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  4. Recombinant Mouse Histone RNA hairpin-binding protein (Slbp)

Recombinant Mouse Histone RNA hairpin-binding protein (Slbp)

  • 货号：
    CSB-YP021372MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP021372MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP021372MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP021372MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP021372MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Slbp
  • Uniprot No.：
  • 别名：
    Slbp; Hbp; Histone RNA hairpin-binding protein; Histone stem-loop-binding protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-275
  • 氨基酸序列
    MACRPRSPPG YGSRRDGGAS PRSPARWSLG RKRRADGRDR KPEDSEEGEL QTADHRPESF TTPEGHKPRS RCSDWASAVE EDEMRTRVNK EIARYKRKLL INDFGRERKS SSGSSDSKES MSSVPADVET DESVLMRRQK QINYGKNTIA YDRYIKEVPR HLRQPGIHPR TPNKFKKYSR RSWDQQIKLW KVALHFWDPP AEEGCDLQEI QPVDLGEMET EFTESSSESQ TSSQDNFDVY AGTPTKVRHV DCQVEDEFDL EACLTEPLKD FSAMS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    RNA-binding protein involved in the histone pre-mRNA processing. Binds the stem-loop structure of replication-dependent histone pre-mRNAs and contributes to efficient 3'-end processing by stabilizing the complex between histone pre-mRNA and U7 small nuclear ribonucleoprotein (snRNP), via the histone downstream element (HDE). Plays an important role in targeting mature histone mRNA from the nucleus to the cytoplasm and to the translation machinery. Stabilizes mature histone mRNA and could be involved in cell-cycle regulation of histone gene expression. Involved in the mechanism by which growing oocytes accumulate histone proteins that support early embryogenesis. Binds to the 5' side of the stem-loop structure of histone pre-mRNAs.
  • 基因功能参考文献：
    1. During maturation, Slbp mRNA becomes polyadenylated and translationally activated. Proteasomal activity is required both to initiate and to sustain translational activation. PMID: 19759367
    2. SLBP expression and activity differ in mouse oocytes and early embryos compared with somatic cells. PMID: 12415002
    3. Inhibition of NF kappa B in TNF alpha-treated primary mouse hepatocytes is associated with increased S-phase cell cycle retention and decreased stem loop binding protein. PMID: 15179368
    4. histone synthesis in immature and maturing oocytes is governed by a translational control mechanism that is directly regulated by changes in the amount of SLBP PMID: 16125165
    5. SLBP is an essential component of the mechanism by which growing oocytes of the mouse accumulate the histones that support early embryonic development. PMID: 18036581
    6. Maternally encoded Slbp is degraded in 2-cell mouse embryos by the co-ordinated activity of two separately regulated pathways. PMID: 19298784

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    SLBP family
  • 组织特异性：
    Widely expressed. Expressed in growing primary but not non-growing oocytes, within the primordial follicles. Also detected in fully-grown oocytes in antral follicles (at protein level).
  • 数据库链接：

    KEGG: mmu:20492

    STRING: 10090.ENSMUSP00000062930

    UniGene: Mm.4172