Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Orexin receptor type 2 (Hcrtr2)

Recombinant Mouse Orexin receptor type 2 (Hcrtr2)

  • 中文名称：
    小鼠Hcrtr2重组蛋白
  • 货号：
    CSB-CF010232MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Hcrtr2; Mox2r; Orexin receptor type 2; Ox-2-R; Ox2-R; Ox2R; Hypocretin receptor type 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-460
  • 氨基酸序列
    MSSTKLEDSLSRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVS CIIMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMI LAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARR KTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAAN PIIYNFLSGKFREEFKAAFSCCLGVHHRQGDRLARGRTSTESRKSLTTQISNFDNVSKLS EHVVLTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
  • 基因功能参考文献：
    1. In an heart failure model, HCRTR2-deficient mice exhibited poorer cardiac function, worse treadmill exercise capacity, and greater myocardial scarring PMID: 26653627
    2. orexin activation of OX2R in the brain centrally enhances bone formation by lowing circulating leptin level. PMID: 24794976
    3. Knocking down the Orx2 receptors in the basolateral amygdala increased anxious behavior as measured by reduced social preference and reduced time spent in the center of an open field. PMID: 24485472
    4. OX2R activation induces PKC-mediated ERK and CREB phosphorylation. PMID: 22652455
    5. In the hypothalamus, the OX2 receptors have an inhibitory role in modulating basal concentrations of NE, ACh, and Hist. In the prefrontal cortex, the evoked release of the monoamines NE, 5-HT, and DA seems to be controlled negatively by OX2 receptors. PMID: 22038504
    6. Mice lacking OX2R signaling had poor maintenance of wakefulness indicative of sleepiness and fragmented sleep and lacked any electrophysiological response to orexin-A in the wake-promoting neurons of the tuberomammillary nucleus. PMID: 21368172
    7. activation of orexin neurons through OX2R might have an important role in the maintenance of arousal. PMID: 20861370
    8. Regulation of sleep/wake states is completely achieved by OX(2)R-expressing neurones without involving H(1)R-mediated pathways. Maintenance of basal physiological sleep/wake states is fully achieved without both H(1) and OX(1) receptors. PMID: 19694625
    9. So, the SAF diet can alter adipocytic adiposity-related gene expression and result in effective amelioration of diet-induced obesity. PMID: 20213045
    10. hypocretin receptor 2 mRNA levels declined with age in the hippocampus, thalamus, pons, and medulla (hypocretin receptor 2) PMID: 12399012
    11. OX2alphaR is expressed in various areas of the mouse brain and has low expression in caudal part of cerebellum PMID: 16806113
    12. The enhanced orexin-orexin receptor2 signaling confers resistance to diet-induced features of the metabolic syndrome through negative energy homeostasis and improved leptin sensitivity. PMID: 19117547
    13. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. PMID: 19751316

    显示更多

    收起更多

  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Widely expressed. Isoform 2 not detected in skeletal muscle and kidney.
  • 数据库链接：

    KEGG: mmu:387285

    STRING: 10090.ENSMUSP00000058230

    UniGene: Mm.335300