Recombinant Human D (1B) dopamine receptor (DRD5)

1. Dopamine D5 receptor may play an important role in the preservation of normal heart function by inhibiting the production of reactive oxygen species, via inhibition of NADPH oxidase, Nrf2 degradation, and ERK1/2/JNK pathways. PMID: 30153650
2. The C allele of DRD5 rs6283 SNP was associated with decreased risk of awake bruxism (p = 0.01). PMID: 28451935
3. DRD5 (dopamine receptor D5) agonists were potent inhibitors of pituitary tumor growth. PMID: 28613975
4. Meta-analysis of data from six sites of the International Multicentre persistent ADHD CollaboraTion tested the association of the common DRD5 alleles with categorically defined ADHD and with inattentive and hyperactive/impulsive symptom counts, found evidence that none of the common DRD5 alleles are associated with ADHD risk or ADHD symptom counts in adults. PMID: 27480019
5. Study investigated the contribution of DRD5 gene variants in the symptoms of attention-deficit/hyperactivity disorder (ADHD): 19 exonic variants were monomorphic in the Indo-Caucasoid individuals. rs6283 "C" and rs113828117 "A" exhibited significant higher occurrence in families with ADHD probands. Early and late onset groups exhibited significantly different genotypic frequencies. PMID: 27250208
6. This study reveled that DRD5 are up regulation in CD4+ T effector and regulatory cells in patient with multiple sclerosis. PMID: 27609280
7. DRD5 gene expression reduction in breast cancer patients after spiritual intervention PMID: 26597879
8. This study shown DRD5 to be the risk factor for attention deficit/hyperactivity disorder. PMID: 25840828
9. This study demonistrated that Lymphocyte DR D5 is reduced in MS and IFN-beta restores their expression and responsiveness. PMID: 25468276
10. Constitutive D5R signalling up-regulated expression of Na,K-ATPase-alpha2 and NHE-2, increasing glucose metabolism. Agonist treatment increased this and also upregulated NHE-3. PMID: 25154512
11. Our find-ings suggest that common genetic variations of DRD5 are likely to con-tribute to genetic susceptibility to paranoid schizophrenia in Han Chinese PMID: 24668635
12. confirmed at protein level the previously reported increased expression of DRD5 and the variably aberrant expression of ADORA2A, in Lesch-Nyhan disease lymphocytes PMID: 22403020
13. SNX1 has a crucial role in D(5)R trafficking and SNX1 depletion results in D(5)R dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension PMID: 23152498
14. Tests of a DRD5 microsatellite and four DRD5 single nucleotide polymorphism variants do not support a significant deviation from the Hardy-Weinberg equilibrium in either Caucasian or African American patients. PMID: 22203087
15. For the first time we report a significant association between nicotine dependence and DRD5, NPY1R MAP3K4 single nucleotide polymorphism. PMID: 22309839
16. intracellular loop 3 is the critical determinant underlying the subtype-specific regulation of human D5-dopaminergic receptor responsiveness by protein kinase C PMID: 21893192
17. Data show that the D5 receptor shows a trafficking profile distinct from that of any of the other dopamine receptors. PMID: 21348911
18. These findings suggest that the conflicting findings obtained in association studies between ADRA2A polymorphisms and ADHD might be related to temperament profiles, and support additional studies addressing these effects in larger samples. PMID: 20864182
19. The DRD5 expression in the temporal lobe of Alzheimer's disease patients is decressed. PMID: 20164562
20. susceptibility loci for attention deficit disorder with hyperactivity at DRD5 PMID: 12660802
21. these results suggest that there may be a functional variant of dopamine d5 receptor that conders susceptibility to developing focal dystonia in later life. PMID: 14509667
22. There is no association of DRD5 polymorphism with ADHD. PMID: 14755441
23. The ability of D5 receptor stimulation to decrease ROS production may explain, in part, the antihypertensive action of D5 receptor activation. PMID: 16352863
24. Preferential transmission of paternal alleles at risk genes for ADHD is established. PMID: 16380908
25. seven consecutive SNPs surrounding the D5 dopamine receptor gene (DRD5), were associated with the age at onset for attention deficit hyperactivity disorder PMID: 17501935
26. Genetic analyses of dopamine related genes in adult ADHD patients suggest an association with the DRD5-microsatellite repeat, but not with DRD4 or SLC6A3 VNTRs. PMID: 18081165
27. DRD5 (CA)(n) repeat has a modest effect in modulating susceptibility to adult attention deficit hyperactivity disorder PMID: 18164132
28. Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells PMID: 18464932
29. DRD5 protein is associated with ADHD. PMID: 18563476
30. co-localizes with dopamine D2 receptor (together, they activate a calcium signal); a robust calcium signal is also seen with dopamine D5 alone. PMID: 19171671
31. study reports the haplotype structure of the DRD5 coding region; analysis of the DRD5 coding region reveals two highly polymorphic SNPs in weak linkage disequilibrium and a low frequency of rare variants PMID: 19397556

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HGNC: 3026

OMIM: 126453

KEGG: hsa:1816

STRING: 9606.ENSP00000306129

UniGene: Hs.380681