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  4. Recombinant Mouse Gonadotropin-releasing hormone receptor (Gnrhr)

Recombinant Mouse Gonadotropin-releasing hormone receptor (Gnrhr)

  • 货号：
    CSB-CF009637MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Gnrhr; Gonadotropin-releasing hormone receptor; GnRH receptor; GnRH-R
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-327
  • 氨基酸序列
    MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKL QKWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL KLFSMYAPAFMMVVISLDRSLAITQPLAVQSNSKLEQSMISLAWILSIVFAGPQLYIFRM IYLADGSGPTVFSQCVTHCSFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRV LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMLNRVS EPVNHFFFLFAFLNPCFDPLIYGYFSL
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能参考文献：
    1. leptin's direct stimulatory actions on gonadotrope GnRHR correlate with a direct inhibition of expression of the posttranscriptional regulator MSI1. There also is a direct MSI1 interaction with 3'-UTR of Gnrhr mRNA. PMID: 29228137
    2. the age-dependent basal and regulated Gnrhr transcription could account for the initial blockade and subsequent activation of the reproductive system during development. PMID: 27569529
    3. GnRH-GnRHR system is not essential for growth or motor/sensory/orientation behavior during the first month of life prior to puberty onset. The lack of the GnRH-GnRHR axis, however, did affect females resulting in reduced subcutaneous inguinal fat pad weight and increased glucose with possible insulin resistance. PMID: 28346489
    4. His305 of the GnRH receptor forms two distinct interactions that determine binding to GnRH and couple agonist binding to the conserved transmembrane domain network that activates GPCRs. PMID: 25583361
    5. Data confirm that Gnrhr mRNA and protein are expressed in ovaries, granulosa cells, cumulus cells, and oocytes. PMID: 23913446
    6. Msx1 functions as a negative regulator early in pituitary development by repressing the gonadotrope-specific alphaGSU and GnRHR genes. PMID: 23371388
    7. These results suggest decreased GnRH receptor signaling in the mutant animal, compared with wild type. PMID: 22918878
    8. GnRHR neurons were found in different brain areas. Many GnRHR neurons were identified in areas influencing sexual behaviors PMID: 21303944
    9. A comprehensive knowledgebase of the GnRHR signaling in the LbetaT2 cell, was curated. PMID: 20592162
    10. Null Gnrhr mice had small sexual organs, low levels of FSH, LH, and steroid hormones, failure of sexual maturation, infertility, and inability to respond to exogenous GnRH. PMID: 20068010
    11. GnRH and dex synergistically activate the endogenous GnRHR promoter in L beta T2 cells PMID: 19812390
    12. role of regulatory elements and their cognate transcription factors in transactivation of the mGnRHR gene PMID: 12145309
    13. an intact AP-1 element is necessary for GnRH responsiveness of the GnRHR gene; results suggest a critical role for JNK in mediating GnRH regulation of the GnRHR gene PMID: 12586760
    14. the GnRH receptor activating sequence is a composite regulatory element whose functional activity is dependent on the organization of a multi-protein complex consisting of Smads, AP-1 and a member of the forkhead family of DNA binding proteins PMID: 12943993
    15. Results suggest that pituitary homeobox 1 (Pitx-1) can direct transactivation of the mouse gonadotropin-releasing hormone receptor gene, in part by DNA binding and in part by an action of Pitx-1 as a cofactor for AP-1 [Pitx-1]. PMID: 15226417
    16. NF-Y and Oct-1 bind to the SURG-1 element to direct basal and GnRH-stimulated expression of the mGnRHR gene PMID: 15388790
    17. An autosomal-recessive mutation leucine to proline that causes hypogonadotrophic hypogonadism was isolated during an N-ethyl-N-nitrosourea mutagenesis screen in mice. PMID: 15625238
    18. Regulatory elements defined as the activin/TGFbeta-responsive "enhanceosome" were show in the promoter of the murine GnRHR gene. PMID: 15637149
    19. study demonstrates a functional role for LHX3 in the regulation of the GnRH receptor PMID: 15705775
    20. there are species-specific dominant negative receptor trafficking effects of the GnRHR between human, rat and mouse PMID: 15886197
    21. co-transfection of DAN markedly inhibited the synergistic activation of GnRH and activin on GnRH receptor gene expression thus implicating DAN as a novel autocrine/paracrine factor that modulates GnRH function in pituitary gonadotropes. PMID: 17914181
    22. These data implicate the clock genes as important factors controlling GnRHR expression in murine gonadotrope cells. PMID: 17928134
    23. We have defined the proportion of GnRHRs at the cell surface. PMID: 18252959
    24. NeuroD1 and Mash1 temporally regulate GnRH receptor gene expression in immortalized mouse gonadotrope cells. PMID: 18760324
    25. The two most proximal homeodomain-binding sites in the murine GnRHR promoter may regulate the promoter in a developmentally dependent fashion. PMID: 19333792
    26. Pulsatile and sustained gonadotropin-releasing hormone (GnRH) receptor signaling: does the Ca2+/NFAT signaling pathway decode GnRH pulse frequency PMID: 19858197

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 组织特异性：
    Pituitary gland.
  • 数据库链接：

    KEGG: mmu:14715

    STRING: 10090.ENSMUSP00000031172

    UniGene: Mm.26791