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  4. Recombinant Human Receptor activity-modifying protein 1 (RAMP1)

Recombinant Human Receptor activity-modifying protein 1 (RAMP1)

  • 货号：
    CSB-CF019304HU
  • 规格：
  • 来源：
    in vitro E.coli expression system
  • 其他：

产品详情

  • 基因名：
  • Uniprot No.：
  • 别名：
    RAMP1; Receptor activity-modifying protein 1; Calcitonin-receptor-like receptor activity-modifying protein 1; CRLR activity-modifying protein 1
  • 种属：
    Homo sapiens (Human)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-148
  • 氨基酸序列
    CQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) to the plasma membrane. Acts as a receptor for calcitonin-gene-related peptide (CGRP) together with CALCRL.
  • 基因功能参考文献：
    1. T-A-T RAMP1 gene haplotype might have utility as a genetic marker for Essential Hypertension and that the RAMP1 gene may be associated with increased susceptibility to Essential Hypertension in a Japanese population. PMID: 28181496
    2. Evidence that DNA methylation at RAMP1 gene promoter plays a role in migraine was described. PMID: 26501962
    3. RAMP1 rs7590387 has a role in the transformation of episodic migraine into medication overuse headache. PMID: 25881990
    4. A novel functional role for RAMP1 in regulation of CaSR signalling in addition to its known role in receptor trafficking, is reported. PMID: 24454825
    5. multiple NKX3.1 binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate. PMID: 23867798
    6. RAMP1 overexpression enhances the promoting effect that exogenous CGRP has on osteogenic differentiation PMID: 22949393
    7. No significant association of the tested SNPs of the RAMP1 gene were found with migraine susceptibility. PMID: 23237777
    8. CLR and RAMP1 co-localize in the enteric nervous system of human stomach, ileum, and colon, and are in close proximity to their ligands CGRP and IMD PMID: 22484227
    9. The present finding demonstrated that RAMP1 immunoreactivity was localized in many neurons and phenopalatine ganglion. PMID: 22208649
    10. lower expression in bronchial biopsies from subjects with asthma PMID: 20933260
    11. The T-A-C haplotype is a genetic marker for cerebral infarction, and RAMP1 is associated with increased susceptibility to cerebral infarction. PMID: 19710695
    12. These data for the first time pinpoint a specific RAMP1 residue important for both antagonist and agonist potency and are consistent with the N-terminal domain of RAMP1 forming the binding pocket interface with calcitonin receptor-like receptor. PMID: 20188075
    13. RAMP1 overexpression attenuates Ang-II-induced hypertension and induces a protective change in cardiovascular autonomic regulation PMID: 20100989
    14. Co-expression of RAMP1 and CRLR reconstituted a CGRP receptor that was able to activate the pheromone-signaling pathway with pharmacological properties similar to those observed previously in mammalian cells. PMID: 11733510
    15. Receptor activity-modifying protein 1 determines the species selectivity of non-peptide CGRP receptor antagonists. PMID: 11847213
    16. The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function PMID: 12574158
    17. identification of domains responsible for agonist binding specificity PMID: 12684503
    18. TNF-alpha induced time- and dose-dependent decreases in the expression of RAMP1 mRNA in cultured human coronary artery smooth muscle cells, thereby diminishing AM-evoked cAMP production PMID: 15245870
    19. calcitonin receptor-like receptor heterodimer with RAMP1 yields a calcitonin gene-related peptide receptor PMID: 15613468
    20. RAMP1 interacts with tubulin. PMID: 17493758
    21. Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor and RAMP1. PMID: 17785463
    22. We did not observe any difference in mRNA for CL-R and RAMPs in arteries from patients with hemorrhagic stroke, arteriosclerosis and acute myocardial infarction when compared to patients without these diagnoses PMID: 18198792
    23. RAMP1 may be strongly considered as a candidate gene for migraine. PMID: 18240900
    24. Identification of RAMP1 residues important for calcitonin gene-related peptide are reported. PMID: 18593822
    25. the crystal structure of the extracellular domain of human RAMP1 at 2.4 A resolution was determined. PMID: 18725456

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    RAMP family
  • 组织特异性：
    Expressed in many tissues including the uterus, bladder, brain, pancreas and gastro-intestinal tract.
  • 数据库链接：

    HGNC: 9843

    OMIM: 605153

    KEGG: hsa:10267

    STRING: 9606.ENSP00000254661

    UniGene: Hs.471783