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  4. Recombinant Mouse T-cell surface glycoprotein CD4 (Cd4)

Recombinant Mouse T-cell surface glycoprotein CD4 (Cd4)

  • 货号：
    CSB-CF004935MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd4; T-cell surface glycoprotein CD4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; CD antigen CD4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-457
  • 氨基酸序列
    KTLVLGKEGESAELPCESSQKKITVFTWKFSDQRKILGQHGKGVLIRGGSPSQFDRFDSKKGAWEKGSFPLIINKLKMEDSQTYICELENRKEEVELWVFKVTFSPGTSLLQGQSLTLTLDSNSKVSNPLTECKHKKGKVVSGSKVLSMSNLRVQDSDFWNCTVTLDQKKNWFGMTLSVLGFQSTAITAYKSEGESAEFSFPLNFAEENGWGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQLKETLPLTLKIPQVSLQFAGSGNLTLTLDKGTLHQEVNLVVMKVAQLNNTLTCEVMGPTSPKMRLTLKQENQEARVSEEQKVVQVVAPETGLWQCLLSEGDKVKMDSRIQVLSRGVNQTVFLACVLGGSFGFLGFLGLCILCCVRCRHQQRQAARMSQIKRLLSEKKTCQCPHRMQKSHNLI
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
  • 基因功能参考文献：
    1. data showed the critical role of the first extracellular domain of CD4, by obtaining mice with a loss of function mutation from Ile to Asn at the position 99 of CD4 (I99N). PMID: 29028486
    2. results suggest that CD4 CD8 double knockout (DN)T cells can develop efficiently in vivo and chronic exposure to bacterial superantigens may precipitate a lupus-like autoimmune disease through activation of DNT cells PMID: 28468970
    3. TCF-1-deficient CD4+ CD8+ double positive thymocytes fail to undergo TCR alpha Valpha14-Jalpha18 rearrangement and produce significantly fewer Natural killer T cells. PMID: 25536344
    4. High-fat diet - induced type 2 diabetes decreases the number of ileum IL17/RORgammaT CD4 T cells. PMID: 26154056
    5. Results indicate that hypomethylation of Cd4 antigen correlates with stable CD4 expression. PMID: 26030024
    6. CD4 is expressed in distinct nanoclusters and does not colocalize with T-cell receptor and active protein tyrosine kinase p56lck PMID: 25829544
    7. This study establishes an important role of IgE in abdominal aortic aneurysms pathogenesis by activating CD4+ T cells, mast cells, and macrophages. PMID: 24963147
    8. 5-kb cis-element is required in postselection thymocytes for helper lineage commitment, presumably mediating the maintenance of CD4 expression, and suggest that inactivation of the cis-element by DNA methylation PMID: 24729613
    9. Both type I CD8+ cytotoxic (Tc1) cells and interleukin (IL)-17-producing CD8+ (Tc17) cells mediate effective antitumor immunity through distinct effector mechanisms, but Tc1 cells are superior to Tc17 cells in mediating tumor regression. PMID: 23315072
    10. Accumulation of CD4 positive effector T cells is a critical step in the progression from mild glomerulonephritis to severe crescentic glomerulonephritis accompanied by tubulointerstitial inflammation and loss of kidney function. PMID: 22437418
    11. Thymic selection does not appear to play an important role in CD4+CD8+ T cell receptor (TCR)beta repertoire overlap between individuals. PMID: 22826324
    12. CD4-positive cell deficiency impairs IFN-gamma production by CD8-positive effector cells at the site of Mycobacterium tuberculosis infection in mice. PMID: 22837486
    13. galectin-1 inhibition reduces murine lung metastasis with increased CD4(+) and CD8 (+) T cells and reduced cancer cell adherence PMID: 22484915
    14. Mice that lack the ability to make both CD8-positive and CD4-positive induced regulatory T (iTreg) cells have accelerated graft-vs-host-disease mortality compared with animals that are competent to make both iTreg populations. PMID: 22649199
    15. Danazol induced prolonged cardiac allograft survival and generation of regulatory CD4(+) cells. PMID: 22564626
    16. Hepatic stellate cells seem to act as liver-resident antigen-presenting cells instructing the generation of CD4/CD25/Foxp3(+) regulatory T cells. PMID: 22564624
    17. Thymic or peripheral CD4+ Foxp3+ regulatory T cells cells manifest prominent functional plasticity and readily reprogram into Th1 and Th17 effector cells, particularly in the gut microenvironment or sites of parasitic infection. PMID: 22545118
    18. Both CD4(+) and CD8(+) regulatory T cells appeared to be protective against Graft vs Host Disease - induced lethality and required IL-2 and TGF-beta receptor expression for their generation. PMID: 22496155
    19. SR-A knockout (SR-A(-/-)) mice developed a more robust Cd4(+) T cell response than wild-type mice after ovalbumin immunization. PMID: 22083206
    20. CD4+FoxP3+ regulatory T cells from Galphai2-/- mice are functionally active in vitro, but do not prevent colitis PMID: 21966415
    21. GITR is not required on the surface of CD4-positive T-cells to induce colitis in mice. Knockout mice develop aggravated chronic enterocolitis via an imbalance of colitogenic Th1 cells and Treg cells. PMID: 22155173
    22. leflunomide has an effect on CD4(+)CD25 (+)Foxp3 (+) T regulatory cells in mice receiving allogeneic bone marrow transplantation PMID: 22057872
