TGNIIVLVILITSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKTQYHNYAIDWQ TGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLQCKVQLRHAASIMLVGWIFA FTVALFPIFGISSYMKVSICLPMDIDSPLSQLYVVSLLVLNVLAFVVICGCYTHIYLTVR NPNIMSSSSDTKIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKSKILLVLFYPI NSCANPFLYAIFTKNFRRDVFILLSKFGCYEMQAQTYRTENLSTAHNIHPRNGHCPPAPR ITNSSSYTLIPLSRLAQN
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.
  • 基因功能参考文献：
    1. Activated TGF-beta signaling rescued miR-143-reduced FSHR and intracellular signaling molecules, and miR-143-induced porcine granulosa cell apoptosis. PMID: 27882941
    2. The results showed that polymorphisms in exon 10 of the FSHR gene had a significant effect on litter size traits of Wannan Black and Berkshire pigs. These results can be applied for marker-assisted selection in the 2 swine breeds PMID: 26345751
    3. These results showed that an increased FSHR gene expression level was accompanied with an increase in histone H3K9 acetylation levels, suggesting that histone H3K9 acetylation could regulate the expression of the porcine FSHR gene. PMID: 25599592
    4. This study tested whether prenatal and neonatal exposure to antiandrogen flutamide affected ovarian 17beta-estradiol synthesis and the associated gene expression in large antral follicles of adult pigs. PMID: 23043943
    5. 248 F(2) animals from a Duroc and Meishan cross were genotyped for three FSHR SNPs at positions 74, 532 and 1166, and these were correlated with the phenotypes of litter size and corpus luteum number PMID: 21951899
    6. findings suggest the FSH receptor may be involved in the early follicle formation in pigs, which begins during prenatal life. PMID: 20642491

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family, FSH/LSH/TSH subfamily
  • 数据库链接：

    KEGG: ssc:397679

    STRING: 9823.ENSSSCP00000020856

    UniGene: Ssc.14498