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  4. Recombinant Mouse Methionine-R-sulfoxide reductase B1 (Msrb1)

Recombinant Mouse Methionine-R-sulfoxide reductase B1 (Msrb1)

  • 中文名称：
    小鼠Msrb1重组蛋白
  • 货号：
    CSB-YP864365MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Msrb1重组蛋白
  • 货号：
    CSB-EP864365MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Msrb1重组蛋白
  • 货号：
    CSB-EP864365MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Msrb1重组蛋白
  • 货号：
    CSB-BP864365MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Msrb1重组蛋白
  • 货号：
    CSB-MP864365MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Msrb1
  • Uniprot No.：
  • 别名：
    Msrb1; Sepr; Sepx1; Methionine-R-sulfoxide reductase B1; MsrB1; EC 1.8.4.12; EC 1.8.4.14; Selenoprotein R; SelR; Selenoprotein X; SelX
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-116
  • 氨基酸序列
    MSFCSFFGGE VFQNHFEPGV YVCAKCSYEL FSSHSKYAHS SPWPAFTETI HPDSVTKCPE KNRPEALKVS CGKCGNGLGH EFLNDGPKRG QSRFUIFSSS LKFVPKGKEA AASQGH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
  • 基因功能参考文献：
    1. Collectively, the results of this study suggest that selenoprotein MsrB1 plays a protective role against APAP-induced hepatotoxicity via its antioxidative function. PMID: 28986131
    2. MsrB1 deficiency does not increase high-fat diet-induced insulin resistance in mice. PMID: 27838938
    3. study identified the regulatory role of MsrB1 as a Mical antagonist in orchestrating actin dynamics and macrophage function PMID: 23911929
    4. MsrB1/Trx complex was studied in attempt to understand MsrB1 reduction mechanism. Using NMR data, molecular mechanics, protein docking & molecular dynamics simulations, found that intermediate MsrB1/Trx complex is stabilized by interprotein beta-layer. PMID: 22505815
    5. Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance. PMID: 21622567
    6. Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis. PMID: 20605785
    7. Study characterized unexpected diversity of protein and mRNA forms of mammalian selenoprotein MsrB1. PMID: 20634897
    8. MsrB1 recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress. PMID: 20584906
    9. Data show that methionine sulfoxide reductase (Msr)B1, but not MsrA, is the major methionine sulfoxide reductase in liver of mice and it is among the proteins that are most easily regulated by dietary selenium. PMID: 19769460
    10. The chemical shift index for MsrB1 indicates that the beta-sheets are the main element for the protein secondary structure. PMID: 19636847

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Cytoplasm, cytoskeleton.
  • 蛋白家族：
    MsrB Met sulfoxide reductase family
  • 数据库链接：

    KEGG: mmu:27361

    STRING: 10090.ENSMUSP00000099300

    UniGene: Mm.28212