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  4. Recombinant Mouse Somatostatin receptor type 5 (Sstr5)

Recombinant Mouse Somatostatin receptor type 5 (Sstr5)

  • 中文名称：
    小鼠Sstr5重组蛋白
  • 货号：
    CSB-CF022728MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Sstr5; Smstr5; Somatostatin receptor type 5; SS-5-R; SS5-R; SS5R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-362
  • 氨基酸序列
    MEPLSLTSTPSWNASAASSSSHNWSLVDPVSPMGARAVLVPVLYLLVCTVGLGGNTLVIY VVLRYAKMKTVTNVYILNLAVADVLFMLGLPFLATQNAVSYWPFGSFLCRLVMTLDGINQ FTSIFCLMVMSVDRYLAVVHPLRSARWRRPRVAKLASAAVWVFSLLMSLPLLVFADVQEG WGTCNLSWPEPVGLWGAAFITYTSVLGFFGPLLVICLCYLLIVVKVKAAGMRVGSSRRRR SERKVTRMVVVVVLVFVGCWLPFFIVNIVNLAFTLPEEPTSAGLYFFVVVLSYANSCANP LLYGFLSDNFRQSFRKALCLRRGYGVEDADAIEPRPDKSGRPQTTLPTRSCEANGLMQTS RL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for somatostatin-28. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Increases cell growth inhibition activity of SSTR2 following heterodimerization.
  • 基因功能参考文献：
    1. mouse somatostatin receptor 5 is sorted by a network of PDZ-domain containing proteins PMID: 24523912
    2. In comparison to wt, ApoD(-/-) mice exhibit increased SSTR5-like immunoreactivity in paraventricular nuclei and decreased receptor expression in ventromedial hypothalamus and arcuate nucleus. PMID: 22581439
    3. Somatostatin inhibited GIP and glucagon-like peptide-1 (GLP-1) secretion from primary small intestinal cultures, in part through SSTR5. PMID: 22872212
    4. SSTR5 is a negative regulator for PDX-1 expression and SSTR5 may mediate the inhibitory effects of somatostatin and its analogs on insulin expression/secretion and cell proliferation via down-regulating PDX-1 PMID: 22669743
    5. The existence of new truncated sst5-variants with unique ligand-selective signaling properties, which could contribute to further understanding the complex, distinct pathophysiological roles of somatostatin and cortistatin. PMID: 20063038
    6. The effect of sst2 receptor knockout on sst5 receptor mRNA localization and binding sites throughout the brain has been determined. PMID: 11897118
    7. the mouse gene promoter has been characterized, and functional activity and nuclear factor interactions were mapped to two specific promoter regions PMID: 12021191
    8. Expression of SSTR3, SSTR4, and SSTR5 in mouse proximal tubules complements the expression of SSTR1 and SSTR2 in collecting ducts as seen in other species PMID: 12472768
    9. results of these studies suggest sst(5) mediates SRIF inhibition of pancreatic insulin secretion and contributes to the regulation of glucose homeostasis and insulin sensitivity PMID: 12511609
    10. A role for SSTR-5 in regulating insulin secretion. PMID: 12657967
    11. in AtT-20 cells, SST5 regulates the dominant SST2 action, attenuating SST2 effects on intracellular calcium oscillation and internalization PMID: 15857828
    12. SSTR5 plays a pivotal role in the regulation of insulin secretion in the mouse pancreas PMID: 15919085
    13. results suggest that somatostatin receptor 5(SSTR5) plays a pivotal role in insulin secretion and glucose regulation in mice and that its regulatory effects are age-related PMID: 16026801
    14. we identified 2 sets of SSTR5 regulated pancreatic genes in SSTR5 deficient mice that belong to the pathways regulating cell proliferation, apoptosis neogenesis, angiogenesis, and tumorigenesis. PMID: 19137362

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Expressed in adult brain but not in liver, heart, spleen, or kidney.
  • 数据库链接：

    KEGG: mmu:20609

    STRING: 10090.ENSMUSP00000051085

    UniGene: Mm.353282