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  4. Recombinant Mouse Tumor protein p53-inducible nuclear protein 1 (Trp53inp1)

Recombinant Mouse Tumor protein p53-inducible nuclear protein 1 (Trp53inp1)

  • 中文名称：
    小鼠Trp53inp1重组蛋白
  • 货号：
    CSB-YP868764MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Trp53inp1重组蛋白
  • 货号：
    CSB-EP868764MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Trp53inp1重组蛋白
  • 货号：
    CSB-EP868764MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Trp53inp1重组蛋白
  • 货号：
    CSB-BP868764MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Trp53inp1重组蛋白
  • 货号：
    CSB-MP868764MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Trp53inp1
  • Uniprot No.：
  • 别名：
    Trp53inp1; Sip; Tumor protein p53-inducible nuclear protein 1; Stress-induced protein; Thymus-expressed acidic protein; TEAP; p53-dependent damage-inducible nuclear protein 1; p53DINP1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-239
  • 氨基酸序列
    MFQRLNKMFV GEVTTSSSQE PEFSEKEDDE WILVDFIDTC PGFSAEEEEE DEDIGEESSA EHTSVFSCLP ASLECLTDTS DSCFLQFESC PMEESWFITP PPCFTAGGLT TIKVETSPME NLLIEHPSMS VYAVHNSCPG LSEASCGNDE YNSSGPRMEA QSEMGKHIHC CVAALAAQAT FLEQPKSFRP SQWIKGHSER QSLNRNGLRR QNLTRDCHTR QMKHSGWVVH QPCPRQYNY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.
  • 基因功能参考文献：
    1. Knockout of miR-155 in cardiac fibroblasts improves cardiac remodeling by targeting TP53INP1. PMID: 26589288
    2. These data provide evidence that the TP53INP1 gene prevents metabolic syndrome, through a mechanism involving prevention of oxidative stress by mitochondrial homeostasis regulation. PMID: 25828351
    3. Nanog enhances miR-17/92 cluster expression that in turn targets Trp53inp1, thus contributing to release neural stem cell self-renewal constraints. PMID: 24076654
    4. TP53INP1 loss of expression contributes to pancreatic cancer formation in a conditional KrasG12D mouse model. PMID: 23578383
    5. these data emphasize the role of TP53INP1 in protection against cell injury PMID: 21235351
    6. Data show that induction of the stress-induced proteins (SIPs) SIP18 and SIP27, in human- and mouse-derived cell lines, is absent from cells with deleted, mutated or inactive p53, suggesting that regulation of SIP gene expression is dependent on p53. PMID: 12067065
    7. Tumor protein 53-induced nuclear protein 1 is a potential target for the prevention of colorectal cancer in patients with inflammatory bowel disease[Tumor protein 53-induced nuclear protein 1] PMID: 17242209

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  • 亚细胞定位：
    Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome.; [Isoform 2]: Cytoplasm.
  • 组织特异性：
    Ubiquitously expressed with highest levels in the thymus.
  • 数据库链接：

    KEGG: mmu:60599

    STRING: 10090.ENSMUSP00000029865

    UniGene: Mm.393018