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  4. HEK293/Human CLDN9-eGFP Stable Cell Line

HEK293/Human CLDN9-eGFP Stable Cell Line

  • 货号：
    CSB-SC005511HU
  • 规格：
    1 vial contains approximately 5x106 cells in 1 ml
  • 价格：
    ￥30000
  • 活性：
    • Untransfected HEK-293 cells (green line) and transfected Human CLDN9 HEK-293 stable cells (red line) were stained with anti-CLDN6/9 antibody(CSB-RA005508MA1HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.
    • Untransfected HEK-293 cells (green line) and transfected Human CLDN9 HEK-293 stable cells (red line) were stained with anti-CLDN6/9 antibody(CSB-RA005508MA3HU) (2µg/1*106cells), washed and then followed by APC-conjugated anti-Mouse IgG Fc antibody and analyzed with flow cytometry.
  • 其他：

产品详情

  • Uniprot No.：
    O95484
  • 生长类型：
    Adherent
  • 抗性：
    Puromycin
  • 培养基：
    DMEM + 10% FBS + 0.75 μg/mL Puromycin
  • 别名：
    CLDN9
  • 蛋白标签：
    C-terminal eGFP-tagged
  • 保存缓冲液：
    35% FBS + 55% DMEM + 10% DMSO
  • 应用范围：
    Binding assay by FACS and cell based ELISA.
  • 储存条件：
    Frozen in liquid nitrogen or -80°C
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

靶点详情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
  • 基因功能参考文献：
    1. CLDN9 may be an important biomarker for invasive pituitary oncocytomas. PMID: 25281028
    2. Claudins 6, 7, and 9 expressions are closely related to gastric carcinogenesis. PMID: 19960275
    3. Mouse studies suggest that claudin-9 deficiency may cause hearing loss not only in mice but also in humans. PMID: 19696885
    4. Residues N38 and V45 in the first extracellular loop (EL1) of CLDN9 are necessary for HCV entry. PMID: 17804490
    5. CLDN9, clustered with CLDN6 at human chromosome 16p13.3, is a four-transmembrane protein with WWCC motif, defined by W-X(17-22)-W-X(2)-C-X(8-10)-C. PMID: 12736707

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  • 亚细胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 组织特异性：
    Expressed in the liver, in peripheral blood mononuclear cells and hepatocarcinoma cell lines.
  • 数据库链接：

    HGNC: 2051

    OMIM: 615799

    KEGG: hsa:9080

    STRING: 9606.ENSP00000398017

    UniGene: Hs.296949