Sstr5
SSTR5，即生长抑素受体5，别名生长抑素受体亚型5、SS5-R、Somatostatin receptor type 5等。SSTR5是一种G蛋白偶联受体(GPCRs)，主要在垂体中高度表达，参与调控多种激素的分泌，如促肾上腺皮质激素、催乳素和生长激素等。SSTR5的作用机制涉及到与其天然配体生长抑素(SST)或合成激动剂药物如奥曲肽(octreotide)结合，进而抑制腺苷酸环化酶(AC)的活性，通过抑制性G蛋白(Gi)介导，调控胞内cAMP浓度，影响激素的分泌和肿瘤生长等过程 。SSTR5在生物学上的意义主要体现在其作为多种内分泌疾病和肿瘤治疗的潜在靶点。SSTR5的激活可以减少胆囊收缩，增加胆固醇性胆结石的风险，因此，拮抗SSTR5可能会促进胆囊排空，减少胆囊结石的形成 。此外，SSTR5的表达水平与某些癌症的发病有关，例如研究发现SSTR5基因的变异与头颈部癌、肺癌、前列腺癌和肾癌等癌症的发病有关 。因此，SSTR5不仅在调控激素分泌和肿瘤生长中发挥重要作用，也是药物开发和疾病治疗中的潜在靶点。
热销产品
Recombinant Human Somatostatin receptor type 5 (SSTR5), partial (CSB-EP022728HU1)
验证数据
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
验证数据
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA254587(SSTR5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA254587(SSTR5 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
Gel: 10%SDS-PAGE, Lysate: 60 μg, Lane: Mouse thymus tissue, Primary antibody: CSB-PA254587(SSTR5 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds
Sstr5 Antibodies
Sstr5 for Homo sapiens (Human)
| 产品货号 | 产品名称 | 种属反应性 | 应用类型 |
|---|---|---|---|
| CSB-PA022728GA01HU | SSTR5 Antibody | Human,Mouse | ELISA,WB |
| CSB-PA254587 | SSTR5 Antibody | Human,Mouse | ELISA,WB,IHC |
| CSB-PA997043 | SSTR5 Antibody | Human | ELISA,WB |
Sstr5 Proteins
Sstr5 Proteins for Rattus norvegicus (Rat)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP022728RA1 CSB-EP022728RA1 CSB-BP022728RA1 CSB-MP022728RA1 CSB-EP022728RA1-B |
Recombinant Rat Somatostatin receptor type 5 (Sstr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF022728RA | Recombinant Rat Somatostatin receptor type 5 (Sstr5) | in vitro E.coli expression system |
Sstr5 Proteins for Homo sapiens (Human)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP022728HU1 CSB-BP022728HU1 CSB-MP022728HU1 CSB-EP022728HU1-B |
Recombinant Human Somatostatin receptor type 5 (SSTR5), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF022728HU | Recombinant Human Somatostatin receptor type 5 (SSTR5) | in vitro E.coli expression system |
| CSB-EP022728HU1 | Recombinant Human Somatostatin receptor type 5 (SSTR5), partial | E.coli |
Sstr5 Proteins for Mus musculus (Mouse)
| 产品货号 | 产品名称 | 来源 |
|---|---|---|
| CSB-YP022728MO1 CSB-EP022728MO1 CSB-BP022728MO1 CSB-MP022728MO1 CSB-EP022728MO1-B |
Recombinant Mouse Somatostatin receptor type 5 (Sstr5), partial | Yeast E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-CF022728MO | Recombinant Mouse Somatostatin receptor type 5 (Sstr5) | in vitro E.coli expression system |