    23. The average percentage of CD154 expression among CD4+ FoxP3+ T regulatory (Treg) cells was only about 4-9%. PMID: 21496498
    24. AP4 contributes to Cd4 silencing both in DN and CD8(+) T cells by enforcing checkpoints for appropriate timing of CD4 expression and its epigenetic silencing. PMID: 21873191
    25. HMGB1 has the ability to directly modulate the suppressive capacity of CD4(+)CD25(+)Tregs, and TLR4 might be a potential receptor essential for the negative effect of HMGB1 on CD4(+)CD25(+)Tregs activity PMID: 21419643
    26. aged CD4+ T cell function impairment is intimately related to multiple alterations in aged DCs, rather than being caused solely by intrinsic T cell defects PMID: 21453718
    27. Small intestine CD11c+ CD8+ T cells suppress CD4+ T cell-induced immune colitis. PMID: 21436315
    28. Data show that CD8(+) T cell tolerance established in the lung depends only partially on the function of CD4+CD25+Foxp3+ regulatory T cells. PMID: 21518973
    29. anti-TIM3 requires IFN-gamma producing CD8(+) T cells and CD4(+) T cells, and a higher ratio of tumor infiltrating CD8(+):CD4(+) T cells correlating with therapeutic success PMID: 21430066
    30. Prolonged survival of allografts induced by mycobacterial Hsp70 is dependent on CD4+CD25+ regulatory T cells PMID: 21170379
    31. Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells PMID: 20639459
    32. Astragalus membranaceus injection prolonged allograft survival associated with promotion of CD4+ CD25+ Treg activities. PMID: 21094858
    33. Results suggest that CD4+CD25+ Treg cells directly affect cisplatin nephrotoxicity and their modulation represents an additional treatment strategy. PMID: 20463654
    34. Cotransfer of CD8-positiveCD122-positive regulatory T cells (Tregs) clearly suppresses development of colitis, a synergistic effect similar to that of CD4-positiveCD45RB(low) cells that are mostly CD4-positive Tregs. PMID: 21098236
    35. T-cell receptor stimulation of HTLV-1 LTR-Tax transgenic CD4+ T cells induced Tax expression, hyper-proliferation, and immortalization in culture. PMID: 20634377
    36. impairment of Lck-mediated CD4 coreceptor signaling by Nef is an important in vivo mechanism of HIV-1 pathogenesis PMID: 20826747
    37. Pulmonary CD11c+ cells are critical for NO2-promoted allergic sensitization via antigenspecifici CD4+ T-cell polarization. PMID: 20659336
    38. Data describe why ibalizumab has not had adverse immunological consequences in infected patients but also raise possible steric hindrance mechanisms by which this antibody blocks HIV-1 entry into a CD4-positive cell. PMID: 20463063
    39. This significant intracellular storage of LAG-3 appears to facilitate its rapid translocation to the cell surface following T-cell activation, which was much faster for LAG-3 than CD4 PMID: 20391435
    40. Immunosuppressive agents could be successfully combined with in vitro-expanded CD4+CD25+Foxp3+Treg cell therapy to prevent allograft rejection. PMID: 20305583
    41. the proximal enhancer (E4(P)) of Cd4 is essential for CD4 expression in immature CD4(+)8(+) thymocytes PMID: 20360383
    42. Flt3-L significantly inhibited the effect of cockroach antigen sensitization and challenge to increase GATA3 expression in lung CD4(+)CD25(+) T cells. PMID: 19448155
    43. CD4 modulates activity of T cells that express an intermediate affinity, histocompatibility class-I restricted T cell receptor. PMID: 19923452
    44. These results indicate that CD4+CD25+Foxp3+ Tregs modify innate immune responses during resolution of lung injury and suggest potential targets for treating acute lung injury. PMID: 19770521
    45. Glutamic acid decarboxylase-derived epitopes with specific domains expand CD4(+)CD25(+) regulatory T cells PMID: 19759824
    46. miR-155 is shown to be crucially involved in nTreg cell mediated tolerance by regulating the susceptibility of conventional human as well as murine CD4(+) Th cells to nTreg cell-mediated suppression PMID: 19777054
    47. the effects of Deletion of the CD4 silencer element on thymocyte lineage was examined PMID: 11694883
    48. An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis. PMID: 11908949
    49. Relationship between CD34 expression and CD4 expression by hematpoietic stem cells and their long-term reconstitution capability. PMID: 11937272
    50. CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rbeta-deficient mice: implications for the nonredundant function of IL-2 PMID: 12196288

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Highly expressed in T-helper cells. The presence of CD4 is a hallmark of T-helper cells which are specialized in the activation and growth of cytotoxic T-cells, regulation of B cells, or activation of phagocytes. CD4 is also present in other immune cells
  • 数据库链接：

    KEGG: mmu:12504

    STRING: 10090.ENSMUSP00000024044

    UniGene: Mm.2209