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  4. Recombinant Mouse Protein XRP2 (Rp2)

Recombinant Mouse Protein XRP2 (Rp2)

  • 货号：
    CSB-YP880619MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP880619MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP880619MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP880619MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP880619MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Rp2
  • Uniprot No.：
  • 别名：
    Rp2; Rp2h; Protein XRP2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-347
  • 氨基酸序列
    GCCFTKRRK SEKAEGEEEQ PKLYSWDQRE KVDPKDYMFS GLKDETVGRL PGKVAGQQFV IQDCENCNIY IFDHSATITI DDCTNCVIFL GPVKGSVFFR NCRDCKCTLA CQQFRVRDCR KLEVFLCCAT QPIIESSTNI KFGCFQWYYP ELAAQFKDAG LSIFNNIWSH VHDFTPVSGE LNWSLLPENA VVQDYVPIPM TEEFKAVRIS TEANRSIVPV SRGQRQKYSD ESCLVVLFAD DYTTANARKL IDEMVGKGFS LVQTKEMSMK TEDAQRVFQE KASDFLLLLN KGPVIALEFN GDDAVQECHL IVNGMFNGTK MFVSEKKETA SGDVDSFYNF AEIQMGI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
  • 基因功能参考文献：
    1. this study identifies ARL3 as a key player in prenylated protein trafficking in rod photoreceptor cells and establishes the potential role for ARL3 dysregulation in the pathogenesis of RP2-related forms of X-linked retinitis pigmentosa PMID: 26936825
    2. RP2 has a role in cone photoreceptor sensory cilium elongation in mice PMID: 26383048
    3. we first performed detailed characterization of the Rp2-knockout (Rp2-KO) mice and observed early-onset cone dysfunction PMID: 26358772
    4. Our studies suggest that RP2 contributes to the maintenance of photoreceptor function and that cone opsin mislocalization represents an early step in XLRP caused by RP2 mutations. PMID: 23745007
    5. We propose that RP2 regulation of Arl3 is important for maintaining Golgi cohesion, facilitating the transport and docking of vesicles and thereby carrying proteins to the base of the photoreceptor connecting cilium for transport to the outer segment. PMID: 20106869

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  • 亚细胞定位：
    Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, cilium.
  • 蛋白家族：
    TBCC family
  • 组织特异性：
    Retina (at protein level).
  • 数据库链接：

    KEGG: mmu:19889

    STRING: 10090.ENSMUSP00000033372

    UniGene: Mm.288141