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  4. Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn2a

Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn2a

  • 中文名称：
    Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn2a,Yeast
  • 货号：
    CSB-YP335466EUV
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn2a,Yeast
  • 货号：
    CSB-EP335466EUV
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn2a,Yeast
  • 货号：
    CSB-EP335466EUV-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn2a,Yeast
  • 货号：
    CSB-BP335466EUV
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Phoneutria nigriventer Delta-ctenitoxin-Pn2a,Yeast
  • 货号：
    CSB-MP335466EUV
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 别名：
    ; Delta-ctenitoxin-Pn2a; Delta-CNTX-Pn2a; Delta-CNTX-Pn1c; Neurotoxin Tx2-6; PnTx2-6
  • 种属：
    Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    35-82
  • 氨基酸序列
    ATCAGQ DQPCKETCDC CGERGECVCG GPCICRQGYF WIAWYKLANC KK
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Toxin that is known to potentiate erectile function. It binds voltage-dependently to sodium channels (Nav), inhibits the inactivation of the activated channels and decreases the peak inward current. The toxin delays inactivation of Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A and Nav1.8/SCN10A, slows the inactivation process and decreases the sodium peak amplitude of Nav1.5/SCN5A and Nav1.6/SCN8A. In vivo, it enhances erectile function by inducing the release of nictric oxide (NO): it slows the sodium current, leading to depolarization, which leads to an increase in calcium influx (probably via activation of N-type calcium channels) which in turn activates neuronal NO synthase (nNOS/NOS1), inducing nitric oxide (NO) production. In a final step, NO activates soluble guanylate cyclase (GUCY1A1/GUCY1B1) which in turn increases cGMP formation, resulting in penile erection. It is noteworthy that the toxin does not provoke erection by inhibiting phosphodiesterase type 5 (PDE5A), an enzyme that hydrolysis cGMP. In vivo, it also causes scratching, lacrimation, hypersalivation, sweating and agitation followed by spastic paralysis of the anterior and posterior extremities and death at dose levels of 0.79 mg/mouse. It is insecticidal to the larval and adult forms of the house fly. The toxin also improves cavernosal relaxation in different models where erectile dysfonction is observed, such as deoxycorticosterone-acetate (DOCA)-salt hypertensive rats, mice models for type-1 diabetes, as well as elderly rats.
  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Spider toxin Tx2 family
  • 组织特异性：
    Expressed by the venom gland.