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  4. Recombinant Rat Protein C-ets-1 (Ets1)

Recombinant Rat Protein C-ets-1 (Ets1)

  • 货号：
    CSB-YP007852RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007852RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007852RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007852RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007852RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ets1; Ets-1Protein C-ets-1; p54
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-441
  • 氨基酸序列
    MKAAVDLKPT LTIIKTEKVD LELFPSPDME CADVPLLTPS SKEMMSQALK ATFSGFTKEQ QRLGIPKDPR QWTETHVRDW VMWAVNEFSL KGVDFQKFCM NGAALCALGK ECFLELAPDF VGDILWEHLE ILQKEDVKPY QVNGVNPTYP ESRYTSDYFI SYGIEHAQCV PPSEFSEPSF ITESYQTLHP ISSEELLSLK YENDYPSVIL RDPLQTDTLQ TDYFAIKQEV LTPDNMCMGR ASRGKLGGQD SFESIESYDS CDRLTQSWSS QSSFNSLQRV PSYDSFDSED YPAALPNHKP KGTFKDYVRD RADLNKDKPV IPAAALAGYT GSGPIQLWQF LLELLTDKSC QSFISWTGDG WEFKLSDPDE VARRWGKRKN KPKMNYEKLS RGLRYYYDKN IIHKTAGKRY VYRFVCDLQS LLGYTPEELH AMLDVKPDAD E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion.
  • 基因功能参考文献：
    1. Transcriptomic analysis of neuregulin-1 regulated genes following ischemic stroke by computational identification of promoter binding sites: A role for the ETS-1 transcription factor. PMID: 29856744
    2. data indicate a role for ETS-1 in the control of the GAL2R gene expression. PMID: 27349435
    3. Reduced renal expression of ETS-1 prevented hypertension-associated kidney injury in SS rats PMID: 28696249
    4. miR-125a-5p directly targets ETS-1, a transcription factor implicated in cell proliferation and migration and is crucial in PDGF-BB pathway in vascular smooth muscle cells. PMID: 28502794
    5. Knockdown of Ets-1 by siRNA significantly inhibited the inductive effects of Ang II on cell proliferation and expression of CTGF and PAI-1 PMID: 26617730
    6. Knockdown of miR-208b-3p expression attenuated apoptosis, while knockdown of Ets1 promoted apoptosis in myocardial ischemia reperfused rats. PMID: 26658785
    7. that salt-sensitive hypertension results in increased glomerular expression of phosphorylated ETS-1 and suggested that ETS-1 plays an important role in the pathogenesis of end-organ injury in salt-sensitive hypertension. PMID: 25624342
    8. ETS-1 overexpression induces beta-cell dysfunction partly through up-regulation of COX-2 gene expression. PMID: 24287791
    9. These data indicate that Ets-1 may influence neuronal injury following ischemia. PMID: 23246490
    10. Decreased expression of Ets-1 and increased expression of TIMP-2 may play an important role in the development of glomerulosclerosis and tubulointerstitial fibrosis in diabetic nephropathy PMID: 20598359
    11. Ets-1 plays a critical role in the regulation of endogenous prolactin gene expression and prolactin protein production. PMID: 12668863
    12. Ets-1 has a role in regulation of p21WAF1/Cip1 PMID: 12740370
    13. The colocalization of Ets-1 and HIF-1alpha in hypoxic areas suggests that hypoxia may induce Ets-1 and HIF-1alpha expression during joint inflammation PMID: 14730627
    14. PDGF-BB and Ets-1 may contribute to smooth muscle cell phenotypic switching associated with vascular injury. PMID: 14751865
    15. A temporal increase of mesangial cell Ets-1 expression correlates with mesangial cell activation in mesangioproliferative glomerulonephritis PMID: 15253715
    16. The Ets-1 pathway may regulate the transcription of cyclin D1 and control the regeneration of renal tubules in acute renal failure PMID: 15579511
    17. The Ets-1 transcriptional factor may participate in IL-1beta-mediated MMP-9 expression in tubulointerstitial cells. PMID: 16046515
    18. Sp1, like Ets-1, induces PDGF-D transcription and mRNA expression; H2O2 stimulates Ets-1, but not Sp1, and activates D3-dependent PDGF-D transcription PMID: 16189269
    19. Ets-1 promotes degradation of extracellular matrix proteins and is critical for integral kidney glomerular reorganization PMID: 16738537
    20. Ets family members Ets-1 and Elk-1 can positively regulate COX-2 promoter activity. PMID: 17505916
    21. VEGF, Ets-1, and ERK1 act synergistically in the development of diabetic retinopathy. PMID: 17622743
    22. Despite lacking an obvious motif for a canonical D-site sequence, recognized by ERK2 and used to promote catalysis, transcription factor Ets-1 is efficiently phosphorylated by ERK2 and is shown to interact with it. PMID: 17658891
    23. diabetes may contribute to increased cell proliferation due to N-ras constitutive activation, as well as to enhanced invasion and metastatic potential by increasing ets-1 levels PMID: 17708355
    24. Ets-1 may participate and play an important role in the regulation of follicular development, corpus luteum formation, maintenance, and regression in estrus and pregnancy in rats. PMID: 18439600
    25. Shear stress-induced Ets-1 modulates protease inhibitor expression in microvascular endothelial cells. PMID: 18636553
    26. Ets transcription factors play important roles for basic properties of rat C6 glioma cells, and targeting of these factors may become a useful tool for therapeutic strategies against malignant gliomas. PMID: 19148472

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    ETS family
  • 数据库链接：

    KEGG: rno:24356

    STRING: 10116.ENSRNOP00000062912

    UniGene: Rn.88756