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  4. Recombinant Mouse Peroxiredoxin-2 (Prdx2)

Recombinant Mouse Peroxiredoxin-2 (Prdx2)

  • 货号：
    CSB-YP730728MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP730728MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP730728MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP730728MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP730728MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Prdx2; Tdpx1; Tpx; Peroxiredoxin-2; EC 1.11.1.15; Thiol-specific antioxidant protein; TSA; Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    2-198
  • 氨基酸序列
    ASGNAQIGK SAPDFTATAV VDGAFKEIKL SDYRGKYVVL FFYPLDFTFV CPTEIIAFSD HAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTKS LSQNYGVLKN DEGIAYRGLF IIDAKGVLRQ ITVNDLPVGR SVDEALRLVQ AFQYTDEHGE VCPAGWKPGS DTIKPNVDDS KEYFSKHN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
  • 基因功能参考文献：
    1. Data suggests that Prdx1 and Prdx2 in pronuclei of zygotes are involved in antioxidant mechanisms and epigenetic programming during maternal-to-zygotic transition (during ectogenesis following in vitro fertilization). PRDX1 and PRDX2 appear to be ninth and twenty-second highest expressed proteins, respectively, among 64 proteins identified in mouse zygotes. PMID: 29503398
    2. our data highlight a novel role of Prx2 in iron homeostasis. Prx2 is a key cytoprotector against IO that is induced either by iron supplementation or due to chronic hemolysis as in beta-thalassemia. PMID: 28793778
    3. The data indicate that Prx2 is able to interrupt the hypoxia induced vicious cycle involving oxidation-inflammation-autophagy in the pathogenesis of pulmonary hypertension. PMID: 28801243
    4. one of the antioxidant enzymes, Prdx-2, was abundantly nitrosylated and temporarily reduced in antioxidant activity, causing transient endogenous hydrogen peroxide (H2O2) accumulation and subsequent X-box binding protein-1s/phosphatidylinositol 3-kinase pathway activation.Prdx-2 nitrosylation could be a potent strategy to affect the pluripotent stem cell-derived cardiomyogenesis. PMID: 27261193
    5. Oxidative stress promotes PRX2 and PRX3 hyperoxidation and attenuates pro-survival signaling in aging chondrocytes. PMID: 26797130
    6. The ventral signal observed for Prdx2 from early stages colocalized with motor neuron markers Isl1/2 and FoxP1 and strong ventral signal colocalizing with Isl1/2 was observed in all rostrocaudal segments of the spinal cord. PMID: 25975898
    7. Prx2 glutathionylation is a favorable reaction that can occur in cells under oxidative stress and may have a role in redox signaling. GSH/Grx1 provide an alternative mechanism to thioredoxin and thioredoxin reductase for Prx2 recycling. PMID: 26601956
    8. PrxII functions as a protective antioxidant enzyme against collagen-stimulated platelet activation and platelet-dependent thrombosis PMID: 25802339
    9. Prx I and Prx II appear to have a tight association with the mechanism underlying the protection of ESC stemness in developing teratomas. PMID: 24715692
    10. results suggest that inactivation of PrxII is important for the stability of FoxO1 protein, which subsequently mediates Foxp3( ) Treg cell development, thereby attenuating colonic inflammation PMID: 24048895
    11. PRDX2 neutralizes hydrogen peroxide generated in vivo under the transient hypoxic conditions experienced as erythrocytes pass through the microcirculation. PMID: 23215741
    12. PRX2 battles poly(ADP-ribose) polymerase 1- and p53-dependent prodeath pathways after ischemic injury PMID: 23429506
    13. These findings suggest that Prx II plays an important role in preventing hemolytic anemia from oxidative stress by binding to Hb as a decameric structure to stabilize it. PMID: 22960070
    14. These results strongly demonstrate that Prx II plays an essential role in maintaining normal erythropoiesis by protecting DNA damage. PMID: 22749995
    15. This study shows that both fructose and glucose-sweetened liquid consumption results in fatty liver, with both sweeteners showing similar peroxiredoxin-2 expression. PMID: 22254090
