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  4. Recombinant Rat Interleukin-15 (Il15)

Recombinant Rat Interleukin-15 (Il15)

  • 货号：
    CSB-YP011593RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011593RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011593RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011593RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011593RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Il15; Interleukin-15; IL-15
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    49-162
  • 氨基酸序列
    NW IDVRYDLEKI ESLIQFIHID TTLYTDSDFH PSCKVTAMNC FLLELQVILH EYSNMTLNET VRNVLYLANS TLSSNKNVIE SGCKECEELE ERNFTEFLQS FIHIVQMFIN TS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL15 requires interaction of IL15 with components of the IL2 receptor, including IL2RB and probably IL2RG but not IL2RA. In neutrophils, stimulates phagocytosis probably by signaling through the IL15 receptor, composed of the subunits IL15RA, IL2RB and IL2RG, which results in kinase SYK activation.
  • 基因功能参考文献：
    1. study indicates that training, skeletal muscle phenotype, and metabolic status all influence the temporal pattern of post-exercise changes in IL-15 expression. PMID: 25522723
    2. found that in diabetic rats, resistance training increased muscle and serum IL-15 levels PMID: 24006180
    3. results suggested that IL-15-Akt signaling harbored the complex signals for muscle-T cell interaction, the regulatory networks have significant potential for the restriction on IL-1beta inflammatory signaling PMID: 23017227
    4. IL-15 is related to organ dysfunction during severe acute pancreatitis, and it functions as a protective factor against the organ injuries. PMID: 20332642
    5. The results of this study suggest that the IL-15 signal transduction pathway in neural cells is similar to that in immune cells. PMID: 19747902
    6. IL-15 might antagonize some cytokine mediated cell death in islet cells. PMID: 12880684
    7. IL-15 produced by metastatic colon carcinoma cells can induce hyperplasia in the mucosa adjacent to colon cancer, thus contributing to angiogenesis and progression of the disease PMID: 14581351
    8. Cocultivation of lymphocytes with pancreatic stellate cells and IL-15 inhibited spontaneous lymphocyte apoptosis, and this effect was reduced by an anti-IL-15 antibody PMID: 16002563
    9. the decrease of CORT secretion by IL-15 is in part because of (i) the decrease of adenylate cyclase activity and cAMP production and (ii) the inhibition of 3beta-hydroxysteroid dehydrogenase and 11beta-hydroxylase activities in rat ZFR cells. PMID: 16405651
    10. Increases in IL-15 mRNA in response to atrophic stimuli may be an attempt to counteract muscle mass loss in skeletal muscles of old animals. PMID: 17135303
    11. IL-15 might have an inhibitory effect on the physiologic vascular remodeling processes in closing the ductus arteriosus. PMID: 17667861
    12. The changes observed in BAT suggest that IL-15 could be implicated in lipid consumption in this tissue by regulating lipid oxidation and probably thermogenesis, processes mediated by UCP1 and UCP3 and PPARdelta and PPARalpha. PMID: 18239634
    13. Preservation of IL-15 signaling by calorie restriction may therefore represent a further mechanism contributing to the anti-aging effect of this dietary intervention in skeletal muscle PMID: 19396981

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-15/IL-21 family
  • 数据库链接：

    KEGG: rno:25670

    UniGene: Rn.2490