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  4. Recombinant Pig Chromogranin-A (CHGA)

Recombinant Pig Chromogranin-A (CHGA)

  • 货号：
    CSB-YP005344PI
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005344PI
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005344PI-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005344PI
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005344PI
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    CHGAChromogranin-A; CgA) [Cleaved into: Pancreastatin; Parastatin; WE-14; Catestatin; GE-25; Serpinin-RRG; Serpinin; p-Glu serpinin precursor]; Fragment
  • 种属：
    Sus scrofa (Pig)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    17-446
  • 氨基酸序列
    LPVN SPMNKGDTEV MKCIVEVISD TLSKPSPMPV SQECFETLRG DERILSILRH QNLLKELQDL ALQGAKERSH QQKKQSSYED ELSEVLEKQN DQAELKEGTE EASSKEAAEK RGDSKEVEKN DEDADGAKPQ ASLEPPXXXE AEDQTPGEEE AASTHPLASL PSKKRPGAQA EEDHEGPSQG PVDREKGPSA EQGPQAEREE EEEAEAGEKA VPEEEGPRSE AFDSHPSLGY KEMQRGWPQA PAMDGAGKTG AEEAQPPEGK GAREHSRQEE EEETAGAPQG LFRGGKRGEP AQEEEERLSE EWENAKRWSK MDRLAKELTA EKRLQGEEEE EEEEEDPDRS MKLSFRAPAY GFRGPGLQLR RGWRPSSRED SVEAGLPLQV RXYLEEKKEE EGSANRRPED QELESLSAIE AELEKVAPQL QSLRRG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Strongly inhibits glucose induced insulin release from the pancreas.; Inhibits low calcium-stimulated parathyroid cell secretion.; Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist. Can induce mast cell migration, degranulation and production of cytokines and chemokines.; Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation.
  • 基因功能参考文献：
    1. High pancreastatin levels are significantly associated with neuroendocrine tumors. PMID: 24752611
    2. No circadian pattern was detected for salivary CgA in either spring or autumn, and there were no significant effects of gender or age. However, mean salivary CgA concentrations were significantly higher in the pigs sampled in autumn, compared to spring. PMID: 24507880
    3. expression and localization of chromogranin A (CgA), chromogranin B (CgB), synaptophysin, and insulin were ultrastructurally studied with the immunogold technique in porcine and human pancreatic islet neuroendocrine cells PMID: 12826904
  • 亚细胞定位：
    [Serpinin]: Secreted. Cytoplasmic vesicle, secretory vesicle.; Cytoplasmic vesicle, secretory vesicle. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle. Secreted.
  • 蛋白家族：
    Chromogranin/secretogranin protein family
  • 数据库链接：

    KEGG: ssc:397540

    STRING: 9823.ENSSSCP00000002657

    UniGene: Ssc.4653