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  4. Recombinant Rat Neuroglobin (Ngb)

Recombinant Rat Neuroglobin (Ngb)

  • 货号：
    CSB-YP015776RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP015776RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP015776RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP015776RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP015776RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ngb
  • Uniprot No.：
  • 别名：
    Ngb; Neuroglobin
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-151
  • 氨基酸序列
    MERPESELIR QSWRAVSRSP LEHGTVLFSR LFALEPSLLP LFQYNGRQFS SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA TLGRKHRAVG VRLSSFSTVG ESLLYMLEKC LGPDFTPATR TAWSQLYGAV VQAMSRGWDG E
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

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靶点详情

  • 功能：
    Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes.
  • 基因功能参考文献：
    1. Cerebral hemorrhage significantly inhibited the spatial learning and memory ability of rats; the mechanism may be related to decreased cerebral expression of BDNF and NGB PMID: 28829495
    2. In conclusion, this study shows that EPOR and Ngb were upregulated, and both of them act as important coordinated neuroprotectors in rh-EPO treatment of PWMD. However, the two proteins exhibit different expression patterns. PMID: 28359933
    3. Ngb expression is limited to the subpopulation of type I spiral ganglion cells, those which innervate inner hair cells, while the subpopulation of type II spiral ganglion cells which innervate the outer hair cells do not express Ngb. The cochlear nuclei and superior olivary complex (SOC) also express considerable amounts of Ngb. PMID: 25636685
    4. The present study first reported the yeast expressed production of Tat-NGB-His and His-NGB-His, and then elucidated the transduction and neuroprotection of Tat-NGB-His on PC12 cell PMID: 26646387
    5. Intermittent hypobaric hypoxia preconditioning activated the expression of neuroglobin and Bcl-2 in the rat hippocampal CA1 area following ischemia-reperfusion, and prevented hippocampal neuronal apoptosis. PMID: 26400308
    6. NEUROGLOBIN DISTRIBUTION IN THE RAT CEREBELLAR PURKINJE CELLS PMID: 26983282
    7. 1-Bromopropane(1-BP)resulted in decreased endogenous neuroprotectant neuroglobin in cerebral cortex, which might play an important role in central nervous system neurotoxicity induced by 1-BP. PMID: 25557405
    8. Study demonstrated that LED light exposure up-regulated NGB expression in rat retinas; alteration was induced predominantly by blue light compared to green or red light, and increased NGB levels were correlated with the severity of retinal light damage PMID: 24747803
    9. antioxidants in severe traumatic brain injury do not seem to support the role of neuroglobin as an endogenous neuroprotective antioxidant agent PMID: 24491879
    10. These findings indicated that Ngb might play an important neuro-protective effect after subarachnoid hemorrhage. PMID: 24281943
    11. It induces neuronal amyloid beta production. PMID: 23673310
    12. involved in pathogenesis of sepsis-associated encephalopathy and has neuroprotective effects PMID: 24145836
    13. High Neuroglobin levels are associated with reactive gliosis in response to eye injury. PMID: 23639750
    14. The results of this study suggested that Ngb could be involved in sleep regulation, independent of its role in the control of oxidative stress. PMID: 23262504
    15. Up-regulation of Ngb expression played an important role in the neuroprotection induced by limb ischemic preconditioning. PMID: 23180278
    16. Ngb mRNA expression in brain is associated with oxidative stress caused by arsenite exposure in rats. PMID: 22887765
    17. Neuroglobin could protect neurons from traumatic stress and secondary ischemia and hypoxia insults during ultra-early and acute stages of acute brain injury. PMID: 20476562
    18. NGB was upregulated in traumatic brain injury PMID: 22664218
    19. we showed that the NGB expression level in neurons increased continuously from 2 h after injury, and reached a peak at 16 h after which it decreased sharply PMID: 21915648
    20. We found that NGB was present in a rat astrocytoma cell line (C6), human astrocytoma cell line (U251), and human astrocytoma tissues PMID: 22009023
    21. Data support the hypothesis that an up-regulation of neuroglobin could be a compensatory mechanism in response to the hypoxic-ischemic insults caused by seizures in pups during intrauterine life. PMID: 21767627
    22. Ngb expression quickly increases when retinal ganglion cells die in acute retina ischemia, and expression is mainly intracytoplasmic. PMID: 21054965
    23. Cygb but not Ngb may protect cerebellar cells from the chronic presence of carbon monoxide exposure during prenatal and postnatal development. PMID: 20230802
    24. Neuroglobin expression was decreasd in the cochlea of rat pups exposed to chronic very mild carbon monoxide in air during and after the prenatal period. PMID: 20211612
    25. results indicate that the Ngb could be involved in both photic and nonphotic entrainment via input from the geniticulo-hypothalamic tract PMID: 20187147
    26. Up-regulation of neuroglobin expression in brain injury induced by LPS is correlated with duration after challenge of LPS. PMID: 19842562
    27. NGB mRNA and protein are abundantly expressed and widely distributed throughout the adult rat brain, as seen in the NGB-immunopositive signals of neuronal cell bodies and processes. PMID: 11820779
    28. acts as an endogenous neuroprotective factor in focal cerebral ischemia PMID: 12621155
    29. Examination of the cell type-specific expression of neuroglobin in neurons and astroglial cells in primary cultures of rat fetal hippocampal cells finds neuroglobin is only expressed in neurons. PMID: 15193759
    30. is present in the carotid body and increases after chronic intermittent hypoxia PMID: 16683692
    31. hypoxic stimulus presentation is a major determinant of the regulation of hypoxic sensitive genes such as Ngb PMID: 16750520
    32. it is unlikely that neuroglobin is instrumental in the acute response of neurons to hypoxic or ischemic insults PMID: 16796995
    33. Therefore, Ngb may act as an intracellular ROS scavenger, and such antioxidant properties may play a protective role against Abeta-induced cell injury. PMID: 17560688
    34. Recombinant neuroglobin is fused to human HIV-1 transactivator-of-transcription protein-transduction domain (TAT[49-57] PTD), enters primary cultured cortical neurons in a dose-dependent manner and protects the neurons from hypoxia-induced apoptosis. PMID: 17576199
    35. A diurnal variation of Ngb mRNA in the suprachiasmatic nucleus, having a peak in the day time (light-period) and nadir during night (dark-period). PMID: 18451642
    36. The cellular and physiological function of Ngb in different subsets of neurones might not be identical. PMID: 18509243
    37. Results demonstrate by immunohistochemical analysis the colocalization of neuroglobin and PrP(c) in the retinal ganglion cell layer. PMID: 19327369
    38. the role of Ngb during aging and hypoxia PMID: 19536481

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  • 亚细胞定位：
    Perikaryon.
  • 蛋白家族：
    Globin family
  • 组织特异性：
    Widely distributed throughout the adult brain, including cerebral cortex, hippocampus, thalamus, hypothalamus, olfactory bulb, and cerebellum.
  • 数据库链接：

    KEGG: rno:85382

    STRING: 10116.ENSRNOP00000016057

    UniGene: Rn.64645