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  4. Recombinant Rat Guanine nucleotide-binding protein subunit alpha-11 (Gna11)

Recombinant Rat Guanine nucleotide-binding protein subunit alpha-11 (Gna11)

  • 货号：
    CSB-YP872839RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP872839RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP872839RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP872839RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP872839RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gna11Guanine nucleotide-binding protein subunit alpha-11; G alpha-11; G-protein subunit alpha-11
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-359
  • 氨基酸序列
    MTLESMIACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAV VRAMDTLKIR YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE SKALFRTIIT YPWFQHSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs).
  • 基因功能参考文献：
    1. The secretory response to luminal propionate in rat colon is mediated by G-protein on cholesterol-rich membrane microdomains, provably via Galpha(q/11) . PMID: 21649864
    2. Levels of Galphaq, Galpha11, phospholipase C (PLC)-beta-1, and PLCbeta-2 proteins are significantly higher in vascular smooth muscle cells exposed to high glucose than in control cells, as determined by western blotting. PMID: 20393598
    3. data demonstrate that chronic ethanol feeding suppresses endothelin-1-stimulated glucose uptake and suggest that decreased expression of Galpha11 protein contributes to this response PMID: 12684223
    4. supersensitivity of the 5-HT2A receptors, during withdrawal from chronic cocaine, is associated with an increase in membrane-associated Galphaq and Galpha11 proteins PMID: 14534355
    5. There is striking specificity in Gq/11-coupled receptor actions on the Ca2+ channels. Differential use of PIP2 signals underlies specificity of Gq/11-coupled receptor actions on the channels. PMID: 15574748
    6. Immature frontal lobe Gq/11-coupled receptors elicit activation in a temporally coordinated manner with large calcium transients in most neurons in what appears to be a single explosive burst of activity that propagates as a wave over large distances. PMID: 15716410
    7. High glucose increases the expression of Gq/11alpha and PLC-beta proteins and associated signaling in vascular smooth muscle cells. PMID: 18820027

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor. Cytoplasm.
  • 蛋白家族：
    G-alpha family, G(q) subfamily
  • 数据库链接：

    KEGG: rno:81662

    STRING: 10116.ENSRNOP00000007498

    UniGene: Rn.21925