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  4. Recombinant Mouse Interleukin-24 (Il24)

Recombinant Mouse Interleukin-24 (Il24)

  • 货号：
    CSB-YP821683MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP821683MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP821683MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP821683MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP821683MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Il24; Mda7Interleukin-24; IL-24; IL-4-induced secreted protein; Melanoma differentiation-associated gene 7 protein; MDA-7; Th2-specific cytokine FISP
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    27-181
  • 氨基酸序列
    QEFR SGSCQVTGVV LPELWEAFWT VKNTVQTQDD ITSIRLLKPQ VLRNVSGAES CYLAHSLLKF YLNTVFKNYH SKIAKFKVLR SFSTLANNFI VIMSQLQPSK DNSMLPISES AHQRFLLFRR AFKQLDTEVA LVKAFGEVDI LLTWMQKFYH L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.
  • 基因功能参考文献：
    1. our data suggest that IL-20 subfamily cytokines, particularly IL-20, IL-22, and IL-24, might provide therapeutic benefit for patients with Diabetic foot ulcers (DFU) . PMID: 28125663
    2. this study shows that IL-24 promotes Pseudomonas aeruginosa keratitis through the suppression of early protective mucosal immunity PMID: 28330899
    3. Loss of IL-24 expression is associated with breast cancer. PMID: 26460950
    4. A psoriasis-like skin inflammation in mice with epidermis-specific inhibition of NF-kappaB was triggered by TNFR1-dependent upregulation of interleukin-24 & activation of STAT3 signaling in keratinocytes. PMID: 24211183
    5. IL-24 suppresses the growth of normal vascular smooth muscle cells by inhibiting hydrogen peroxide-induced reactive oxygen species (ROS) production through the regulation of mitochondrial ROS production and expression of antioxidant enzymes PMID: 23052189
    6. Secretory mIL-24 did not induce the expression of the IL-6, TNF-alpha or IFN-gamma gene in spleen cells PMID: 22475191
    7. T cell receptor stimulation induces IL-24 expression in T helper type (Th)2 cells by the coordinate action of Stat6 and c-Jun transcription factors at the transcriptional level. PMID: 21357535
    8. induction of Il24 by oncogenes may support tumor growth at the early stages of cancer PMID: 15326486
    9. Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24 PMID: 18483274
    10. the novel splicing variant of IL24, FISP-sp dimerizes with FISP and blocks its secretion and inhibits FISP-induced apoptosis in vivo PMID: 18708357
    11. Data demonstrated that IL-24 predominately stimulated neutrophils to produce IFN-gamma and IL-12, subsequently activating CD8+ T cells both in vivo and in vitro. PMID: 19830736

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    IL-10 family
  • 组织特异性：
    Selectively expressed by Th2 cells.
  • 数据库链接：

    KEGG: mmu:93672

    STRING: 10090.ENSMUSP00000113064

    UniGene: Mm.196691