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  4. Recombinant Mouse Junctional adhesion molecule A (F11r)

Recombinant Mouse Junctional adhesion molecule A (F11r)

  • 货号：
    CSB-CF007917MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    F11r; Jam1; Jcam; Jcam1; Junctional adhesion molecule A; JAM-A; Junctional adhesion molecule 1; JAM-1; CD antigen CD321
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-300
  • 氨基酸序列
    KGSVYTAQSDVQVPENESIKLTCTYSGFSSPRVEWKFVQGSTTALVCYNSQITAPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEEGGQNYGEVSIHLTVLVPPSKPTISVPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGISMLTADAKKTRAFMNSSFTIDPKSGDLIFDPVTAFDSGEYYCQAQNGYGTAMRSEAAHMDAVELNVGGIVAAVLVTLILLGLLIFGVWFAYSRGYFERTKKGTAPGKKVIYSQPSTRSEGEFKQTSSFLV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. Involved in platelet activation.
  • 基因功能参考文献：
    1. Deletion JAM-A from platelets increases early-stage neointima formation after carotid artery wire injury in hyperlipidemic mice. PMID: 28211187
    2. JAM-A is present in the prostate and seminal vesicles and in all three regions of the epididymis where it is secreted in epididymosomes in the luminal fluid and can be delivered to sperm. PMID: 28062807
    3. Soluble JAM-A secreted from cardiac progenitor cells reduces infiltration of neutrophils after myocardial infarction and ameliorates tissue damage through prevention of excess inflammation. PMID: 25468657
    4. JAM-A up-regulation can increase the proliferation, cytokine secretion and wound-homing ability of MSCs, thus accelerating the repair rate of full-thickness skin defects PMID: 25994236
    5. Endothelial JAM-A but not hematopoietic JAM-A facilitates reovirus T1L bloodstream entry and egress. PMID: 25149763
    6. Deletion of JAM-A causes a gain-of-function in platelets, with lower activation thresholds and increased inflammatory activities. This leads to an increase of plaque formation, particularly in early stages of the disease. PMID: 25472975
    7. The F11r gene is directly regulated by retinoic acid in the embryonic mesoderm. PMID: 25251699
    8. Redistribution of JAM-A in endothelial cells after stimulation with pro-atherogenic oxidized lipoproteins results in increased transmigration of mononuclear cells. PMID: 24704627
    9. JAM-A has a prominent role in regulating leukocyte infiltration after brain I/R injury and could be a new target in limiting post-ischemic inflammation. PMID: 24657919
    10. JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton. PMID: 23885123
    11. Cancer stem cells selectively express JAM-A, which regulates self-renewal. PMID: 24373972
    12. These studies establish F11R as a novel monocyte prognostic marker for GBM critical for defining a subpopulation of stromal cells for future potential therapeutic intervention. PMID: 24147027
    13. Our data identify endothelial JAM-A as an important effector molecule integrating atherogenic conditions to direct inflammatory cell entry at predilection sites of atherosclerosis. PMID: 24065611
    14. The JAM-A and ZO-1 genes were highly expressed in all the tested tissues. PMID: 23568966
    15. Junctional adhesion molecule-A regulates vascular endothelial growth factor receptor-2 signaling-dependent mouse corneal wound healing. PMID: 23667656
    16. The crucial role of JAM-A in the transmigration of neutrophils from the vasculature into inflamed tissues. PMID: 22904169
    17. The chemokine (C-C motif) ligand 2 (CCL2) induced JAM-A redistribution from the interendothelial cell area to the apical surface of brain endothelial cells. PMID: 22733993
    18. CASK negatively regulates PMCA4b by directly binding to it and JAM-A positively regulates it indirectly through CASK PMID: 22020416
    19. JAM-A normally limits platelet accumulation by inhibiting integrin outside-in signaling thus preventing premature platelet activation. PMID: 22271446
    20. Data suggest that aPKC phosphorylates JAM-A at S285 to regulate cell-cell contact maturation, TJ formation, and single lumen specification. PMID: 22371556
    21. downregulation of JAM-A reduces tumor aggressive behavior by increasing cell susceptibility to apoptosis PMID: 21695058
    22. Data demenstrate that JAM-A restricts intestinal epithelial cell (IEC) proliferation in a dimerization-dependent manner, by inhibiting Akt-dependent beta-catenin activation. PMID: 21372850
    23. Our data show that JAM-A is a novel surface marker for NG2-glia cells of the adult brain. PMID: 20184779
    24. In the Rip1Tag2 tumor model, abrogation of JAM-A reduces cancer development by increasing antitumor immune response. PMID: 20160037
    25. JAM-1 did not contribute to global embryo compaction and adhesion but rather regulated the timing of blastocoel cavity formation dependent upon establishment of the trophectoderm tight junction paracellular seal. PMID: 15494378
    26. By regulating cytoskeletal and adhesive structures, JAM-A expression prevents cell motility, probably in a PSD95-Dlg-ZO1-dependent manner. PMID: 15657074
    27. JAM-A is up-regulated in hepatic venules and serves as an endothelial receptor of neutrophil transmigration, but it does not mediate leukocyte rolling, adhesion, or platelet-endothelial cell interactions. PMID: 15827135
    28. JAM-A is required for the correct infiltration of polymorphonuclear leukocytes into an inflamed peritoneum or in the heart upon ischemia-reperfusion injury. PMID: 16027360
    29. crucial role of JAM-A in accelerated lesion formation and monocyte infiltration in atherosclerosis-prone mice PMID: 16306427
    30. Taken together, these data indicate that JAM-A regulates cell motility by cooperating with microtubule-stabilizing pathways. PMID: 16783819
    31. Essential role for JAM-A in FGF-2-induced angiogenesis. PMID: 16809549
    32. JAM-A is expressed in the corneal epithelium where it appears to regulate cell shape. PMID: 17118692
    33. Junctional adhesion molecule-A is critical for the formation of pseudocanaliculi and modulates E-cadherin expression in hepatic cells PMID: 17623668
    34. JAM-A is expressed on hematopoietic precursors in various hematopoietic tissues PMID: 17986666
    35. The findings show that JAM-A is involved in sperm tail formation and is essential for normal motility, which may occur via its signal transduction and protein phosphorylation properties. PMID: 18022613
    36. JAM-A plays a role in intestinal homeostasis by regulating epithelial permeability, inflammation, and proliferation PMID: 18039951
    37. A short bond lifetime imparts a highly dynamic nature to homophilic JAM-A interactions for regulating tight junction permeability while stable interactions between sigma1 and JAM-A likely anchor the virus to the cell surface and facilitate viral entry. PMID: 18446885
    38. nonredundant and novel role of JAM-A in controlling mucosal homeostasis by regulating the integrity and permeability of epithelial barrier function PMID: 18514073
    39. Nectin plays a novel role in the co-localization of JAM and claudin at the same cell-cell adhesion membrane domains. PMID: 18547333
    40. These data indicate that JAM-A is required for the correct internalization and recycling of integrins during cell migration. PMID: 19118219
    41. The s inoculated wild-type (WT) and isogenic JAM-A(-/-) mice perorally with reovirus and found that JAM-A is dispensable for viral replication in the intestine but required for systemic dissemination. PMID: 19154988

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Single-pass type I membrane protein. Note=Localized at tight junctions of both epithelial and endothelial cells.
  • 蛋白家族：
    Immunoglobulin superfamily
  • 数据库链接：

    KEGG: mmu:16456

    STRING: 10090.ENSMUSP00000041907

    UniGene: Mm.294882