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  4. Recombinant Rat Fibulin-5 (Fbln5)

Recombinant Rat Fibulin-5 (Fbln5)

  • 货号：
    CSB-YP896264RA
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP896264RA
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP896264RA-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP896264RA
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP896264RA
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fbln5; DanceFibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance; Embryonic vascular EGF repeat-containing protein; EVEC
  • 种属：
    Rattus norvegicus (Rat)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-448
  • 氨基酸序列
    QQQCTNG FDLDRQTGQC LDIDECRTIP EACRGDMMCV NQNGGYLCIP RTNPVYRGPY SNPYSTSYSG PYPAAAPPVP ASNYPTISRP LVCRFGYQMD EGNQCVDVDE CATDSHQCNP TQICINTEGG YTCSCTDGYW LLEGQCLDID ECRYGYCQQL CANVPGSYSC TCNPGFTLND DGRSCQDVNE CETENPCVQT CVNTYGSFIC RCDPGYELEE DGIHCSDMDE CSFSEFLCQH ECVNQPGSYF CSCPPGYVLL EDNRSCQDIN ECEHRNHTCT PLQTCYNLQG GFKCIDPIVC EEPYLLIGDN RCMCPAENTG CRDQPFTILF RDMDVVSGRS VPADIFQMQA TTRYPGAYYI FQIKSGNEGR EFYMRQTGPI SATLVMTRPI KGPRDIQLDL EMITVNTVIN FRGSSVIRLR IYVSQYPF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.
  • 基因功能参考文献：
    1. upregulation of fibulin-5 is involved in the beneficial effect of RIPostC against cerebral I/R injury PMID: 28251683
    2. Fibulin-5 overexpression attenuated reactive oxygen species expression, which in turn decreased apoptosis and blood-brain barrier (BBB) permeability following middle cerebral artery occlusion and reperfusion. PMID: 26021746
    3. Fibulin-5 plays a role not only in the tissue repair and remodelling after renal tubular oxidative damage but also in renal cell carcinoma metastasis, presumably as a cytokine. PMID: 20942562
  • 亚细胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibulin family
  • 数据库链接：

    KEGG: rno:29158

    STRING: 10116.ENSRNOP00000007004

    UniGene: Rn.1699