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  4. Recombinant Mouse Interleukin-5 receptor subunit alpha (Il5ra)

Recombinant Mouse Interleukin-5 receptor subunit alpha (Il5ra)

  • 货号：
    CSB-CF011663MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Il5ra; Il5r; Interleukin-5 receptor subunit alpha; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA; CD antigen CD125
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    18-415
  • 氨基酸序列
    DLLNHKKFLLLPPVNFTIKATGLAQVLLHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSSHTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDAPEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKRAAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNTKNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKSLVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSNETKIEVVHCVEEVGFEVMGNSTF
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is the receptor for interleukin-5. The alpha chain binds to IL5.
  • 基因功能参考文献：
    1. SLy2 controls the antibody response to pneumococcal vaccine through an IL-5Ralpha-dependent mechanism in B-1 cells. PMID: 25330943
    2. Deglycosylated variant Il5ralpha has the same ligand binding affinity and biological activity as fully glycosylated IL5Ralpha, thus demonstrating a unique role for Asn196 glycosylation in IL5Ralpha function. PMID: 21770429
    3. Interleukin-5 receptor alpha chain expression and splicing during brain development in mice. PMID: 11811788
    4. Octamer Transcription Factor 2 (Oct2) augments the ability of activated B cells to differentiate to antibody-secreting plasma cells under T cell-dependent conditions through regulation of the gene encoding the interleukin 5 receptor alpha chain. PMID: 18250192
    5. We identified B-1 progenitors expressing low levels of IL-5 receptor alpha chain (IL-5Ralpha) and eosinophil progenitors expressing higher levels of IL-5Ralpha in the fetal liver PMID: 19428566
    6. The murine interleukin-5 receptor alpha chain pre-mRNA is alternatively spliced, resulting in soluble isoforms lacking the transmembrane coding region which do not complex with the IL-5R beta chain. PMID: 11425312

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed on eosinophils and basophils. Also on B-cells.
  • 数据库链接：

    KEGG: mmu:16192

    STRING: 10090.ENSMUSP00000129781

    UniGene: Mm.3448