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  4. Recombinant Rat Interleukin-1 receptor-associated kinase-like 2 (Irak2)

Recombinant Rat Interleukin-1 receptor-associated kinase-like 2 (Irak2)

  • 货号：
    CSB-YP689921RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP689921RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP689921RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP689921RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP689921RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Irak2Interleukin-1 receptor-associated kinase-like 2; IRAK-2
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-624
  • 氨基酸序列
    MACYIYQLPS WVLDDLCRNI DTLSEWDWMQ FASYVITDLT QLRKIKSMER VQGVSITREL LWWWSMRQAT VQQLVDLLCH LELYRAAQIV LSWKPAPDSL SPLSAFPEAV KPGPVATSGR NLKDDQKKGQ PVKPCSFLSS GTTMAGAQQQ ASCQRPCEED APCSLKTDVP DSLQSKYCST SIPKQEKLLN LPGDRLFWSE ADIVQATEDF DQSHRISEGT FADIYRGQRN GVAFAFKRLR EVTGSSPGSM DRFLQAEMQL CLRCCHPNIL PLLGFCTGRQ FHSLIYPYMA NGSLQDRLWA QGDSDMLSWP QRASICSGLL LAVEHLHSLD IIHSNVKSAN VLLDQHLNPK LAHPVAHPCP TNKKTKYTVM KTHLFQASAA YLPENFIRVG QLTKQVDIFS CGIVLAEVLT GIPAMDKDRS PVYLKDLLLS EIPSNTSSVH SRKTSMGKVV VKEICQKHLE RKAGLLPEAC AETWATAVSV CLRRREASLE EARVSMAGVE EQLRGQLSLP WSRVSEDTGS SSNTPEETDD VDNSSLSVPS SVMVVSCARV SSPPPSMGNG TAQPSTSGRQ EADSSSEACA GPQPPQEATE TSWKIEINEA KRRLMENILL YKEEKLDSVE LFGP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
  • 基因功能参考文献：
    1. Elevated circulating IL-1beta contributed to promote ER stress- induced myocytes apoptosis by affecting IRAK-2/CHOP pathway in diabetic cardiomyopathy. PMID: 26394923
    2. Expression of Irak2 increases ~ 15-fold at night in the rat pineal gland, as a result of adrenergic-cyclic AMP signalling. Night time levels are >15-fold greater than median expression levels in other tissues. PMID: 19103603
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, Pelle subfamily
  • 数据库链接：

    KEGG: rno:362418

    STRING: 10116.ENSRNOP00000034508

    UniGene: Rn.17123