    16. Prx-2 is upregulated via the PI3K/NF-kappaB pathway and attenuates oxidative stress during muscle differentiation and regeneration. PMID: 21902453
    17. Peroxiredoxin 2 is an important modulator of angiotensin II-induced podocyte injury. PMID: 21814176
    18. Prdx2 is a specific peroxidase that inhibits atherogenic responses in vascular and inflammatory cells in ApoE deficient mice. PMID: 21835911
    19. The data of this study suggested that Prx II help maintain hippocampal synaptic plasticity against age-related oxidative damage. PMID: 19577336
    20. peroxiredoxin 2 may be involved in the modulation of maternal-fetal tolerance and that insufficient expression of this protein may correlate with increased embryo loss in CBA/J x DBA/2J mice PMID: 21328451
    21. increased expression of Prx2 correlates with the severity of the disease and that the amount of Prx2 bound to the membrane is markedly reduced in beta-thal mouse erythrocytes. PMID: 20488244
    22. peroxiredoxin-2, glutathione peroxidase-1, and catalase have roles in erythrocyte oxidative metabolism PMID: 19969073
    23. crystal of peroxiredoxin II obtained by the sitting-drop vapour-diffusion method diffracted to 1.77 A resolution at 100 K. PMID: 20208180
    24. Suggest that Prx II plays a key antioxidation role in the maturation of oocytes and development of early embryos. PMID: 19899112
    25. induced by oxidative and nitrosative stress in pancreatic beta cells PMID: 12107731
    26. results suggest that peroxiredoxin II plays a major role in protecting erythrocytes from oxidative stress in mice PMID: 12586629
    27. Prx II is recruited to PDGFR upon PDGF stimulation, and suppresses protein tyrosine phosphatase inactivation; Prx II also leads to the suppression of PDGFR activation in primary culture and a murine restenosis model PMID: 15902258
    28. These results suggest that peroxiredoxin II may function as an enzymatic antioxidant to prevent cellular senescence and skin aging. PMID: 16109412
    29. Prx II inhibits the immune cell responsiveness, which may be regulated by scavenging the low amount of reactive oxygen species (ROS). PMID: 16290204
    30. The results of this study provide direct evidence that the reduction of TR1 levels in malignant cells is antitumorigenic and suggest that the enzyme is a prime target for cancer therapy. PMID: 16565519
    31. cellular senescence in Prx II-/- MEF cells is mediated by ERK activation but not by NFkappaB activation PMID: 17050172
    32. reactive oxygen intermediates and subsequent oxidative stress generated from thioredoxin reductase are likely to contribute to paraquat-induced lung toxicity PMID: 17229725
    33. Essential negative regulator of lipopolysaccharide-induced inflammatory signaling through modulation of reactive oxygen species synthesis. PMID: 17325201
    34. Nitrosative stress leads to protein glutathiolation, increased s-nitrosation, and up-regulation of Prx VI, but not Prx II or Prx III in the heart PMID: 18426799
    35. findings suggest that B-cell activating factor (BAFF) and toll-like receptor 4 expressions are differentially regulated by peroxiredoxin II and TLR4 protein level may not be crucial in OVA-induced asthma PMID: 18442801
    36. in situ hybridization demonstrated that the sense and antisense transcripts were localized in almost the same limited areas of brain, testis, and spleen. It also revealed that the sense and antisense transcripts coexisted in Purkinje cells PMID: 18758163
    37. peroxiredoxin II may be a unique antioxidant in the cardiac system and may represent a potential target for cardiac protection from oxidative stress-induced injury. PMID: 19030911
    38. observed in the cytoplasm and residual bodies of spermatocytes and spermatids, after spermiation became confined to the mitochondrial sheath of the sperm tail midpiece PMID: 19208552

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    Peroxiredoxin family, AhpC/Prx1 subfamily
  • 组织特异性：
    Widely expressed with highest levels in bone marrow. High levels also found in heart, brain, kidney and skeletal muscle. Lower levels in liver, lung and thymus.
  • 数据库链接：

    KEGG: mmu:21672

    STRING: 10090.ENSMUSP00000005292

    UniGene: Mm.347009