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  4. Recombinant Rat TGF-beta receptor type-1 (Tgfbr1), partial

Recombinant Rat TGF-beta receptor type-1 (Tgfbr1), partial

  • 货号：
    CSB-YP023451RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP023451RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP023451RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP023451RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP023451RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tgfbr1; TGF-beta receptor type-1; TGFR-1; EC 2.7.11.30; Serine/threonine-protein kinase receptor R4; SKR4; TGF-beta type I receptor; Transforming growth factor-beta receptor type I; TGF-beta receptor type I; TbetaR-I
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Partial
  • 表达区域：
    30-124
  • 氨基酸序列
    LQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVEL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation.
  • 基因功能参考文献：
    1. a novel role for SREBP-1 as a cell surface retention factor for TbetaRI in mesangial cells, is reported. PMID: 27826032
    2. This study demonstrated that Transcutaneous auricular vagus nerve stimulation regulates expression of growth differentiation factor 11 and activin-like kinase 5 in cerebral ischemia/reperfusion rats. PMID: 27653860
    3. miR-22 acts as a novel negative regulator of angiotensin II-induced cardiac fibrosis by suppressing the expression of TGFbetaRI in the heart. PMID: 27997889
    4. The expressions of TGF-beta 1, TbetaRI, and TbetaRII in LPD and LPD + KA groups were significantly lower than those in NPD group and lower in LPD + KA group than those in LPD group PMID: 26788514
    5. Renal fibrosis resulting from excessive accumulation of extracellular matrix mainly driven by TGF-beta1 is dependent on the regulation of transforming growth factor receptor 1 expression by let-7b. PMID: 24088962
    6. cocaine self-administration resulted in an increase in TGF-beta R1 protein expression PMID: 24386286
    7. Despite long-term obstruction injury, inhibition of TGF-betaRII and ALK5 core fucosylation ameliorated the progression of renal fibrosis, an effect independent of TGF-betaRII and ALK5 expression. PMID: 23486519
    8. inhibiting ALK5 signaling in vitro antagonized the TGFbeta1-induced increase in astrocyte generation and antagonizing ALK5 signaling in vivo similarly inhibited astrogliogenesis within the SVZ during recovery from hypoxia-ischemia injury PMID: 20221422
    9. These findings suggest that TGF-beta signaling via ALK5 plays a critical role in maintaining heart valve integrity. PMID: 21859884
    10. TGF-beta1 caused apoptosis of pulmonary microvascular endothelial cell, an effect that was also dependent on ALK5 activity. PMID: 19270180
    11. These results suggest that AT1 inhibition in the developing kidney impairs renal growth and development and modulates the expression of ALK-5 and TbetaRII. PMID: 16897002
    12. Differential expression of TGF-beta type I and II receptors by pulmonary cells in bleomycin-induced lung injury correlate with repair and fibrosis, with reduced Tgfbr1 expression occurring during the early (days 4-7) stage of increased cell proliferation. PMID: 11936776
    13. results reveal that estrogen may directly modulate expression of transforming growth factor receptor type I mRNA in the hypothalamus PMID: 12097811
    14. Tgfbr1 had a marked yet transient upregulation in glomerular cells in experimental glomerulonephritis. PMID: 12545247
    15. TGF-beta type I receptor expression is suppressed by differentiated osteoblasts , when exposed to TGF-beta. PMID: 16806744
    16. Renal expression of mRNA is lower after tacroimus than in cyclosporine administration. PMID: 16980036
    17. Transforming growth factor beta receptor 1 were obviously expressed in primitive pulmonary alveolus, showing it plays an important regulatory role in the development of rat embryo and embryonic lung, especially in organic morphodifferentiation. PMID: 17428384
    18. These results indicate that high plasma cholesterol levels may contribute to the pathogenesis of certain diseases (e.g., atherosclerosis) by suppressing TGF-beta responsiveness. PMID: 17972267
    19. Early MMP-9 activation precedes the increase of TGF-beta signaling, and overt vascular elastocalcinosis and stiffness. PMID: 18292396
    20. The roles played by the ecto/transmembrane (ecto/TM) domains and endodomains of RI and RII TGF-beta receptors in these processes by transfecting 293 or HeLa cells with different combinations of receptor mutants, was analysed. PMID: 18598696
    21. Inhibition of TGF-beta signaling via activin receptor-like kinase-5 prevents development and progression of pulmonary hypertension in the monocrotaline model and may involve inhibition of pulmonary artery smooth muscle cell migration PMID: 19153267

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Membrane raft. Cell surface.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, TGFB receptor subfamily
  • 组织特异性：
    Urogenital ridge, testis, ovary, brain and lungs.
  • 数据库链接：

    STRING: 10116.ENSRNOP00000009452

    UniGene: Rn.44402