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  4. Recombinant Mouse Zinc finger protein Helios (Ikzf2)

Recombinant Mouse Zinc finger protein Helios (Ikzf2)

In Stock
  • 货号：
    CSB-EP011576MO
  • 规格：
    ￥2328
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Ikzf2
  • Uniprot No.：
  • 别名：
    Ikzf2; Helios; Zfpn1a2; Znfn1a2; Zinc finger protein Helios; Ikaros family zinc finger protein 2
  • 种属：
    Mus musculus(Mouse)
  • 蛋白长度：
    Full Length
  • 来源：
    E.coli
  • 分子量：
    66.8 kDa
  • 表达区域：
    1-526aa
  • 氨基酸序列
    METDAIDGYITCDNELSPEGEHANMAIDLTSSTPNGQHASPSHMTSTNSVKLEMQSDEECDRQPLSREDEIRGHDEGSSLEEPLIESSEVADNRKVQDLQGEGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCSYACRRRDALTGHLRTHSVGKPHKCNYCGRSYKQRSSLEEHKERCHNYLQNVSMEAAGQVMSHHVPPMEDCKEQEPIMDNNISLVPFERPAVIEKLTANMGKRKSSTPQKFVGEKLMRFSYPDIHFDMNLTYEKEAELMQSHMMDQAINNAITYLGAEALHPLMQHAPSTIAEVAPVISSAYSQVYHPNRIERPISRETSDSHENNMDGPISLIRPKSRPQEREASPSNSCLDSTDSESSHDDRQSYQGNPALNPKRKQSPAYMKEDVKALDATKAPKGSLKDIYKVFNGEGEQIRAFKCEHCRVLFLDHVMYTIHMGCHGYRDPLECNICGYRSQDRYEFSSHIVRGEHTFH
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    3-7 business days
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Associates with Ikaros at centromeric heterochromatin.
  • 基因功能参考文献：
    1. These data provide a genetic basis for the unstable phenotype of Helios-deficient Tregs within the inflammatory environment of tumors and suggest that immune milieu-dependent alterations in gene expression are a central feature of Treg conversion. PMID: 29440380
    2. He is involved in the correct development of a subset of striatopallidal medium spiny neurons. PMID: 28289129
    3. Helios controls certain aspects of Treg-suppressive function, differentiation, and survival. PMID: 26582951
    4. this study reports that impaired expression of the transcription factor Helios by FoxP3+ CD4 and Qa-1-restricted CD8 Tregs results in defective regulatory activity and autoimmunity in mice. PMID: 26472910
    5. data suggest that a subset of DN T cells, identified by the expression of PD-1 and Helios, represent self-reactive cells; results provide an explanation for the origin of DN T cells and introduce CD8 loss as a process associated with self-Ag encounter PMID: 25825451
    6. results demonstrate that Helios is expressed by thymic and peripheral T cells that are being driven to tolerance in response to a genuine autoantigen PMID: 24740292
    7. identify Helios as the first marker known to diverge during positive and negative selection of thymocytes PMID: 23337809
    8. Helios regulates IL-2 production in Tregs by suppressing Il2 gene transcription. Loss of Helios in Tregs breaks their anergic phenotype and results in derepression of the Il2 locus. PMID: 23275607
    9. Helios expression spatially coincides with the early pattern of expression of the mature markers of striatal projection neurons. PMID: 22142223
    10. In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass. PMID: 22479644
    11. Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions. PMID: 21918685
    12. down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription factor in NK cells PMID: 22267813
    13. show that Helios is upregulated in CD4(+)CD25(+) regulatory T cells. PMID: 20226531
    14. silencing of Helios is critical for normal B cell function PMID: 16148093
    15. results demonstrate a vital function for Helios in maintaining normal homeostasis of developing T cells and formally show that non-DNA-binding isoforms of Helios are lymphomagenic if aberrantly expressed within the T-cell lineage PMID: 17110463
    16. Helios is not essential for T cells; its function can be compensated for by other members of the Ikaros family. PMID: 19620299

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Ikaros C2H2-type zinc-finger protein family
  • 组织特异性：
    Restricted to the T-cell lineage. Abundant in thymus, low expression in bone marrow and brain and no detectable expression in spleen, liver, kidney or muscle.
  • 数据库链接：

    KEGG: mmu:22779

    STRING: 10090.ENSMUSP00000027146

    UniGene: Mm.106343