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  4. Recombinant Mouse 5-hydroxytryptamine receptor 4 (Htr4)

Recombinant Mouse 5-hydroxytryptamine receptor 4 (Htr4)

  • 货号：
    CSB-CF010895MO
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    Htr4; 5-hydroxytryptamine receptor 4; 5-HT-4; 5-HT4; Serotonin receptor 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-388
  • 氨基酸序列
    MDKLDANVSSNEGFRSVEKVVLLTFLAVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIV SLAFADLLVSVLVMPFGAIELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYY AICCQPLVYRNKMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSN STWCVFMVNKPYAITCSVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGATSESRP QPADQHSTHRMRTETKAAKTLCVIMGCFCFCWAPFFVTNIVDPFIDYTVPEQVWTAFLWL GYINSGLNPFLYAFLNKSFRRAFLIILCCDDERYKRPPILGQTVPCSTTTINGSTHVLRD TVECGGQWESRCHLTATSPLVAAQPSDT
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase.
  • 基因功能参考文献：
    1. Prefrontal cortex 5-HT4Rs mediate hypophagia following stress. PMID: 29069597
    2. Study shows that in the murine gastrointestinal tract, activation of 5-HT4 receptors with prucalopride enhances cholinergic contractions, illustrating facilitation of myenteric cholinergic neurotransmission. PMID: 28332745
    3. These data suggest that correlated expression of Slc6a4 and Htr4 likely involves coregulation of genes located on different chromosomes which modulate serotonergic activity in the gut. PMID: 27072889
    4. altered 5-HT4R expression may affect the development of cortical glutamatergic control of the dorsal raphe nucleus. PMID: 28108396
    5. Results demonstrate that the absence of 5-HT4 receptors triggers adaptive changes that could maintain emotional states, and that the behavioural and molecular effects of fluoxetine under pathological depression appear to be critically dependent on 5-HT4 receptors. PMID: 27586007
    6. HTR4's role in pulmonary function likely relates to neural innervation and control of breathing. PMID: 28130264
    7. 5-HT4 receptor regulating insulin secretion and acting as a potential drug target in diabetes treatment PMID: 27423314
    8. Its activation facilitates neurogenesis of injured enteric neurons.(review) PMID: 26658112
    9. The findings of altered lung function and increased AHR in Htr4-null mice support a causal relationship between genetic variation in HTR4 and pulmonary function identified in human genome-wide association studies. PMID: 25342126
    10. Our in vivo data using pharmacologic and genetic approaches suggest that 5-HT(4) receptors are not involved in the bronchial hyperresponsiveness to 5-HT in cigarette smoke-exposed mice PMID: 24183679
    11. A highly conserved motif in the ligand-binding pocket of serotonin receptors is an important participant in ligand binding. PMID: 23378516
    12. These results suggest a prominent role of 5-HT(4)R in promoting angiogenesis. PMID: 22903372
    13. Endogenous 5-HT exerts a dual role in the pathogenesis of indomethacin-induced intestinal lesions: pro-ulcerogenic action via 5-HT3 receptors and anti-ulcerogenic action via 5-HT4 receptors. PMID: 22699012
    14. This review presented that the 5HT4 RECEPTOR knockout mice show a correlation between 5-HT firing rate and depressive/resilience phenotypes. PMID: 23089640
    15. These results show that prenatal stress and reduced 5-HT levels can alter 5-HT(4)R expression in the developing forebrain and that some 5-HT(4)R splice variants. PMID: 22564922
    16. This study demonistrated that alternatively spliced multiple transcripts of 5-hydroxytryptamine receptor expression in heart. PMID: 22079627
    17. Mucosal 5-HT(4) receptor activation can mediate the prokinetic and antinociceptive actions of 5-HT(4)R agonists. PMID: 22226658
    18. G protein activation by serotonin type 4 receptor dimers: evidence that turning on two protomers is more efficient. PMID: 21247891
    19. -HT-R splice variants and beta-ARs are differentially regulated in the embryonic telencephalon PMID: 20805681
    20. adaptive changes in cholinergic systems may circumvent the absence of 5-HTR(4) to maintain long-term memory under baseline conditions PMID: 20209108
    21. After bulbectomy, 5-HT(4) receptor binding was increased in the ventral hippocampus but unchanged in the dorsal hippocampus, frontal and caudal caudate putamen PMID: 20060867
    22. These results suggest that during development 5-HT4-R expression undergoes a dynamic regulation and that this regulation may be important for the normal development of sensory and limbic processing. PMID: 19998416
    23. 5-HT4 receptor knock-out mice have an attenuated response to stress and increased susceptibility to seizures. PMID: 14724239
    24. The mechanisms underlying feeding disorders in 5-HT4 receptor knockout mice are related to a lesser efficacy of 5-HT (hypothalamus, nucleus accumbens), leptin and the cocaine-amphetamine related transcript to reduce food intake following stress. PMID: 15146954
    25. SNX27 and NHERF specifically interact with the 5-HT4a receptor splice variant PMID: 15466885
    26. the uncoupling and endocytosis of 5-HT4R require different GRK2 concentrations and involve distinct molecular events PMID: 15919661
    27. 5-HT(4a), 5-HT(4b), 5-HT(4e), and 5-HT(4f) isoforms were found in mouse brain and gut. Enteric neuronal 5-HT(4) receptors thus are presynaptic and probably exert their prokinetic effects by strengthening excitatory neurotransmission. PMID: 16037544
    28. Results describe the adaptive changes in serotonin neurons of the raphe nuclei in 5-HT(4) receptor knock-out mouse. PMID: 16930432
    29. These and previous data collectively suggest that the 5-HT4 receptor may be an effective therapeutic target for AD, providing both symptomatic improvements and neuroprotection. PMID: 16978609
    30. Activation of colonic myenteric neurons in the 5-HT4 receptor-mediated colonic propulsive motor response. PMID: 16990446
    31. Data show that 5-HT(4) receptor stimulation in primary neurons produced a potent but transient activation of the ERK pathway that is dependent on Src tyrosine kinase but totally independent of beta-arrestin. PMID: 17377064
    32. Serotoninergic 5-HT4 receptor plays an important role in mouse fetal development; in BALB/c mice there is a direct relation between its expression and the deleterious effect of maternal anti-5-HT4 receptor autoantibodies in early embryogenesis. PMID: 17445258
    33. These findings provide evidence that 5-HT(4)Rs stimulation selectively increases experience-dependent structural plasticity in learning-activated hippocampal circuits. PMID: 18075492
    34. Essential role of p11 in modulating signaling through 5-HT4 as well as 5-HT1B receptors supports the concept of p11 protein as a key determinant of vulnerability to depression. PMID: 19211900
    35. This is the first demonstration of adult enteric neurogenesis; our results suggest that 5-HT(4) receptors are required postnatally for enteric nervous system growth and maintenance. PMID: 19657021

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein. Endosome. Note=Interaction with SNX27 mediates recruitment to early endosomes, while interaction with SLC9A3R1 and EZR might target the protein to specialized subcellular regions, such as microvilli.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 数据库链接：

    KEGG: mmu:15562

    STRING: 10090.ENSMUSP00000027560

    UniGene: Mm.20440