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  4. Recombinant Mouse Transcriptional regulator ERG (Erg)

Recombinant Mouse Transcriptional regulator ERG (Erg)

  • 货号：
    CSB-YP007781MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007781MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007781MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007781MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007781MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Erg; Erg-3Transcriptional regulator ERG
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-486
  • 氨基酸序列
    MIQTVPDPAA HIKEALSVVS EDQSLFECAY GTPHLAKTEM TASSSSDYGQ TSKMSPRVPQ QDWLSQAPAR VTIKMECNPS QVNGSRNSPD ECSVNKGGKM VGSPDTVGMS YGSYMEEKHV PPPNMTTNER RVIVPADPTL WSTDHVRQWL EWAVKEYGLL DVDVLLFQNI DGKELCKMTK DDFQRLTPSY NADILLSHLH YLRETPLPHL TSDDVDKALQ NSPRLMHARN TGGAAFIFPN TSVYPEATQR ITTRPDLPYE PPRRSAWTGH SHLTPQSKAA QPSPSAVPKT EDQRPQLDPY QILGPTSSRL ANPGSGQIQL WQFLLELLSD SSNSNCITWE GTNGEFKMTD PDEVARRWGE RKSKPNMNYD KLSRALRYYY DKNIMTKVHG KRYAYKFDFH GIAQALQPHP PESSLYKYPS DLPYMGSYHA HPQKMNFVSP HPPALPVTSS SFFASPNPYW NSPTGGIYPN TRLPASHMPS HLGTYY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
  • 基因功能参考文献：
    1. ERG balances TGFbeta signalling through the SMAD1 and SMAD3 pathways, protecting the endothelium from endothelial-to-mesenchymal transition and consequent liver fibrosis in mice via a SMAD3-dependent mechanism. PMID: 29026072
    2. Reduced Erg dosage impairs survival of hematopoietic stem and progenitor cells. PMID: 28436588
    3. loss of ERG and FLI1 might contribute to the pathogenesis of vascular lung complications through the induction of inflammation. PMID: 28248553
    4. Combined, these data suggest a possible pathway linking GDF5, ERG and downstream factors in the processes of chondrocyte differentiation during articular joint formation. PMID: 26542169
    5. Our study reveals that ERG has essential and cell autonomous roles in endothelial cell development and blood vessel maintenance. PMID: 26061019
    6. We show that the gene expression signature specifically attributable to trisomy of Erg in the murine model is strongly correlated with gene expression changes in human Down syndrome hematopoietic cells. PMID: 25973911
    7. Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. PMID: 26097038
    8. ERG plays a critical role in coordinating the balance between self-renewal and differentiation of HSCs. PMID: 26385962
    9. ERG activates the transcriptional program regulated by YAP1 of the Hippo signaling pathway and found that prostate-specific activation of either ERG or YAP1 in mice induces similar transcriptional changes and results in age-related prostate tumors. PMID: 26058078
    10. ERG and APLNR are essential for endothelial homeostasis in venules in the lung and that perturbation in ERG-APLNR signaling is crucial for the development of pulmonary veno-occlusive disease. PMID: 25062690
    11. Regulation of Erg by TGF-beta was confirmed in these cells. PMID: 25139621
    12. Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer. PMID: 24591637
    13. E-twenty-six (ETS) transcription factors Ets related gene (Erg) and Ets1 are the most common sites for transposon insertion in SB-induced JAK2V617F-positive erythroleukemias PMID: 23533276
    14. Erg is required for the maintenance of the core EnMT regulatory factors that include Snail1 and Snail2 by binding to their promoter and intronic regions PMID: 22932696
    15. in mice, Erg overexpression induces the development of not only lymphoid leukemia but also erythro-megakaryocytic leukemia PMID: 22936051
    16. Erg is a critical regulator of adult hematopoietic stem cells, essential for maintaining self-renewal at times of high HSC cycling. PMID: 21673349
    17. ERG is capable of promoting the development of leukemia and is crucial for its maintenance. PMID: 21321361
    18. from the fetal period, ERG acts as a direct upstream regulator of Gata2 and Runx1 gene activity PMID: 21245161
    19. the expression of the VE-statin/egfl7 gene in endothelial cells and the specific importance of ETS and GATA factors PMID: 20808444
    20. Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome. PMID: 20007548
    21. The ETS factor ERG appears to be a critical regulator of endothelial cell differentiation. PMID: 20030844
    22. ERG is part of molecular mechanisms leading chondrocytes into a permanent developmental path and become joint forming cells, and may do so by acting downstream of GDF-5. PMID: 17336282
    23. Erg is required for definitive hematopoiesis, adult hematopoietic stem cell function PMID: 18500345
    24. IGF1 is a common target gene of Ewing's sarcoma fusion proteins EWS-FLI-1, EWS-ERG and FUS-ERG in mesenchymal progenitor cells PMID: 18648544
    25. ETS2 and ERG promote megakaryopoiesis and synergize with alterations in GATA-1 to immortalize hematopoietic progenitor cells. PMID: 19168790
    26. ERG is a hematopoietic oncogene that may play a direct role in myeloid leukemia pathogenesis. PMID: 19487285
    27. Results provide direct evidence for selective cooperating events in ERG-induced prostate tumorigenesis and offer a rational basis for combined therapeutic interventions against multiple oncogenic pathways in prostate cancer. PMID: 19592505
    28. Fli-1 and Erg have roles in normal hematopoietic stem cell and megakaryocyte homeostasis PMID: 19666492

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    ETS family
  • 数据库链接：

    KEGG: mmu:13876

    STRING: 10090.ENSMUSP00000109477

    UniGene: Mm.164531