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  4. Recombinant Mouse Synembryn-B (Ric8b)

Recombinant Mouse Synembryn-B (Ric8b)

  • 货号：
    CSB-YP773932MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP773932MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP773932MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP773932MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP773932MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ric8b
  • Uniprot No.：
  • 别名：
    Ric8b; Synembryn-B; Protein Ric-8B
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-520
  • 氨基酸序列
    MDEERALYIV RAGEAGAIER VLRDYSDKHR ATFKFESADE DKRKKLCEGI FKVLVKEVPT TCQVSCLEVL RILSRDKKIL VPVTTKENMQ ILLRLAKLHE SDDSLEKVSE FPVIVESLKC LCNIVFNSQM AQQLSLELNL AAKLCNLLRK CKDRKFINDI KCFDLRLLFV LSLLHTDIRS QLRYELQGLP LLTQILESAF SIKWTDEYES AIDHNGPPLS PQETDCAIEA LKALFNVTVD SWKVHKESDS HQFRVMAAVL RHCLLIVGPT EDKTEELHSN AVNLLSNVPV SCLDVLICPL THEETAQEAA TLDELPSDKT TEKDTALKNS TMVYNGMNME AIHVLLNFME KRIDKGSSYR EGLTPVLSLL TECSRAHRNI RKFLKDQVLP PLRDVTNRPE VGSTVRNKLV RLMTHVDLGV KQIAAEFLFV LCKERVDSLL KYTGYGNAAG LLAARGLLAG GRGDNWYSED EDTDTEEYKN AKPKEELLKP MGLKPDGTIT PLEEALSQYS VIEETSSDTD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP. Able to potentiate G(olf)-alpha-dependent cAMP accumulation suggesting that it may be an important component for odorant signal transduction.
  • 基因功能参考文献：
    1. Olfactory-specific Ric-8b knock-out mice of mixed sex do not express the Galphaolf protein in the olfactory epithelium. The mature olfactory sensory neuron layer is reduced and cell death increased. These mice have an impaired sense of smell. Ric-8b is essential for olfactory function, and it may also be essential for Galphaolf-dependent functions in the brain. PMID: 29118104
    2. Results indicate that a functional N-terminus in C/EBPbeta-LAP* is required for interacting with SWI/SNF and for Ric-8B gene repression in osteoblasts. PMID: 24585571
    3. a new role of Ric-8B in the crosstalk of two distinct G protein signaling pathways, which are possibly involved in a part of mechanisms of chronic heart failure. PMID: 24134321
    4. Data show that the Ric-8B gene is negatively regulated during osteoblast differentiation by the transcription factor C/EBPbeta. PMID: 21606199
    5. Ric-8BFL-catalyzed nucleotide exchange probably proceeds in the forward direction to produce Galpha-GTP in cells. PMID: 21467038
    6. Ric-8B plays a critical and specific role in the control of G alpha(s) protein levels by modulating G alpha(s) ubiquitination and positively regulates G(s) signaling PMID: 20133939
    7. Results show that Ric-8B, a putative guanine nucleotide exchange factor for Galphaolf, promotes efficient heterologous expression of odorant receptors. PMID: 16754875
    8. Ric-8B interacts with two different olfactory G protein subunits and is implicated as an important protein in odorant signal transduction. PMID: 18462949

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  • 亚细胞定位：
    Cytoplasm, cell cortex.
  • 蛋白家族：
    Synembryn family
  • 组织特异性：
    Predominantly expressed in the mature olfactory sensory neurons and also in a few regions in the brain.
  • 数据库链接：

    KEGG: mmu:237422

    UniGene: Mm.18936