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  4. Recombinant Mouse Signal transducer CD24 (Cd24)

Recombinant Mouse Signal transducer CD24 (Cd24)

  • 货号：
    CSB-YP329506MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP329506MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP329506MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP329506MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP329506MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd24; Cd24a; Ly-52; Signal transducer CD24; Lymphocyte antigen 52; Ly-52; M1/69-J11D heat stable antigen; HSA; Nectadrin; R13-Ag; X62 heat stable antigen; CD antigen CD24
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Cytoplasmic domain
  • 表达区域：
    27-53
  • 氨基酸序列
    NQTS VAPFPGNQNI SASPNPSNAT TRG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May have a pivotal role in cell differentiation of different cell types. May have a specific role in early thymocyte development. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity.
  • 基因功能参考文献：
    1. CD24 and CD49f expressions of E14.5 mouse mammary anlagen cells define putative distribution of earlier embryonic mammary stem cell activities. PMID: 29620414
    2. CD24 has a role in determining the epithelial phenotype of pancreatic cancer PMID: 27203385
    3. While no obvious role was found for CD24 in the normal development and maintenance of the dopaminergic nigrostriatal system in mice, it may have a role in mediating the neuroprotective aspects of GDNF in this system. PMID: 28182766
    4. CD24 cell surface expression may serve as a valuable biomarker in order to identify mammary tumors that will positively respond to targeted IGF1R therapies. PMID: 27179633
    5. mice negative or positive for CD24 did not differ in terms of tumor initiation and burden in 3 mammary and prostate tumor models tested, except for Apc1572T/+ mice, in which lack of CD24 reduced the mammary tumor burden slightly but significantly. PMID: 26978528
    6. Loss of CD24 in Mice Leads to Metabolic Dysfunctions and a Reduction in White Adipocyte Tissue. PMID: 26536476
    7. CD24 controls breast cancer radiation response. Loss of CD24 expression leads to radiation resistance. PMID: 25641732
    8. Delayed wound-healing in the absence of HSA/CD24 suggests that CD24 plays an important role in this process PMID: 26440795
    9. Findings indicate that CD24(+) antigen cells play a role in tumor migration and metastasis and support Janus kinase 2 protein (JAK2) as a therapeutic target in ovarian cancer. PMID: 25969154
    10. CD24 is a conserved marker for tracking divergent states in both reprogramming and standard pluripotent culture. PMID: 26076835
    11. CD24 in non-immune cells might be crucialfor the guidance and recruitment of leukocytes. PMID: 24956310
    12. CD24 expression negatively regulates the NF-kappaB pathway following experimental traumatic brain injury. PMID: 23881416
    13. the deletion of CD24 in an HSP-driven model of autoimmunity led to the unexpected development of regulatory T cell and MDSC populations that augmented immune tolerance. PMID: 24808359
    14. CD24 is shown in vitro and in vivo as being an important oncogene in the gut, and one that plays a critical role in the initiation and progression of carcinogenesis. PMID: 24500912
    15. Siglec-G-CD24 axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD. PMID: 24695850
    16. CD24 was shown to regulate CD8(+) T cell activation through HMGB1-mediated engagement of T cell RAGE. PMID: 24631155
    17. CD24 has a role in urothelial tumorigenesis and metastasis in male mice and is androgen regulated in mice and humans PMID: 23012401
    18. CD24 is expressed in gastric parietal cells, where it modulates gastric responses to H. felis and gamma-radiation. CD24 also regulates susceptibility to apoptosis in the distal murine gastrointestinal tract. PMID: 22899822
    19. CD24-based sorting in wild-type mice isolates a colonic epithelial fraction highly enriched in actively cycling and quiescent Lgr5 positive putative colonic epithelial stem cells. PMID: 22723265
    20. Results suggest that LKB1 inactivation in the context of RAS activation facilitates metastasis by inducing an SFK-dependent expansion of a prometastatic, CD24(+) tumor subpopulation. PMID: 22698401
    21. CD24 expression on thymic antigen-presenting cells (mTECs, DCs) down-regulates autoantigen-mediated clonal deletion of autoreactive thymocytes. PMID: 22213356
    22. The isolation and characterization of a rare, primary, nonhematopoietic, CD24+ progenitor cell population from normal, untreated mouse liver, is described. PMID: 21361791
    23. Report sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells. PMID: 21183658
    24. CD24 is expressed in an NFAT5-dependent manner during the mitogenic expansion of mature T lymphocytes under hypertonic conditions and is required to sustain T cell expansion under osmostress. PMID: 21037089
    25. antigen CD24 is not a major regulator of mammary stem/progenitor cell function, but rather plays a role in governing branching morphogenesis. PMID: 20352469
    26. CD24 is expressed in the Sox9(EGFPlo) population and marks intestinal epithelial stem cells that form organoids in culture. PMID: 20185687
    27. mice with a targeted mutation of CD24 are resistant to induction of experimental autoimmune encephalomyelitis PMID: 19786366
    28. Dynamic changes in surface expression of the identified antigens CD15, CD24, and CD29 in combination can be exploited for the experimental separation of key neural cell populations. PMID: 19725119
    29. N-glycans of the mouse glycoprotein HSA and its human analogue CD24 from lymphoblastoma, neuroblastoma and astrocytoma cell lines as well as from mouse brain homogenate were analysed and compared to each other PMID: 12829373
    30. CD24 has a role in risk and progression of multiple sclerosis PMID: 14657362
    31. Mouse CD24 acts cell nonautonomously to regulate transit-amplifying cells proliferation and/or differentiation in adult SVZ. PMID: 15737737
    32. These results demonstrate a novel role for CD24 as a regulator of CXCR4 function that could be relevant for breast cancer growth and metastasis. PMID: 16390867
    33. CD24 is required for normal presynaptic maturation and function. PMID: 16606832
    34. These results and previous published data indicate that mCD24 contributes to the regulation of the production of differentiated cells by controlling the proliferation/differentiation balance between transit-amplifying and committed differentiated cells. PMID: 17522896
    35. CD24 is not essential for exosome formation or release but may be a convenient exosome marker. Our studies suggest that exosomal secretion from the embryonic kidney could play a biological role at the fetal-maternal interphase. PMID: 17700640
    36. elongation, collateralization, fasciculation and path finding of corticospinal axons in mice proceed normally in the absence of CD24. PMID: 18022325
    37. CD24a expression levels discriminate Langerhans cells from dermal dendritic cells in murine skin and lymph nodes PMID: 18185529
    38. CD44 but not CD24 may be involved in the breast cancer pathway and is a target for oncolytic virotherapy PMID: 18632604
    39. results reveal that the CD24-Siglec G pathway protects the host against a lethal response to pathological cell death and discriminates danger- versus pathogen-associated molecular patterns PMID: 19264983
    40. interaction of CD24 with the cell adhesion molecule L1 is mediated by O-linked glycans carrying alpha2,3-linked sialic acid PMID: 19284289
    41. CD24 expressed on T cells is essential for homeostatic proliferation in lymphopenic host. PMID: 15477346

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    CD24 family
  • 组织特异性：
    In lymphoid, myeloid, and erythroid cells.
  • 数据库链接：

    KEGG: mmu:12484

    STRING: 10090.ENSMUSP00000057983

    UniGene: Mm.29742