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  4. Recombinant Rat Tumor necrosis factor receptor superfamily member 11B (Tnfrsf11b)

Recombinant Rat Tumor necrosis factor receptor superfamily member 11B (Tnfrsf11b)

  • 货号：
    CSB-YP023969RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023969RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023969RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023969RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023969RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tnfrsf11b; Opg; Tumor necrosis factor receptor superfamily member 11B; Osteoprotegerin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-401
  • 氨基酸序列
    ETFPPKYLH YDPETGRQLL CDKCAPGTYL KQHCTVRRKT LCVPCPDYSY TDSWHTSDEC VYCSPVCKEL QTVKQECNRT HNRVCECEEG RYLELEFCLK HRSCPPGLGV LQAGTPERNT VCKRCPDGFF SGETSSKAPC RKHTNCSSLG LLLIQKGNAT HDNVCSGNRE ATQNCGIDVT LCEEAFFRFA VPTKIIPNWL SVLVDSLPGT KVNAESVERI KRRHSSQEQT FQLLKLWKHQ NRDQEMVKKI IQDIDLCESS VQRHIGHANL TTEQLRILME SLPGKKISPD EIERTRKTCK PSEQLLKLLS LWRIKNGDQD TLKGLMYALK HLKAYHFPKT VTHSLRKTIR FLHSFTMYRL YQKLFLEMIG NQVQSVKISC L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis.
  • 基因功能参考文献：
    1. Adipose-derived stem cell-released osteoprotegerin protects cardiomyocytes from reactive oxygen species-induced cell death. PMID: 28931423
    2. An upregulation of OPG was observed in the ovariectomized rats with streptozotocin-induced type 1 diabetes mellitus plus daily Zn supplementation group compared with the nonsupplemented and control groups. PMID: 28473060
    3. the canonical Wnt pathway inhibitor DKK1 blocked the osteogenesis effect and rescued the ratio of RANKL/OPG in periodontal ligament stem cells under force treatment for 1h. PMID: 27154288
    4. FGF21 inhibited VSMCs calcification via OPG/RANKL system, and through P38 andPI3K/AKT pathways. PMID: 28774557
    5. this study shows that flavonoids of Astragalus exert protective effects against adjuvant arthritis by regulating OPG/RANKL/NF-kappaB pathway PMID: 28092862
    6. In addition, curcumin upregulated the mRNA expression levels of transcription factors that favor osteoblast differentiation and increased the ratio of OPG to RANKL. PMID: 26677102
    7. The ratio of RANKL to OPG was very low during most of the arterial calcification period, which allowed for OPG to completely inhibit RANKL-induced osteoclast-like cell differentiation and to promote calcification. PMID: 26489619
    8. RANKL and OPG expressions were not changed by chronic exposure to fluoride in the drinking water during the studied periods; on the other hand, TRAP expression was changed (at 7 days) by chronic exposure to fluoride PMID: 22878484
    9. Lowering the serum homocysteine level by a simultaneous supplementation with N-acetylcysteine improved OPG and FOXO1 expression and partially antagonized RANKL and proresorptive cytokine synthesis in the bone milieu PMID: 23500899
    10. High-dose diosgenin treatment up-regulated expression of OPG significantly in tibia from OVX rats compared to control. PMID: 25257532
    11. Data indicate that the highest expression level of osteoprotegerin(OPG) was observed in jump (J) group. PMID: 25200151
    12. Cadmium could enhance receptor-activated nuclear factor kappa B ligand expression (RANKL) and inhibit osteoprotegerin (OPG) expression. PMID: 23954550
    13. RANKL and OPG expression promotes osteoclast development and enhances its function under the condition of estrogen deficiency PMID: 24321069
    14. Pulsed electromagnetic field can prevent ovariectomy-induced bone loss through regulating the expression of RANKL and OPG. PMID: 22948539
    15. Bisphosphonate in bone cement affects bone turnover by stimulating an increase in osteoprotegerin and a decrease in RANKL in the bone microenvironment. PMID: 23404413
    16. The concentration of sRANKL in gingival crevicular fluid increased significatly, then decreased sharply after orthodontic retention and bone remodeling. PMID: 22353912
    17. Epimedium extract can prevent glucocorticoid-induced femoral head necrosis probably by antagonizing glucocorticiod-induced abnormal expressions of OPG and RANKL mRNA. PMID: 22027774
