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  4. Recombinant Mouse Nuclear autoantigen Sp-100 (Sp100)

Recombinant Mouse Nuclear autoantigen Sp-100 (Sp100)

  • 中文名称：
    小鼠Sp100重组蛋白
  • 货号：
    CSB-YP022439MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Sp100重组蛋白
  • 货号：
    CSB-EP022439MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Sp100重组蛋白
  • 货号：
    CSB-EP022439MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Sp100重组蛋白
  • 货号：
    CSB-BP022439MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Sp100重组蛋白
  • 货号：
    CSB-MP022439MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Sp100
  • Uniprot No.：
  • 别名：
    Sp100; Nuclear autoantigen Sp-100; Nuclear dot-associated Sp100 protein; Speckled 100 kDa
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-482
  • 氨基酸序列
    MEGSDGSPRM STEQENTEMH LIECMLKHFK TQKVAISNAI RSTFPFLESL RDHEFITGKM YEDLLDSCRS LVPVDKVIYR ALEELEKKFD MTVLCELFNE VNMEKYPDLN LIRRSFGCVF PNELCFQGID GGNPNSQLSL EQGPGASYSQ GSPNGSSLDL SASEGWRSND RRNSNLMQAN QTENHQLAES PGHLDSCELQ VQLNNRDATP ESCSLLPQNE ERAVQLNYEL QINPCFVQLV DVKKENSSFS LAGNQQTRAR TNQNEDSEII ELSSGDSDNG ENFSEATTTV PSQPAPAYSR KPPTLRRDRG GDTSDTESSI IIRRRKRTGR KKRERLGSYL IRNIKIPMKP SWKTAFLARS ANPSSQRRRK RGPRIPREEN ADFGGAELPV VCGNAQGFLD KEKFKQGIYV RSIRGKTGRL FTPMDFEIEG NCEKAKNWRQ SIRCKGWTLR ELIQKGVLQD PPRKKKETPR NPRQTRRQVN AL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation.
  • 基因功能参考文献：
    1. identification and analysis of the genes Sp100, Csprs, and Ifi75 in two members of the genus Mus, M. musculus and M. caroli PMID: 11471051
  • 亚细胞定位：
    Nucleus. Nucleus, PML body. Cytoplasm.
  • 数据库链接：

    KEGG: mmu:20684

    STRING: 10090.ENSMUSP00000066399

    UniGene: Mm.290906