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  4. Recombinant Mouse Netrin receptor UNC5A (Unc5a), partial

Recombinant Mouse Netrin receptor UNC5A (Unc5a), partial

  • 中文名称：
    小鼠Unc5a重组蛋白
  • 货号：
    CSB-YP818330MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Unc5a重组蛋白
  • 货号：
    CSB-EP818330MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Unc5a重组蛋白
  • 货号：
    CSB-EP818330MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Unc5a重组蛋白
  • 货号：
    CSB-BP818330MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Unc5a重组蛋白
  • 货号：
    CSB-MP818330MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Unc5a
  • Uniprot No.：
  • 别名：
    Unc5a; Kiaa1976; Unc5h1; Netrin receptor UNC5A; Protein unc-5 homolog 1; Protein unc-5 homolog A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.
  • 基因功能参考文献：
    1. Mannosylation by DPY19L1 but not DPY19L3 is required for transport of UNC5A from the endoplasmic reticulum to the cell surface. In vertebrates, a new C-mannosyltransferase has apparently evolved to increase glycosylation of TSRs, potentially to increase the stability of the structurally essential tryptophan ladder or to provide additional adhesion functions. PMID: 28202721
    2. UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis PMID: 20372800
    3. Findings suggest that DCC:UNC5H ratios in DA neurons at critical periods may have important consequences for the organization and function of mesocorticolimbic DA systems. PMID: 20628609
    4. Unc5h1 was cloned; its expression is restricted to the central nervous system in developing mouse PMID: 12351186
    5. a mechanism for UNC5H1-mediated apoptosis that requires an interaction with the MAGE protein NRAGE PMID: 12598531
    6. Results suggest that UNC5A promotes neuronal apoptosis during spinal cord development independent of netrin-1. PMID: 16829956

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Membrane raft. Cell projection, neuron projection.
  • 蛋白家族：
    Unc-5 family
  • 组织特异性：
    Restricted to central nervous system.
  • 数据库链接：

    KEGG: mmu:107448

    STRING: 10090.ENSMUSP00000026994

    UniGene: Mm.23573