    18. Ultrasound stimulation might be useful to protect against root resorption and accelerate its repair by regulating the expressions of OPG and RANKL. PMID: 21602131
    19. Ovariectomy caused a significant decrease in OPG gene expression in the tibia and aorta PMID: 21519319
    20. The temporospatial expression patterns of osteoprotegerin and RANKL suggest that osteoblasts and the lineage cell network orchestrates bone remodelling during distraction osteogenesis. PMID: 18476557
    21. except for the period of time in tooth eruption, where osteoclast formation is needed to form an eruption pathway, secretion of OPG (osteoprotegerin) prevents resorption of alveolar bone and subsequent disruption of the periodontal ligament PMID: 11839361
    22. reduces osteoclast numbers and prevents bone erosion in collagen-induced arthritis PMID: 12368214
    23. Detection of osteoprotegerin mRNA and protein in bone cells. PMID: 15704000
    24. Regulation of OPG production by the dental follicle likely affects the alveolar bone resorption needed for tooth eruption. PMID: 16283633
    25. RANK expression stimulates the activation and differentiation of osteoclast-like cells via low level laser irradiation in osteoclast precursor cells. PMID: 16568210
    26. Cytokine-induced production of OPG may protect beta cells from further damage, an effect mediated through inhibition of p38 map kinase phosphorylation. PMID: 17443309
    27. Results describe the effects of the administration of corticosterone, parathyroid hormone, or both, and of their withdrawal, on rat bone and cartilage histomorphometric parameters, and on osteoprotegerin and RANKL mRNA expression and proteins. PMID: 17476578
    28. Systemic delivery of osteoprotegerin inhibits alveolar bone resorption in experimental periodontitis, suggesting that RANKL inhibition may represent an important therapeutic strategy for the prevention of progressive alveolar bone loss. PMID: 17608585
    29. abnormal elevation of the OPG/tumor necrosis factor (ligand) superfamily member 10 ratio in the vessel wall characterizes the early onset of diabetes mellitus PMID: 17627577
    30. Data demonstrate that hyperprolactinemia can act directly on bone to stimulate bone turnover, and that prolactin enhances bone resorption in part by increasing RANKL and decreasing osteoprotegerin expression by osteoblasts. PMID: 18166509
    31. OPG/RANK/RANKL axis may be involved in cardiac remodeling in immuno-inflammatory myocardial diseases and progression of chronic HF and thus may represent targets for intervention in this disorder. PMID: 18417124
    32. Prolactin decreased osteoprotegerin mrna in cultured osteoblasts. PMID: 18432284
    33. demonstrate an imbalance of RANKL/OPG expression associated with diabetes that may contribute to the delay of fracture repair during the course of diabetes PMID: 18592139
    34. HLA-B27 transgenic rats show a reduced bone mass, and suggest an involvement of the RANKL/OPG system in the mechanism of bone loss in this disease PMID: 19040304
    35. OPG is a positive regulator of microvessel formation, while RANKL is an angiogenic inhibitor due to effects on regulation of endothelial cell proliferation, apoptosis, and signaling. PMID: 19105036
    36. low bone turnover after 1 yr of OPG overexpression in rats was associated with increased vertebral bone mass and proportional increases in bone strength, with no evidence for deleterious effects on vertebral material properties. PMID: 19257823
    37. Different values of traction force cause a variation of the RANKL/OPG ratio through the expression of RANKL protein, modulating the activities of bone remodeling in the subchondral bone of condyle. PMID: 19537860
    38. Orchiectomized rats exhibited increased RANKL protein in bone marrow plasma and in bone marrow cells, with no changes in serum RANKL. PMID: 19539794

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  • 亚细胞定位：
    Secreted.
  • 数据库链接：

    KEGG: rno:25341

    STRING: 10116.ENSRNOP00000011344

    UniGene: Rn.202973