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  4. Recombinant Mouse Pleckstrin homology-like domain family A member 1 (Phlda1)

Recombinant Mouse Pleckstrin homology-like domain family A member 1 (Phlda1)

  • 中文名称：
    小鼠Phlda1重组蛋白
  • 货号：
    CSB-YP737079MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Phlda1重组蛋白
  • 货号：
    CSB-EP737079MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Phlda1重组蛋白
  • 货号：
    CSB-EP737079MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Phlda1重组蛋白
  • 货号：
    CSB-BP737079MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Phlda1重组蛋白
  • 货号：
    CSB-MP737079MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Phlda1
  • Uniprot No.：
  • 别名：
    Phlda1; Tdag51; Pleckstrin homology-like domain family A member 1; Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; T-cell death-associated gene 51 protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-405
  • 氨基酸序列
    MRRTPAAERL SELGFPPRRG RQEPPFPLGV TRGWGGWPIE KRREGPRPVP FSERSPEDGR EQPAHGSGIL WRVRTRLSLC RDPEPPPPPP PLCLLRVSLL CALRAGGRGS RWGEDGAGLL LLPPAGASGS LKAERSSSTP YAGRMLENSG CKALKEGVLE KRSDGLLQLW KKKCCILTEE GLLLIPPKQL QQQQQQQQPG QGTAEPSQPS GPTVASLEPP VKLKELHFSN MKTVDCVERK GKYMYFTVVM TEGKEIDFRC PQDQGWNAEI TLQMVQYKNR QAILAVKSTR QKQQHLVQQQ PPQTQQIQPQ PQPQIQPQPQ PQIQPQPQPQ PQPQPQPQPQ PQPQQLHSYP HPHPHPYSHP HQHPHPHPHP HPHPHPHPYQ LQHAHQPLHS QPQGHRLLRS TSNSA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. Required for TCR-induced apoptosis and expression of TNFRSF6/FAS in a T-cell hybridoma cell line. May be involved in translational regulation.
  • 基因功能参考文献：
    1. The data presented herein demonstrate TDAG51 expression to be upregulated in damaged skeletal muscle and its absence attenuates the early phases of muscle regeneration. PMID: 29127005
    2. PHLDA1 plays a critical role in the development of progressive lung contusion and subsequent inflammation. PMID: 27960185
    3. These findings suggested that TDAG51 up-regulation is a dependent event during LPS-mediated proliferation and cell cycle progression, and which increase our understanding of the interaction mechanism between LPS and macrophages. PMID: 26873343
    4. The JAK2-ERK1/2-STAT3 pathway is an important signaling pathway for regulation of PHLDA1 expression. PMID: 26239656
    5. TDAG51 has a protective role in oxidative stress-induced cell death in mouse embryonic fibroblasts. PMID: 23928855
    6. Our results suggest that the balance between the cell survival and death signals mediated by HSP70 and TDAG51, respectively, may be disturbed by the altered expression of HSF1 during the progression of disease in this amyotropic lateral sclerosis model. PMID: 23063459
    7. TDAG51 is involved in energy homeostasis at least in part by regulating lipogenesis in liver and white adipose tissue. PMID: 22961087
    8. PHLDA1 expression marks the putative epithelial stem cells, downregulates ITGA2 and ITGA6, and contributes to intestinal tumorigenesis PMID: 21558389
    9. TDAG51 is induced by homocysteine, promotes detachment-mediated PCD, and contributes to the development of atherosclerosis observed in hyperhomocysteinemia PMID: 12738777

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  • 亚细胞定位：
    Cytoplasm. Cytoplasmic vesicle. Nucleus, nucleolus.
  • 组织特异性：
    Widely expressed with very high levels in adult liver and high levels in adult lung. According to PubMed:10428057 expressed at low levels in liver. Expressed at increased levels in atherosclerotic lesions observed in hyperhomocysteinema.
  • 数据库链接：

    KEGG: mmu:21664

    STRING: 10090.ENSMUSP00000132815

    UniGene: Mm.3117